The Groningen Cartilage Cutting Device: A New Instrument for Tympanoplasty

Meijer, Astrid G.W.; Westerlaken, Boris Olivier; Albers, F. W. J.

doi:10.1097/00005537-199912000-00025

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Numerous modifications of these basic principles have been described, including the use of combined cartilage‐perichondrium transplants. 4,10,14–18 …”

Section: Discussionmentioning

confidence: 95%

Acoustic Properties of Different Cartilage Reconstruction Techniques of the Tympanic Membrane

Mürbe¹,

Zahnert²,

Bornitz³

et al. 2002

The Laryngoscope

132

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“…Numerous modifications of these basic principles have been described, including the use of combined cartilage‐perichondrium transplants. 4,10,14–18 …”

Section: Discussionmentioning

confidence: 95%

Acoustic Properties of Different Cartilage Reconstruction Techniques of the Tympanic Membrane

Mürbe¹,

Zahnert²,

Bornitz³

et al. 2002

The Laryngoscope

132

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“…One of the most frequently used materials at the moment is hydroxylapatite. The biocompatible properties make hydroxylapatite particularly attractive for ossicular chain reconstruction, and also applications in other specialisms; for example, orthopedics [1][2][3][4][5][6][7][8][9][10][11][12]. Hydroxylapatite is a rigid dense calcium phosphate ceramic that conducts vibratory energy reasonably efficiently.…”

Section: Introductionmentioning

confidence: 99%

Histopathology of Biocompatible Hydroxylapatite-Polyethylene Composite in Ossiculoplasty

Meijer¹,

Segenhout²,

Albers³

et al. 2002

ORL

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The biocompatibility of hydroxylapatite-polyethylene composite implants (HAPEX, Smith and Nephew) was investigated in this study. Eleven middle ear prostheses, removed during revision surgery, have been examined by light microscopy, transmission electron microscopy and scanning electron microscopy. The results show that the middle ear prostheses become overgrown by fibrous tissue inside a thin epithelial layer. In some cases the prosthesis is covered by fibrous tissue without an outer layer of epithelial cells. No arguments have been found for the accumulation of macrophages and foreign body giant cells associated with a foreign body reaction to the material. Therefore, hydroxylapatite-polyethylene composite implants (HAPEX, Smith and Nephew) would seem to be very suitable for reconstructive middle ear surgery.

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“…The literature refers to average extrusion rates of biocompatible implants as varying from 15% to 22%; interposing a cartilage disk reduces extrusion rates to 3% to 6%, which are comparable to those of transplants. 1,[6][7][8][9][10][11][12] In this study, we implanted hydroxylapatite middle ear prostheses in the bullae of guinea pigs. The guinea pig temporal bone and its contents are similar to those of humans, but there are some minor differences.…”

Section: Introductionmentioning

confidence: 99%

Cartilage Interposition in Ossiculoplasty with Hydroxylapatite Prostheses: A Histopathologic Study in the Guinea Pig

Meijer

Verheul

Albers

et al. 2002

Ann Otol Rhinol Laryngol

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In this experimental animal study, a cartilage disk was interposed between a synthetic middle ear prosthesis and the tympanic membrane in guinea pigs to investigate its effect on the extrusion process of the implant. Two groups of guinea pigs were studied. One group consisted of animals in which the prosthesis was directly in contact with the tympanic membrane, and the other group consisted of animals in which a cartilage disk had been inserted between the head of the prosthesis and the tympanic membrane. Before histologic processing, in situ inspection was performed with an operating microscope. After fixation and embedding, light microscopic and transmission electron microscopic examination were performed. We studied the histopathologic aspects of the tympanic membrane with regard to the protrusion and extrusion processes of the middle ear implant. In this experimental model, protrusion and extrusion of a hydroxylapatite middle ear prosthesis was greatly reduced by interposition of a cartilage disk. Further clinical evaluation of these experimental results is needed in the human middle ear.

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The Groningen Cartilage Cutting Device: A New Instrument for Tympanoplasty

Cited by 4 publications

References 7 publications

Acoustic Properties of Different Cartilage Reconstruction Techniques of the Tympanic Membrane

Acoustic Properties of Different Cartilage Reconstruction Techniques of the Tympanic Membrane

Histopathology of Biocompatible Hydroxylapatite-Polyethylene Composite in Ossiculoplasty

Cartilage Interposition in Ossiculoplasty with Hydroxylapatite Prostheses: A Histopathologic Study in the Guinea Pig

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