1994
DOI: 10.1016/0091-3057(94)90542-8
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The head-twitch response in the least shrew (Cryptotis parva) is a 5-HT2− and not a 5-HT1C-mediated phenomenon

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Cited by 35 publications
(27 citation statements)
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“…Moreover, i.p. administration of the selective 5-HT 2A R agonist, DOI, produces the head-twitch response in the least shrew [61] but not emesis [Darmani, unpublished observation]. Likewise, at diverse doses, we tested the antiemetic potential of two selective 5-HT 6 R antagonists (Ro-046790 and Ro-04368554).…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, i.p. administration of the selective 5-HT 2A R agonist, DOI, produces the head-twitch response in the least shrew [61] but not emesis [Darmani, unpublished observation]. Likewise, at diverse doses, we tested the antiemetic potential of two selective 5-HT 6 R antagonists (Ro-046790 and Ro-04368554).…”
Section: Discussionmentioning
confidence: 99%
“…In rodent models, central administration of NK 1 receptor agonists induces a specific behavior analogous to foot-tapping in gerbils called scratching [43]. We had previously observed in the least shrew that the serotonergic 5-HT 2A receptor agonist DOI also induced centrally-mediated head-twitch and scratching behaviors analogous to those seen in DOI-treated rodents [11,62], which were sensitive to both 5-HT 2A and NK 1 receptor antagonists [11,12,62], and our preliminary studies indicated that i.p. injection of the NK 1 receptor agonist GR73632 can rapidly induce both emesis and scratching behavior in the least shrew.…”
Section: Introductionmentioning
confidence: 97%
“…In the current study, in addition to emesis, systemic administration of the brain-penetrating NK 1 receptor agonist GR73632 [25] in the least shrew concomitantly produced scratching behavior in a dose-dependent manner. This behavior, analogous to mouse ear-scratching, is mediated centrally in both rodents and shrews via the stimulation of NK 1 or serotonergic 5-HT 2A receptors [11,12,16,62]. The crosstalk between the two neurotransmitter systems is demonstrable, in that blockade of NK 1 receptors prevents serotonergically induced scratching and head-twitching behavior in mice [12].…”
Section: Behavioral Effects Of Substance P Relate To Cns Penetrationmentioning
confidence: 99%
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“…Quipazine also binds at 5-HT 1A and 5-HT 1B receptors and behaves as an agonist at these populations (Peroutka 1985;Schoeffter and Hoyer 1989). [It might be parenthetically noted that MD-354 seems to lack 5-HT 2A and 5-HT 1A agonist actions, since it failed to produce either the head-twitch response or the serotonin syndrome, which are considered to be functional models of 5-HT 2A and 5-HT 1A receptor activation, respectively (Darmani et al 1994;Darmani and Zhao 1999).] mCPBG is known to facilitate norepinephrine release (Schlicker et al 1994) and to interact with the dopamine transporter (Campbell et al 1995); it is not known at this time if MD-354 shares these actions.…”
Section: Discussionmentioning
confidence: 97%