The hematopoietic stem cell diet

Wilkinson, Adam C.; Yamazaki, Satoshi

doi:10.1007/s12185-018-2451-1

Cited by 26 publications

(20 citation statements)

References 78 publications

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“…Therefore, in this study we restricted our analysis to KLS population which represents a mix population of stem and multipotent progenitor cells. Intriguingly, nutritional and metabolic interventions have also been suggested as treatments for disorders such as leukemia [ 64 ]. Elevated Vitamin C, known to support the absorption of non-heme iron in the gut, was shown to reduce leukemic progression while its depletion had the opposite effect [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Mineral and Amino Acid Profiling of Different Hematopoietic Populations from the Mouse Bone Marrow

Girotra

Monnard

Konz

et al. 2020

IJMS

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Steady hematopoiesis is essential for lifelong production of all mature blood cells. Hematopoietic stem and progenitor cells (HSPCs) found in the bone marrow ensure hematopoietic homeostasis in an organism. Failure of this complex process, which involves a fine balance of self-renewal and differentiation fates, often result in severe hematological conditions such as leukemia and lymphoma. Several molecular and metabolic programs, internal or in close interaction with the bone marrow niche, have been identified as important regulators of HSPC function. More recently, nutrient sensing pathways have emerged as important modulators of HSC homing, dormancy, and function in the bone marrow. Here we describe a method for reliable measurement of various amino acids and minerals in different rare bone marrow (BM) populations, namely HSPCs. We found that the amino acid profile of the most primitive hematopoietic compartments (KLS) did not differ significantly from the one of their direct progenies (common myeloid progenitor CMP), while granulocyte-monocyte progenitors (GMPs), on the opposite of megakaryocyte-erythroid progenitors (MEPs), have higher content of the majority of amino acids analyzed. Additionally, we identified intermediates of the urea cycle to be differentially expressed in the KLS population and were found to lower mitochondrial membrane potential, an established readout on self-renewal capability. Moreover, we were able to profile for the first time 12 different minerals and detect differences in elemental contents between different HSPC compartments. Importantly, essential dietary trace elements, such as iron and molybdenum, were found to be enriched in granulocyte-monocyte progenitors (GMPs). We envision this amino acid and mineral profiling will allow identification of novel metabolic and nutrient sensing pathways important in HSPC fate regulation.

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Section: Resultsmentioning

confidence: 99%

Mineral and Amino Acid Profiling of Different Hematopoietic Populations from the Mouse Bone Marrow

Girotra

Monnard

Konz

et al. 2020

IJMS

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“…Certainly, anemia associated with protein-energy malnutrition is relatively common in children and elderly people in general (9). The constant production of blood cells from hematopoietic stem cells (HCS) is also in uenced by the latter's microenvironment, a complex biological niche (10). In recent years, interest has grown in understanding the in uence of diet on the physiology and viability of HCS.…”

Section: Discussionmentioning

confidence: 99%

Severe Anemia in Patients with Propionic Acidemia is Associated with Low Plasma Levels of Valine, Isoleucine and Methionine

Stanescu¹,

Bélanger-Quintana²,

Quintero³

et al. 2020

Preprint

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Background. Propionic acidemia (AP), an inborn error of metabolism, is caused by a deficiency in propionyl-CoA carboxylase. Patients have to follow a diet restricted in the propiogenic amino acids isoleucine (Iso), valine (Val), methionine (Met) and threonine (Thr); proper adherence can prevent and treat acute decompensation and increase life expectancy. However, chronic complications occur in several organs even though metabolic control may be largely maintained. Bone marrow aplasia and cytopenia are among the more common. Materials and methods. In this retrospective study, data for patients with PA being monitored at the Hospital Ramón y Cajal (Madrid, Spain) (n=10) were examined to statistically detect relationships between hematological complications outside of metabolic decompensation episodes, and plasma amino acids provided by the diet, urinary organic acids and plasma odd-chain fatty acids. High ferritin levels were deemed to indicate that a patient had received repeated transfusions for severe anemia since data on hemoglobin levels at the moment of transfusion were not always passed on by the attending centers. Results. Three patients had severe, persistent anemia that required repeated blood transfusions leading to high ferritin levels. Their low plasma Val, Ile and Met suggested that their anemia had a nutritional component. Conclusion. The present results suggest that severe anemia in patients with PA is associated with low plasma levels of Val, Ile and Met.

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“…The hematopoietic system plays numerous essential roles in human health and disease. Failure to maintain homeostasis in the blood system results in a range of human diseases, including anemia, hemophilia, immunodeficiency, allergies, leukemia, and lymphoma [2].…”

Section: Introductionmentioning

confidence: 99%

Caseins as Regulators of Hematopoiesis

Ledesma‐Martínez¹,

Domínguez-Meléndez²,

Aguíñiga-Sánchez³

et al. 2020

Infant Feeding - Breast Versus Formula

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The main physiological role of casein, the main protein component in the milk, is to be a source of amino acids that are required for the growth of the neonate; therefore, casein is considered a highly nutritious protein. Over time, it has been revealed that casein is a protein whose physiological importance reaches levels far superior to the food field, having a wide array of biological activities including antimicrobial activities, facilitating absorption of nutrients, as well as acting as a growth factor and an immune stimulant. Here we analyze how caseins can exert numerous hematopoietic and immunomodulatory actions, their role in granulopoiesis, monocytopoiesis, and lymphopoiesis from the early stages of postnatal development seemingly throughout life, and we wonder if casein could be useful to fight pathogens resistant to antibiotics, inducing a strong immune response in immunosuppressed patients, or even be a prophylactic strategy to prevent infections.

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The hematopoietic stem cell diet

Cited by 26 publications

References 78 publications

Mineral and Amino Acid Profiling of Different Hematopoietic Populations from the Mouse Bone Marrow

Mineral and Amino Acid Profiling of Different Hematopoietic Populations from the Mouse Bone Marrow

Severe Anemia in Patients with Propionic Acidemia is Associated with Low Plasma Levels of Valine, Isoleucine and Methionine

Caseins as Regulators of Hematopoiesis

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