The Hardy-Weinberg Principle

McMurran, Shawnee L.

doi:10.1080/10511970.2010.489544

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Furthermore, the local F 1 hybrid H1 demonstrated a close relationship when compared to parent 1, but H1 was characterized by its own unique bands,. Since these genotypes were closely related, it was possible that they shared alleles, which was demonstrated by McMurran (2010). The achieved results highlighted the higher genetic diversity of the two local F 1 hybrids compared to the commercial F 1 hybrid and the two parents.…”

Section: Discussionmentioning

confidence: 79%

Field Performance and DNA Fingerprint Identification of New Egyptian Eggplant F1 Hybrids

Samaha

Ibrahim

Glala

et al. 2023

Egyptian Journal of Horticulture

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T HIS study was undertaken to evaluate the field performance of the two newly promising bred eggplant F 1 hybrids (H1 and H2) relative to a commercial eggplant hybrid (Alabaster, C4) as a reference, as well as apply a dependable DNA fingerprinting technique (PCR-based, Inter Simple Sequence Repeat, ISSR markers) for identification and documentation of locally produced eggplant F 1 hybrids. Vegetative growth and yield parameters for H1, H2, and C4 eggplant hybrids were evaluated under four ecological conditions and in different geographic governorate locations (Giza "L-1", Menofia "L-2", Qalyubia "L-3" and El-Behaira "L-4") during the two growing seasons of 2020 and 2021 The means of locally produced eggplant F 1 hybrids (H1 and H2) exceeded or equaled the means of the reference hybrid (C4), especially under the conditions of Qalyubia (L3) and Giza (L1) for the characteristics of plant height, number of branches/plant, number of leaves/plant, early flowering, early fruit yield, total fruit yield, number of fruits/plant and the average fruit weight. Furthermore, nineteen ISSR primers were used to identify the genetic fingerprint of the above-mentioned hybrids (H1, H2 and C4) in addition to two local parental lines (P1 and P2). ISSR analysis revealed 243 distinct DNA amplified bands with polymorphic bands of 50.21%. The percentage of polymorphism ranged between 9% and 88% with an average level of 50%. The PIC value varied from 0.09 to 0.49 with an average of 0.36. Seven ISSR primers (HB12, 17899-A, UBC-844, UBC-892, UBC-895, ISSR-59 and ISSR-DAT) produced distinctive fingerprints associated with H1 hybrid. In the same context, eight primers (HB10, HB12, UBC-892, UBC-808, ISSR-55, ISSR-01, ISSR-59 and ISSR-DAT) were distinctive for H2 hybrid. While the commercial hybrid "C4" was distinguished by only three primers (UBC-850, UBC-881 and ISSR-9). The highest similarity value of 0.89 was found between P1 and H1, while the lowest value of 0.78 between P1 and H2. It may be concluded that local eggplant hybrids (H1 and H2) performed superiorly in most studied traits and displayed more polymorphisms than the commercial eggplant hybrid "C4".

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Section: Discussionmentioning

confidence: 79%

Field Performance and DNA Fingerprint Identification of New Egyptian Eggplant F1 Hybrids

Samaha

Ibrahim

Glala

et al. 2023

Egyptian Journal of Horticulture

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“…For genotyping and allele frequencies, WinPepi version 11.65 (Abramson, 2011) calculated the odd ratio, 95 percent confidence interval, and Fisher's exact probability. Use an online Hardy-Weinberg calculator (McMurran, 2010) for genotyping and allele frequency estimations.…”

Section: Discussionmentioning

confidence: 99%

Association between IL-23R rs11209026 Gene polymorphism and soluble interleukin 23 receptor (△9) in Iraqi patients with and without lupus nephritis

Allawe

Abdullah

Abed

2022

ijhs

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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by the uncontrolled formation of antibodies, overproduction of pro-inflammatory cytokines with a genetic background that is poorly understood. This case-control study comprised 80 SLE patients, SLE patients who met the American College of Rheumatology (ACR) criteria (40 SLE and 40 LN groups), and 40 healthy controls. All participants' serum IL-23R levels were determined using an enzyme-linked immunosorbent assay (ELISA). 40 patients (20 SLE and 20 LN groups) and 12 age- and sex-matched healthy controls were genotyped for IL-23R gene polymorphisms (rs11209026 G>A) by direct DNA sequencing. As for sIL-23R levels, the results showed non-significant differences between the groups of the patients (0.18(0.11-7.50) vs 0.17(0.12- 3.73) (P= 0.751) in SLE and LN, respectively) and the control group (0.17 (0.12-2.69) (P=0.713) vs (P=0.934) in SLE and LN, respectively). Analysis of the rs11209026 sequencing results showed that most patients and the control group share the same genotype, which is GG, and that the A allele is underrepresented in the studied groups, as the AA genotype did not appear in the results. Our results suggest that rs11209026 affects the production of the soluble form of IL-23R.

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“…For genotyping and allele frequency, the odds ratio, 95% confidence interval and Fisher's exact probability calculated by Windpipe version 11.65. 14 Online Hardy-Weinberg calculator 15 was also used for genotyping and allele frequency calculations.…”

Section: Statistical Analysesmentioning

confidence: 99%

The association between PON1 gene polymorphisms (Q192R and L55M) and nephrotic syndrome in Iraqi children

Ali

Baban

Ali

2021

Baghdad J. Biochem. Appl. Biol. Sci.

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Background: The role of paraoxonase 1 enzyme (PON1) and its single nucleotide polymorphisms (SNPs) in children with nephrotic syndrome (NS) has been reported previously in different ethnic and racial groups with divergent results. The human PON1 gene contains two coding region polymorphisms leading to two different PON1 isoforms. Objectives: The aim of the present study was to find out the association between the PON1 (Q192R and L55M) polymorphisms and their relation with serum PON1 activity as well as lipid profile tests (total cholesterol, TC; triglycerides, TG; high-density lipoprotein cholesterol, HDL-c; and low-density lipoprotein cholesterol, LDL-c) in children with NS. Methods: This study included a total of 80 participants (40 with NS in the age group of 2-14 years and 40 age and sex-matched healthy controls). The PON1 enzyme activity and lipid profile tests were measured in serum samples of all included participants. The PON1 genotype was determined by PCR-restriction enzyme fragment length polymorphism (PCR-RFLP) for both PON1 alleles (192 and 55) SNPs. Results: Our findings showed that the mean levels of lipid profile tests (TC, TG, LDL-c) were significantly increased in patients when compared with healthy controls (p<0.05), while the HDL-c concentration was significantly decreased in patients than that of controls. Also, the patients had significantly lower concentrations of PON1 when compared with the controls regardless of the genotype Q192R and L55M polymorphisms. Moreover, the homozygous RR genotype for PON1 SNP 192 and MM homozygous genotype for PON1 SNP 55 were significantly frequent in patients when compared with the controls. Conclusions: Our results support that the presence of the homozygous RR genotype for PON1 SNP 192 and MM homozygous genotype for PON1 SNP 55 were significantly higher in patients compared with the controls.

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The Hardy-Weinberg Principle

Cited by 4 publications

References 2 publications

Field Performance and DNA Fingerprint Identification of New Egyptian Eggplant F1 Hybrids

Field Performance and DNA Fingerprint Identification of New Egyptian Eggplant F1 Hybrids

Association between IL-23R rs11209026 Gene polymorphism and soluble interleukin 23 receptor (△9) in Iraqi patients with and without lupus nephritis

The association between PON1 gene polymorphisms (Q192R and L55M) and nephrotic syndrome in Iraqi children

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