The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges

Ndiaye, Mary A.; Philippe, Carol; Mukhtar, Hasan; Ahmad, Nihal

doi:10.1016/j.abb.2010.12.030

Cited by 174 publications

(131 citation statements)

References 105 publications

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“…Protective effects of RES on stressed keratinocytes could be associated with its antioxidant activity. Epidermis has a specific binding site for RES, thus topical application of RES is considered an effective approach in prevention and treatment of skin diseases (1). The results of this study demonstrate the ability of formulated ME to function as an efficient RES delivery system for transporting it into epidermal cells, and thus confirms the significant protective effect of RES against oxidative stress.…”

Section: Resultssupporting

confidence: 55%

Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress

2017

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Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stressResveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of formulated microemulsions by evaluating photoisomerization of resveratrol and to investigate the effects of resveratrol on human keratinocyte cells under oxidative stress caused by ultraviolet radiation. Incorporation of resveratrol into microemulsions resulted in increased photostability of active compounds and the results demonstrated that photodegradation of resveratrol was significantly delayed. Results of biopharmaceutical evaluation in vitro demonstrated that up to 60 % of resveratrol was released from microemulsions within 6 hours under a constant release rate profile. In vivo biological testing confirmed the ability of resveratrol to protect cells from oxidative stress and to increase cell viability. It was concluded that microemulsions might be considered in the development of UV light sensitive compounds.

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Section: Resultssupporting

confidence: 55%

Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress

2017

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“…Consequently, a number of products based on RSV have been developed for dietary and dermatological application 4,5 . Nevertheless, the efficiencies of RSV treatments and underlying mechanisms of action remained largely controversial.…”

Section: Introductionmentioning

confidence: 99%

Hormetic Shifting of Redox Environment by Pro-Oxidative Resveratrol Protects Cells Against Stress

Plauth

Geikowski

Cichon

et al. 2016

Preprint

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ABSTRACT:Resveratrol has gained tremendous interest owing to multiple reported healthbeneficial effects. However, the underlying key mechanism of action of resveratrol remained largely controversial. Here, we demonstrate that under physiologically relevant conditions major biological effects of resveratrol can be attributed to the generation of oxidation products such as reactive oxygen species (ROS). At low hormetic concentrations (< 50 µM), treatment with resveratrol increased cell viability in a set of representative cell models, whereas application of quenchers of ROS completely truncated these beneficial effects. Notably, application of resveratrol led to mild, Nrf2-specific cellular gene expression reprogramming. For example, in 2 primary human epidermal keratinocytes this resulted in a 1.3-fold increase of endogenous metabolites such as glutathione (GSH) and subsequently in a quantitative reduction of the cellular redox environment by 2.61 mV mmol GSH per g protein.After external application of oxidative stress by using 0.8% (v/v) ethanol, endogenous generation of ROS was consequently reduced by 24% in resveratrol pre-treated cells.In contrast to the common perception that resveratrol acts mainly as a chemical antioxidant or as a target protein-specific ligand, we propose that effects from resveratrol treatment are essentially based on oxidative triggering of cells. In relevant physiological microenvironments this effect can lead to hormetic shifting of cellular defence towards a more reductive state to improve resilience to oxidative stress in a manner that can be exactly defined by the redox-environment of the cell.

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“…Diphenylethene is a group of natural organic compounds with a C 6 -C 2 -C 6 unit in the parent nucleus, which have a variety of biological activities, such as anti-tumor, antihypertensive, ester, antiplatelet aggregation, antibacterial and so on. For example, resveratrol is a widely known natural product, which exhibited significant pharmacological activities [23][24][25][26] and considered a plant antitoxin. The structure of compound 5 can be regarded as the oxidized and cyclization of the vinyl group (C 2 ) in diphenylethene.…”

Section: Resultsmentioning

confidence: 99%

In vitro antitumor activity of chemical constituents of EtOAc extract from Artemisa gmelinii

Huang¹,

Wang²,

Pa³

et al. 2018

biomedicalresearch

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The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges

Cited by 174 publications

References 105 publications

Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress

Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress

Hormetic Shifting of Redox Environment by Pro-Oxidative Resveratrol Protects Cells Against Stress

In vitro antitumor activity of chemical constituents of EtOAc extract from Artemisa gmelinii

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