This research aimed to understand the US’s strategic interests, political goals, and geopolitical considerations in Afghanistan post-US military occupation, highlighting its strategic value for the US, given its connection to Central Asia, South Asia, China, and Russia, and its importance to US. This study used qualitative research to conduct a content analysis of the US’s strategic interests and geopolitical considerations in Afghanistan post-withdrawal, using the theories of realism offensive and defensive to determine the value of Afghanistan for the US in the region, thereby revealing US’s clear strategic interests. Afghanistan helped as a US strategic base, reducing China, India and Russia’s influence in the region, promoting its weapons industry, energy resource, indirect engagement and diplomatic initiatives, counter-terrorism, and non-proliferation and regional stability. The US also established a military presence and stable government in Afghanistan, focusing on US interests. Afghanistan has become a battleground for great powers like US, India, China, and Russia, who has used its strategic location for their own interests. The US has worked for its interests in Afghanistan for 20 years, and its policy changes and goals remain safe after withdrawal. However, their interests remain constant. The Afghan government and future generations must recognize Afghanistan’s significance for US strategic interests and geopolitical considerations. US’s priorities and policies change in the region, and when regional and great powers pose challenges, US’s presence in Afghanistan becomes possible.