The growth hormone axis and cognition: empirical results and integrated theory derived from giant transgenic mice

Rollo, C. David; Ko, Chosho; Tyerman, JG A; Kajiura, Lovaye

doi:10.1139/z99-153

Cited by 17 publications

(6 citation statements)

References 247 publications

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“…Young TGM (<7 mo.) have vastly superior cognition than normal mice, learning an eight-choice radial maze in roughly half the trials required by age-matched normal mice (many of which did not learn at all) [Rollo et al, 1999;Lemon et al, 2003]. However, cognitive abilities of TGM rapidly deteriorated and by 11 months of age, most were unable to learn the maze.…”

Section: Introductionmentioning

confidence: 99%

A multi‐ingredient dietary supplement abolishes large‐scale brain cell loss, improves sensory function, and prevents neuronal atrophy in aging mice

Lemon

Aksenov

Samigullina

et al. 2016

Environ and Mol Mutagen

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Transgenic growth hormone mice (TGM) are a recognized model of accelerated aging with characteristics including chronic oxidative stress, reduced longevity, mitochondrial dysfunction, insulin resistance, muscle wasting, and elevated inflammatory processes. Growth hormone/IGF-1 activate the Target of Rapamycin known to promote aging. TGM particularly express severe cognitive decline. We previously reported that a multi-ingredient dietary supplement (MDS) designed to offset five mechanisms associated with aging extended longevity, ameliorated cognitive deterioration and significantly reduced age-related physical deterioration in both normal mice and TGM. Here we report that TGM lose more than 50% of cells in midbrain regions, including the cerebellum and olfactory bulb. This is comparable to severe Alzheimer's disease and likely explains their striking age-related cognitive impairment. We also demonstrate that the MDS completely abrogates this severe brain cell loss, reverses cognitive decline and augments sensory and motor function in aged mice. Additionally, histological examination of retinal structure revealed markers consistent with higher numbers of photoreceptor cells in aging and supplemented mice. We know of no other treatment with such efficacy, highlighting the potential for prevention or amelioration of human neuropathologies that are similarly associated with oxidative stress, inflammation and cellular dysfunction. Environ. Mol. Mutagen. 57:382-404, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

A multi‐ingredient dietary supplement abolishes large‐scale brain cell loss, improves sensory function, and prevents neuronal atrophy in aging mice

Lemon

Aksenov

Samigullina

et al. 2016

Environ and Mol Mutagen

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“…) and committed fewer errors in a radial maze task than normal mice (Rollo et al . ). Mondal et al .…”

Section: Discussionmentioning

confidence: 97%

“…Bovine GH transgenic mice were reported to have increased spontaneous activity (Rollo et al . ; Bohlooly et al . ) and committed fewer errors in a radial maze task than normal mice (Rollo et al .…”

Section: Discussionmentioning

confidence: 99%

Bovine growth hormone gene polymorphism affects stress response in Japanese Black cattle

Tachi

Tanaka

Ardiyanti

et al. 2014

Animal Science Journal

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We investigate the associations between growth hormone (GH) gene polymorphism and behavioral and physiological responses to stressors and learning ability in Japanese Black cattle. Flight distance test was conducted in the first experiment. Steers with haplotype C of GH gene polymorphism avoided human approaches at a significantly greater distance than ones without haplotype C (C: 1.9 ± 0.9, non-C: 1.0 ± 0.2 m, P < 0.05). An open-field test was conducted in the second experiment. Behavioral responses did not differ significantly between steers with and without haplotype C. Increases of heart rates to dropping of iron pipes was significantly higher in steers with haplotype C (C:161.7 ± 21.8, non-C:130.7 ± 31.3%, P < 0.05). Despite basal serum concentrations not being different between steers with and without haplotype C, serum cortisol in blood sampling immediately after severe confinement in a race tended to be higher in steers with haplotype C (P = 0.1). The maze test was conducted as the third experiment. There was no difference in performance in the maze test between steers with and without haplotype C. It is concluded that genetic polymorphism of GH may affect stress responses through GH concentration in steers.

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“…Although the neuroethological effects of growth hormone in birds are understudied, it has been linked to feeding behavior in poultry (Tachibana et al 2015). Growth hormone has been associated with behavioral and cognitive effects in mammals (Rollo et al 1999). Perhaps most interesting is that peripheral growth hormone administration promotes increased aggression and brain dopaminergic activity in fish (Johansson et al 2004).…”

Section: Similarities In Gene Expression Reflect the Role Of Testoste...mentioning

confidence: 99%

Neurogenomic landscape associated with status-dependent cooperative behavior

Bolton

Ryder

Dakin

et al. 2022

Preprint

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The neurogenomic mechanisms modulating cooperation are largely unknown, and previous work has been largely constrained to considering few genes in limited neurological space. Here we leverage transcriptomic and behavioral data on birds that perform cooperative courtship displays to better understand the mechanisms underlying cooperative behaviors. Males of the neotropical wire-tailed manakin (Pipra filicauda) form cooperative display coalitions, and their cooperative behaviors are modulated by testosterone in a status-specific manner: Testosterone promotes cooperation in non-territorial birds, but suppresses it in territory holders. To understand the neurogenomic basis of individual and status-specific regulation of cooperative display behavior, we profiled gene expression in 10 brain nuclei and two key endocrine tissues known to regulate social behavior. We associated gene expression with each bird's detailed behavioral and endocrine profile derived from years of repeated measures taken from free-living birds in the Ecuadorian Amazon. We found distinct landscapes of constitutive gene expression were associated with social status, testosterone phenotype, and cooperation, reflecting the modular organization and engagement of neuroendocrine tissues. Sex-steroid and neuropeptide signaling appear important in mediating status-specific relationships between testosterone and cooperation, and suggests shared regulatory mechanisms with male aggressive and sexual behaviors. We also find that systemic gene expression across the brain that could form the basis of social status-specific neuro-physical phenotypes, which are potentially mediated by testosterone and growth hormone. Overall, our findings provide new, systems-level insights into the mechanisms of cooperative behavior, and suggest differences in neurogenomic state form the basis for individual differences in behavioral phenotypes.

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The growth hormone axis and cognition: empirical results and integrated theory derived from giant transgenic mice

Cited by 17 publications

References 247 publications

A multi‐ingredient dietary supplement abolishes large‐scale brain cell loss, improves sensory function, and prevents neuronal atrophy in aging mice

A multi‐ingredient dietary supplement abolishes large‐scale brain cell loss, improves sensory function, and prevents neuronal atrophy in aging mice

Bovine growth hormone gene polymorphism affects stress response in Japanese Black cattle

Neurogenomic landscape associated with status-dependent cooperative behavior

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