The heart in acromegaly: an echocardiographic study

Csanády, Miklós; Gašpar, Ľudovít; Högye, M; Gruber, N

doi:10.1016/0167-5273(83)90006-2

Cited by 44 publications

(14 citation statements)

References 13 publications

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“…Previously our group described morphological alterations in the acromegalic heart [19]. In the present study increased aortic stiffness has been demonstrated in acromegalic patients, which was similar to subjects with significant CAD.…”

Section: Discussionsupporting

confidence: 85%

Aortic stiffness is increased in acromegaly — A transthoracic echocardiographic study

Nemes¹,

Gavallér²,

Csajbók³

et al. 2008

International Journal of Cardiology

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Section: Discussionsupporting

confidence: 85%

Aortic stiffness is increased in acromegaly — A transthoracic echocardiographic study

Nemes¹,

Gavallér²,

Csajbók³

et al. 2008

International Journal of Cardiology

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“…LV hypertrophy has been described in hypertensive [21, 22]as well as in normotensive patients, thus suggesting a possible independent anabolic effect of GH on the myocardium [23, 24]. Furthermore, alterations in LV function have been reported in acromegalic patients without any clinical signs of cardiac involvement, hypertension or coronary artery disease [24, 25].…”

Section: Discussionmentioning

confidence: 99%

Medium-Term Cardiovascular Effects of High-Dose Growth Hormone Treatment in Growth Hormone-Deficient Children

Radetti

Crepaz²,

Paganini³

et al. 1999

Horm Res Paediatr

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Aim: To investigate the possible cardiac morphofunctional alterations inducd by prolonged and high-dose GH therapy in a group of 14 children with isolated GH deficiency. Patients and Methods: Patients were evaluated at phase 1, after 1.1 ± 0.6 years of treatment with GH 0.93 ± 0.13 U/kg/week, and at phase 2, after 5.5 ± 2.1 years of therapy 0.89 ± 0.11 U/kg/week. At each phase left ventricular volume, mass and systolic function were evaluated by two-dimensional guided M-mode echocardiography; left ventricular diastolic function was assessed by PW-Doppler sampling of transmitral flow. Results: Phase 1: diastolic blood pressure was lower (p < 0.05) and fractional shortening was not adequate for the level of afterload (stress shortening index p < 0.05) in patients compared to controls. Phase 2: diastolic blood pressure was lower (p < 0.01) and mass and mass/volume ratio were increased (mass index p < 0.05, mass/ volume ratio p < 0.05) in patients compared to controls. The increased mass/volume ratio, together with the normal systolic blood pressure, explains the reduction in peak systolic stress (p < 0.005). Among the parameters of left ventricular diastolic function, the peak E velocity/total area under mitral valve tracing and the area under E velocity/total area under mitral value tracing ratios were significantly decreased (p < 0.05). Conclusion: After a mean period of 5 years on high-dose GH treatment in GH-deficient children, subclinical morphofunctional alterations in the left ventricle were found.

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“…Acromegaly is associated with a variety of car diovascular complications as a consequence of which an increased mortality may be ex pected. Hypertension is present in approxi mately 30% of acromegalic patients [4][5][6][7], Echocardiographic studies and autopsy series have confirmed the occurrence of myocardial hypertrophy and/or increased left ventricular mass also [6][7][8][9][10][11]. Some reports have de scribed patients who, in the absence of hyper tension or coronary artery disease, have car diac hypertrophy and diminished ventricular function [6,10].…”

Section: Introductionmentioning

confidence: 99%

“…Some reports have de scribed patients who, in the absence of hyper tension or coronary artery disease, have car diac hypertrophy and diminished ventricular function [6,10]. In the literature, most studies have used echographic methods to evaluate the cardiac function and involvement of the heart in acromegalic patients [6,[8][9][10][11][12][13][14]. By and large, these studies reported only ejection fraction (EF) and used only this quantity to evaluate the left ventricular functions.…”

Section: Introductionmentioning

confidence: 99%

“…Hypertension is present in approxi mately 30% of acromegalic patients [4][5][6][7], Echocardiographic studies and autopsy series have confirmed the occurrence of myocardial hypertrophy and/or increased left ventricular mass also [6][7][8][9][10][11]. Some reports have de scribed patients who, in the absence of hyper tension or coronary artery disease, have car diac hypertrophy and diminished ventricular function [6,10]. In the literature, most studies have used echographic methods to evaluate the cardiac function and involvement of the heart in acromegalic patients [6,[8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Left Ventricular Dysfunction in Acromegalic Patients Using Radionuclide Ventriculography Parameters

Erbaş

Erbaş²,

Usman

et al. 1992

Cardiology

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The left ventricular function of 14 acromegalic patients was investigated using radionuclide ventriculography. After labeling the red blood cells with 750-1,000 MBq ^99mTc-pertechnetate, ECG-triggered left anterior oblique images were recorded. Fourier analysis was then performed on the time-activity curve of the left ventricle. The ejection fraction (EF), peak ejection rate, time to peak ejection (TPE), time to endsystole (TES), peak filling rate (PFR), time to peak filling (TPF), 1/3 EF, 1/3 filling fraction (FF), TPE/T, TPF/T and TES/T values (T: time interval for one heart beat) were calculated for each patient. Five patients (35.7%) had clinical cardiovascular symptoms. A decreased EF was observed in 28.5% of the patients. In comparison to the control group, the EF (53.5 ± 5.5 vs. 60.8 ± 5%p < 0.009), 1/3 EF(14.45 ± 3vs.20 ± 4%, p < 0.001), 1/3 FF (28.5 ± 10.6 vs. 41 ± 11%, p < 0.02), TPE (158 ± 33 vs. 132 ± 35 msp < 0.01), TPE/T (20.2 ± 5 vs. 16 ± 3.7, p < 0.01) and PFR (2.4 ± 0.5 vs. 2.9 ± 0.4 EDC/s, p < 0.005) were significantly different. It was found that TPE was prolonged and the early ejection function was decreased. Diastolic dysfunction was found in 5 (35.7%) patients; 21.4% of the patients had decreased PFR values although they had no cardiac symptom, hypertension and/or cardiomegaly. Scintigraphic parameters did not correlate with the presence of hypertension, cardiomegaly or cardiovascular symptoms. In summary, using radionuclide ventriculography parameters, systolic and diastolic dysfunction were observed in 28.5 and 35.7% of acromegalic patients, respectively.

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The heart in acromegaly: an echocardiographic study

Cited by 44 publications

References 13 publications

Aortic stiffness is increased in acromegaly — A transthoracic echocardiographic study

Aortic stiffness is increased in acromegaly — A transthoracic echocardiographic study

Medium-Term Cardiovascular Effects of High-Dose Growth Hormone Treatment in Growth Hormone-Deficient Children

Assessment of Left Ventricular Dysfunction in Acromegalic Patients Using Radionuclide Ventriculography Parameters

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