The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the greek population

Tsezou, Aspasia; Satra, Maria; Oikonomou, Pagona; Bargiotas, K.; Malizos, Konstantinos N.

doi:10.1002/jor.20464

Cited by 43 publications

(41 citation statements)

References 26 publications

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“…Our data have shown that polymorphism exist in the GDf-5 (BsiE1) gene in North Indian population. The frequency of T allele in our population (55%) was similar to that reported in Caucasians (59-63 %) (Rouault et al, 2010;Southam et al, 2007;Tsezou et al, 2008;Valdes and Spector, 2009) the oriental population carry relatively higher frequency (70-74%) of variant T allele (Shin et al, 2012;Cao et al, 2010;Dai et al, 2008;Miyamoto et al, 2007).…”

Section: Discussionsupporting

confidence: 87%

“…Stratification of subjects on bases of sex further showed significant association of variant T allele with KOA in males and females. Similar association of variant T alleles with KOA in males and females has been demonstrated in Caucasians and Koreans (Cao et al, 2010;Tsezou et al, 2008;Southam et al, 2007).…”

Section: Discussionsupporting

confidence: 76%

“…Likewise Oriental (Japanese and Chinese) population also showed significant association of polymorphism in GDF-5 with knee OA (Miyamoto et al, 2007). However, inconsistent results have also been reported in those populations (Tsezou et al, 2008;Cao et al, 2010). This has been partly attributed to the smaller sample size and ethinic variations among them.…”

Section: Discussionmentioning

confidence: 96%

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Association of Polymorphism in Growth and Differentiation Factor 5 Gene With Osteoarthritis Knee

Mishra¹,

Sanghi²,

Sharma³

et al. 2013

American Journal of Biochemistry and Biotechnology

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The present study investigated to identify the association of polymorphism in GDF-5 gene with osteoarthritis in North Indian population. In a case-control study, 300 cases with knee osteoarthritis and an equal number of age and gender matched healthy controls were included. Cases were diagnosed using the ACR Guidelines of Knee Osteoarthritis (KOA). Clinical symptoms were assessed with the knee specific WOMAC index and VAS for knee pain. The severity of disease was determined by radiological KL grades (Kellgren Lawren). The variant genotype of GDF-5 was found to be present at significantly higher frequency in cases than in controls, resulting in about 1.79 fold increase in risk to OA. Genotype distributions of the GDF-5 also showed significant association of variant allele with clinical score of OA patients. An association between the+104T/C GDF5 polymorphism with knee OA and clinical symptom of OA in Indian population further demonstrate a strong genetic influence of this SNP in KOA.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Association of Polymorphism in Growth and Differentiation Factor 5 Gene With Osteoarthritis Knee

Mishra¹,

Sanghi²,

Sharma³

et al. 2013

American Journal of Biochemistry and Biotechnology

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“…Our results were consistent with the results of the study performed by Tsuzou et al (17), which conformed to the heterogeneous nature of OA genetic susceptibility. Tsuzou et al (17) indicated that there were no statistically significant differences in the genotype and allele frequencies of the +104T/C SNP of the GDF5 gene in patients and controls (p>0.05).…”

Section: Discussionsupporting

confidence: 94%

“…In addition, on categorizing the cases based on gender, no allele or genotype differences were found in the frequency distribution based on gender. Therefore, the results of the study performed by Tsezou et al (17) indicated that GDF5 (+104T/C) SNP is not a risk factor for KOA in Greek Caucasians. Similarly, our results were in accordance with the results of the study conducted by Southam et al (6), which revealed the absence of significant differences in genotype and allele frequency distribution of SNP in cases and healthy control subjects (p>0.05 and p=0.436, respectively).…”

Section: Discussionmentioning

confidence: 90%

Genetic influence of growth and differentiation factor 5 gene polymorphism (+104T/C) on the development of knee osteoarthritis and its association with disease severity

2017

Eur J Rheumatol

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Large‐scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

Εvangelou¹,

Chapman²,

Meulenbelt³

et al. 2009

Arthritis & Rheumatism

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188

148

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Objective GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of the GDF5 gene or the rs7775 and rs288326 polymorphisms of the FRZB gene have been conflicting or inconclusive. To examine these associations, we performed a large-scale meta-analysis of individual-level data. Methods Fourteen teams contributed data on polymorphisms and knee, hip, and hand OA. For rs143383, the total number of cases and controls, respectively, was 5,789 and 7,850 for hip OA, 5,085 and 8,135 for knee OA, and 4,040 and 4,792 for hand OA. For rs7775, the respective sample sizes were 4,352 and 10,843 for hip OA, 3,545 and 6,085 for knee OA, and 4,010 and 5,151 for hand OA, and for rs288326, they were 4,346 and 8,034 for hip OA, 3,595 and 6,106 for knee OA, and 3,982 and 5,152 for hand OA. For each individual study, sex-specific odds ratios (ORs) were calculated for each OA phenotype that had been investigated. The ORs for each phenotype were synthesized using both fixed-effects and random-effects models for allele-based effects, and also for haplotype effects for FRZB. Results A significant random-effects summary OR for knee OA was demonstrated for rs143383 (1.15 [95% confidence interval 1.09–1.22]) (P = 9.4 × 10−7), with no significant between-study heterogeneity. Estimates of effect sizes for hip and hand OA were similar, but a large between-study heterogeneity was observed, and statistical significance was borderline (for OA of the hip [P = 0.016]) or absent (for OA of the hand [P = 0.19]). Analyses for FRZB polymorphisms and haplotypes did not reveal any statistically significant signals, except for a borderline association of rs288326 with hip OA (P = 0.019). Conclusion Evidence of an association between the GDF5 rs143383 polymorphism and OA is substantially strong, but the genetic effects are consistent across different populations only for knee OA. Findings of this collaborative analysis do not support the notion that FRZB rs7775 or rs288326 has any sizable genetic effect on OA phenotypes.

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The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the greek population

Cited by 43 publications

References 26 publications

Association of Polymorphism in Growth and Differentiation Factor 5 Gene With Osteoarthritis Knee

Association of Polymorphism in Growth and Differentiation Factor 5 Gene With Osteoarthritis Knee

Genetic influence of growth and differentiation factor 5 gene polymorphism (+104T/C) on the development of knee osteoarthritis and its association with disease severity

Large‐scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

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