The Helix-Loop-Helix Protein Id1 Controls Stem Cell Proliferation During Regenerative Neurogenesis in the Adult Zebrafish Telencephalon

Viales, Rebecca R.; Diotel, Nicolas; Ferg, Marco; Armant, Olivier; Eich, Julia; Alunni, Alessandro; März, Martin; Bally‐Cuif, Laure; Rastegar, Sepand; Strähle, Uwe

doi:10.1002/stem.1883

Cited by 69 publications

(120 citation statements)

References 56 publications

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“…Recent expression profiling of the lesioned spinal cord in adult zebrafish indicated a number of other microglia/macrophage related signals to be upregulated after injury, supporting a role for the immune system in spinal cord regeneration (Hui et al, 2014). It has to be noted that triggering an immune response with Zymosan is insufficient to induce expression of id1, a regulator of neurogenesis, suggesting a multitude of signals triggering regeneration (Rodriguez Viales et al, 2014).…”

Section: Types and Extent Of Neuronal Regeneration In The Cns Of Anammentioning

confidence: 99%

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Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!

Becker

2015

Developmental Cell

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Adult fish and salamanders regenerate specific neurons as well as entire CNS areas after injury. Recent studies shed light on how these anamniotes activate progenitor cells, generate the required cell types, and functionally integrate these into a complex environment. Some developmental signals and mechanisms are recapitulated during neuronal regeneration, whereas others are unique to the regeneration process. The use of genetic techniques, such as cell ablation and lineage-tracing, in combination with cell-type-specific expression profiling reveal factors that initiate, fine-tune, and terminate the regenerative response in anamniotes, with a view to translating findings to non-regenerating species.

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Section: Types and Extent Of Neuronal Regeneration In The Cns Of Anammentioning

confidence: 99%

“…Id1 function may converge on the Notch pathway as it binds to Notch downstream factors, such as Her4.1 protein (Rodriguez Viales et al, 2014).…”

Section: Reviewmentioning

confidence: 99%

Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!

Becker

2015

Developmental Cell

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“…(inhibitor of DNA binding 1, a transcription regulator), and also the estrogen-synthesizing enzyme, aromatase B (AroB), encoded by the cyp19a1b gene (Menuet et al, 2005;Tong et al, 2009;Diotel et al, 2010bDiotel et al, , 2015M€ arz et al, 2010;Dinarello, 2012;Coumailleau et al, 2015;Rodriguez Viales et al, 2015). In order to investigate the presence of 5hmC in radial glial cells, we took advantage of a cyp19a1b-GFP transgenic fish line in which GFP is expressed in radial glial cells.…”

Section: Neural Progenitors Do Not Display the 5hmc Mark In Adult Zebmentioning

confidence: 99%

5‐hydroxymethylcytosine marks postmitotic neural cells in the adult and developing vertebrate central nervous system

Diotel

Mérot

Coumailleau

et al. 2016

J of Comparative Neurology

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The epigenetic mark 5-hydroxymethylcytosine (5hmC) is a cytosine modification that is abundant in the central nervous system of mammals and which results from 5-methylcytosine oxidation by TET enzymes. Such a mark is suggested to play key roles in the regulation of chromatin structure and gene expression. However, its precise functions still remain poorly understood and information about its distribution in non-mammalian species is still lacking. Here, the distribution of 5hmC was investigated in the brain of adult zebrafish, African claw frog, and mouse in a comparative manner. We show that zebrafish neurons are endowed with high levels of 5hmC, whereas quiescent or proliferative neural progenitors show low to undetectable levels of the modified cytosine. In the brain of larval and juvenile Xenopus, 5hmC is also detected in neurons, while ventricular proliferative cells do not display this epigenetic mark. Similarly, 5hmC is enriched in neurons compared to neural progenitors of the ventricular zone in the mouse developing cortex. Interestingly, 5hmC colocalized with the methylated DNA binding protein MeCP2 and with the active chromatin histone modification H3K4me2 in mouse neurons. Taken together, our results show an evolutionarily conserved cerebral distribution of 5hmC between fish and tetrapods and reinforce the idea that 5hmC fulfills major functions in the control of chromatin activity in vertebrate neurons. J. Comp. Neurol. 525:478-497, 2017. © 2016 Wiley Periodicals, Inc.

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“…Therefore, zebrafish models are important to elucidate mechanisms which enable neuronal regeneration. Several studies have investigated the histological changes and molecular mechanisms during regeneration in the adult zebrafish telencephalon (Diotel et al, ; Kizil, Kyritsis, et al, ; Kroehne, Freudenreich, Hans, Kaslin, & Brand, ; Kyritsis et al, ; Viales et al, ). During neuronal regeneration in telencephalon, it was shown that radial glia (RG) function as neural stem cells (Baumgart, Barbosa, Bally‐Cuif, Götz, & Ninkovic, ; Diotel et al, ; Kroehne et al, ; Kyritsis et al, ).…”

Section: Introductionmentioning

confidence: 99%

Involvement of sonic hedgehog and notch signaling in regenerative neurogenesis in adult zebrafish optic tectum after stab injury

Ueda

Shimizu

et al. 2018

J of Comparative Neurology

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Unlike humans and other mammals, adult zebrafish have the superior capability to recover from central nervous system (CNS) injury. We previously found that proliferation of radial glia (RG) is induced in response to stab injury in optic tectum and that new neurons are generated from RG after stab injury. However, molecular mechanisms which regulate proliferation and differentiation of RG are not well known. In the present study, we investigated Shh and Notch signaling as potential mechanisms regulating regeneration in the optic tectum of adult zebrafish. We used Shh reporter fish and confirmed that canonical Shh signaling is activated specifically in RG after stab injury. Moreover, we have shown that Shh signaling promotes RG proliferation and suppresses their differentiation into neurons after stab injury. In contrast, Notch signaling was down-regulated after stab injury, indicated by the decrease in the expression level of her4 and her6, a target gene of Notch signaling. We also found that inhibition of Notch signaling after stab injury induced more proliferative RG, but that inhibition of Notch signaling inhibited generation of newborn neurons from RG after stab injury. These results suggest that high level of Notch signaling keeps RG quiescent and that appropriate level of Notch signaling is required for generation of newborn neurons from RG. Under physiological condition, activation of Shh signaling or inhibition of Notch signaling also induced RG proliferation. In adult optic tectum of zebrafish, canonical Shh signaling and Notch signaling play important roles in proliferation and differentiation of RG in physiological and regenerative conditions.

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The Helix-Loop-Helix Protein Id1 Controls Stem Cell Proliferation During Regenerative Neurogenesis in the Adult Zebrafish Telencephalon

Cited by 69 publications

References 56 publications

Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!

Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!

5‐hydroxymethylcytosine marks postmitotic neural cells in the adult and developing vertebrate central nervous system

Involvement of sonic hedgehog and notch signaling in regenerative neurogenesis in adult zebrafish optic tectum after stab injury

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