The herb medicine formula “Yang Wei Kang Liu” improves the survival of late stage gastric cancer patients and induces the apoptosis of human gastric cancer cell line through Fas/Fas ligand and Bax/Bcl-2 pathways

Li, Jie; Sun, Guizhi; Lin, Hongsheng; Pei, Yingxia; Qi, Xin; An, Cheng; Yu, Jun; Bai, Hua

doi:10.1016/j.intimp.2008.04.007

Cited by 25 publications

(21 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The enhanced induction of apoptosis in human gastric carcinoma cells can be observed after treatment with 5-Fluorouracil, Cisplatin, arsenous oxide and so on [5,6,10]. These data suggest that inducing cancer cell apoptosis should be a therapeutic method for gastric carcinoma.…”

Section: Discussionmentioning

confidence: 84%

“…Similar to the other malignant tumors, gastric carcinoma is always accompanying with abnormal cell proliferation and differentiation, as well as with abnormal apoptosis [5,6]. The enhanced induction of apoptosis in human gastric carcinoma cells can be observed after treatment with 5-Fluorouracil, Cisplatin, arsenous oxide and so on [5,6,10].…”

Section: Discussionmentioning

confidence: 95%

“…Therefore, a vaccine specifically targeting AFP is desirable. AFP oncofetal antigen is essential to the promotion and maintenance of cancer cell transformation, which could be an ideal target antigen for AFP vaccine [6,7]. However, AFP immunization has been restricted by improper antigen-specific immune reaction.…”

Section: Discussionmentioning

confidence: 99%

“…It has been clear that its extent is often enhanced in tumor by many anticancer drugs, such as cytotoxic drugs, hormone, or some Chinese herbal medicine [3][4][5]. Researches indicated that Chinese herbs could enhance apoptosis of human gastric cancer grafted in mice [5,6].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bioinformatics of Rhizoma Curcumae against Gastric Carcinoma Grafted on Mice

Lin¹,

Wang²,

Wang³

et al. 2017

Proceedings of the 7th International Conference on Education, Management, Information and Mechanical Engineering (EMIM 2017)

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bioinformatics of Rhizoma Curcumae against Gastric Carcinoma Grafted on Mice

Lin¹,

Wang²,

Wang³

et al. 2017

Proceedings of the 7th International Conference on Education, Management, Information and Mechanical Engineering (EMIM 2017)

View full text Add to dashboard Cite

“…We presumed that the herbs could activate the immune cells to attack the tumor cells as well as induce the apoptosis of the tumor cells directly [11,12]. The results showed that Shenfuweikang herbs could activate the immune cells to secret cytokines, IFN-γ and granzyme B, which are able to induce the apoptosis and necrosis of tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Biotherapy Effect of Shenfuweikang Herbs on Gastric Carcinoma

Wang¹,

Lin²,

Wang³

et al. 2016

Proceedings of the 2016 International Conference on Biomedical and Biological Engineering

View full text Add to dashboard Cite

Abstract. To study the biotherapy effect of Shenfuweikang herbs in treatment of gastric cancer, Kunming mice were grafted with a mouse gastric adenocarcinoma cell line MFC. Mice received different doses of Shefuweikang herbs after grafting. Tumor size was periodically measured and tumor weight was determined after the animals sacrificed. Apoptotic indices (AI) were examined by TUNEL assay and flow cytometric analysis. Serum cytokines IFN-γ and granzyme B were detected by ELISA. The anti-tumor effect was determined by the cytotoxic T-lymphocyte (CTL) assays. Our results demonstrated that Shefuweikang herbs could induce apoptosis and inhibit the growth of gastric cancer by activating the CTLs and eliciting the secretion of cytokines, IFN-γ and granzyme B. Our study suggests that Shefuweikang herbs inhibit the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells and activating the effects of immune cells, which may lay a better basis for further study on gastric cancer biotherapy.

show abstract

sFas levels increase in response to cisplatin‐based chemotherapy in lung cancer patients

Ulukaya

Acılan

Yilmaz

et al. 2010

Cell Biochemistry & Function

View full text Add to dashboard Cite

The Fas/Fas Ligand (FasL) system and survivin have counteracting roles in cell survival. Therefore, we explored the role of circulating soluble Fas (sFas) and the tissue levels of Fas and survivin with regard to response to chemotherapy in lung cancer patients. Serum samples from 52 lung cancer patients and 54 control subjects (19 benign lung disease and 35 healthy control subjects) were collected prior to and 24 and 48 h after chemotherapy. sFas was statistically significantly higher in the cancer group than that in the control groups (p < 0.001). Baseline (before chemotherapy) sFas values showed a statistically significant inverse correlation with overall survival (r = -0.599, p < 0.001). There was a significant increase in serum sFas levels 24 h after treatment (p < 0.05). Contrarily, tissue levels of Fas and survivin were not changed following the chemotherapy (p > 0,05). In conclusion, increased sFas may be an indicator of poor outcome in lung cancer patients. However, cisplatin-based chemotherapy may not be effective via neither the Fas/FasL system nor survivin pathway. Indeed, larger sample size is required for further evaluation.

show abstract

The herb medicine formula “Yang Wei Kang Liu” improves the survival of late stage gastric cancer patients and induces the apoptosis of human gastric cancer cell line through Fas/Fas ligand and Bax/Bcl-2 pathways

Cited by 25 publications

References 36 publications

Bioinformatics of Rhizoma Curcumae against Gastric Carcinoma Grafted on Mice

Bioinformatics of Rhizoma Curcumae against Gastric Carcinoma Grafted on Mice

Biotherapy Effect of Shenfuweikang Herbs on Gastric Carcinoma

sFas levels increase in response to cisplatin‐based chemotherapy in lung cancer patients

Contact Info

Product

Resources

About