2007
DOI: 10.1099/mic.0.2006/000190-0
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The haem–haemopexin utilization gene cluster (hxuCBA) as a virulence factor of Haemophilus influenzae

Abstract: Haemophilus influenzae has an absolute growth requirement for a porphyrin source, which can be supplied in vitro by haem, haemoglobin, or the haemoglobin-haptoglobin, haem-haemopexin and haem-albumin complexes. Utilization of the haem-haemopexin complex is known to be mediated by the products of the hxuCBA gene cluster. It was demonstrated that hxuC, but not hxuA or hxuB, is also essential for the utilization of haem from haem-albumin complexes. Mutants of the type b strain E1a lacking genes in the hxuCBA gene… Show more

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Cited by 50 publications
(56 citation statements)
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“…These proteins are essential for the utilization of hemoglobin-haptoglobin [9] and the age-related difference in virulence could be explained by hemoglobin-haptoglobin complexes becoming the predominant available heme source in 30-day old rats [14]. We have also recently reported age-related differences in virulence when comparing a type b strain with a mutant in the heme-hemopexin utilization genes (hxuCBA) [10].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…These proteins are essential for the utilization of hemoglobin-haptoglobin [9] and the age-related difference in virulence could be explained by hemoglobin-haptoglobin complexes becoming the predominant available heme source in 30-day old rats [14]. We have also recently reported age-related differences in virulence when comparing a type b strain with a mutant in the heme-hemopexin utilization genes (hxuCBA) [10].…”
Section: Discussionmentioning
confidence: 99%
“…Stock solutions were prepared as previously described [9,10]. Rabbit hemopexin was prepared as described previously [11].…”
Section: Heme Sourcesmentioning
confidence: 99%
See 1 more Smart Citation
“…Interestingly, several potential DsbA-dependent proteins that were not required in the lung model as determined by HITS are important for H. influenzae pathogenesis in other sites of infection. For example, the hemopexin utilization protein HxuA has been shown to be required for wild-type bacteremic levels in an infant rat model of H. influenzae type B infection (45), and the outer membrane protein P5 (OmpA) is required for virulence of NTHI in a chinchilla model of otitis media (62). This suggests that examination of the requirement for DsbA substrates in other H. influenzae infection models is likely to reveal additional mechanisms involved in pathogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Mutant genes with subtle effects on virulence, such as those with overlapping/redundant functions (e.g. genes involved Fe/Hm acquisition), often exhibit a significantly reduced ability to produce and sustain bacteraemia in weanling rats compared to infant rats (Seale et al, 2006;Morton et al, 2007aMorton et al, , b, 2009. For this reason we assessed the impact on virulence of the tehB deletion in both infant rats (5 days old) and weanling rats (30 days old) (Fig.…”
Section: Importance Of Tehb For Virulence In Rat Models Of Bacteraemiamentioning
confidence: 99%