The hidden cost of skin scars: quality of life after skin scarring

Brown, Benjamin; McKenna, SP; Siddhi, K.; McGrouther, DA; Bayat, Ardeshir

doi:10.1016/j.bjps.2008.03.020

Cited by 424 publications

(358 citation statements)

References 25 publications

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“…Thus, it is important to improve body image perception and deformity and dysfunction of the body in shaping the body image perception and self-esteem. The surgical treatment enhances self-confidence of the individual and influences the quality of life [1,2,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Facial Aesthetic and Reconstructive Surgeries on Patients’ Quality of Life

Yıldız

Şelimen

2014

Indian J Surg

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The aim of the present prospective and descriptive study was to assess the impact of facial aesthetic and reconstructive surgeries on quality of life. Ninety-one patients, of whom 43 had aesthetic surgery and 48 had reconstructive surgery, were analysed. The data were collected using the patient information form, body cathexis scale, and short form (SF)-36 quality of life scale. There were significant differences between before and after the surgery in both groups in terms of body cathexis scale and quality of life (p<0.05 for both). It was observed that problems regarding the body image perception were encountered more, and the quality of life was poorer in both aesthetic and reconstructive surgery patients before the surgery. However, the problems were decreased, and the quality of life was enhanced after the surgery. Among the parameters of SF-36 quality of life scale, particularly the mean scores of social functioning, physical role functioning, emotional role functioning, mental health, and vitality/fatigue were found low before the surgery, whereas the mean scores were significantly improved after the surgery. The results revealed that facial aesthetic and reconstructive surgical interventions favourably affected the body image perception and self-esteem and that positive reflections in emotional, social, and mental aspects were effective in enhancing selfconfidence and quality of life of the individual.

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Section: Introductionmentioning

confidence: 99%

The Impact of Facial Aesthetic and Reconstructive Surgeries on Patients’ Quality of Life

Yıldız

Şelimen

2014

Indian J Surg

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“…Burns, traumatic injuries, and surgical procedures produce exuberant scarring that is not only aesthetically displeasing, but can also be functionally disabling, causing patients both physical and psychological distress. 1,2 HTSs are linear or widespread in shape and generally red, elevated, and sometimes pruritic. 3 The presence of nodules in HTS is caused by a high density of cells and collagen.…”

mentioning

confidence: 99%

Therapeutic potential of fibroblast growth factor-2 for hypertrophic scars: upregulation of MMP-1 and HGF expression

Eto

Suga

Aoi

et al. 2012

Laboratory Investigation

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Although hypertrophic scars (HTSs) and keloids are challenging problems, their pathogenesis is not well understood, making therapy difficult. We showed that matrix metalloproteinase (MMP)-1 expression was downregulated in HTS compared with normal skin from the same patients, whereas type 1 and 3 collagen and transforming growth factor-b (TGF-b) were upregulated. These differences, however, were not seen in cultured fibroblasts, suggesting the involvement of microenvironmental factors in the pathogenesis of HTS. Fibroblast growth factor-2 (FGF-2) highly upregulated the expression of MMP-1 and hepatocyte growth factor (HGF) in both HTS-derived and control fibroblasts; the upregulation was reversed by extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) inhibitors. An animal study using human HTS tissue implanted into nude mice indicated that controlled-release FGF-2 resulted in significantly less weight and decreased hydroxyproline content in HTS. Degradation of collagen fibers in FGF-2-treated HTS was also confirmed histologically. Western blotting showed that FGF-2-treated HTS expressed significantly higher MMP-1 protein than control. Decreased MMP-1 expression may be an important transcriptional change in HTS, and its reversal as well as upregulation of HGF by FGF-2 could be a new therapeutic approach for HTS.

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“…They grow larger beyond the size of the original wounds, causing not only esthetic but also mental distress. 1 Keloid pathogenesis basically involves excessive wound healing with prolonged inflammation. Histopathologically, the infiltration of inflammatory cells, as well as irregular and excess accumulations of extracellular matrix components (eg, collagen, fibronectin, elastin, and proteoglycans) are observed.…”

mentioning

confidence: 99%

Identification and Characterization of Cartilage Oligomeric Matrix Protein as a Novel Pathogenic Factor in Keloids

Inui

Shono

Nakajima

et al. 2011

The American Journal of Pathology

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To elucidate pathogenic molecules in keloids, microarray analysis was performed using RNAs extracted from keloid-derived fibroblasts and normal skin-derived fibroblasts from the same patient with a typical keloid. Among 11 up-regulated extracellular matrix genes, cartilage oligomeric matrix protein (COMP) was most prominently increased. Up-regulation of COMP mRNA and protein was confirmed in the keloid tissue by quantitative RT-PCR and Western blot. Using immunohistochemistry, we compared 15 keloids and 6 control normal tissues using a COMPspecific antibody and found that COMP stained positively in 10 keloids (66.7%), whereas no staining was observed in normal tissues, demonstrating the ectopic expression of COMP in keloids. Comparing keloids smaller or larger than 10 cm 2 , the larger keloids were significantly more intensely stained with the COMP-specific antibody. Because COMP reportedly accelerates collagen type I fibril assembly, we examined whether extracellular type I collagen deposition is altered by silencing COMP mRNA by small interfering RNA (siRNA). Immunocytochemistry showed at 96 hours after transfection with COMP siRNA that the extracellular deposition of type I collagen was decreased compared to that observed with control siRNA. Further, COMP knockdown decreased amount collagens type I to V in the medium and on the cell surfaces. Our data suggest that COMP facilitates keloid formation by accelerating collagen deposition, thus providing a new therapeutic target.

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The hidden cost of skin scars: quality of life after skin scarring

Cited by 424 publications

References 25 publications

The Impact of Facial Aesthetic and Reconstructive Surgeries on Patients’ Quality of Life

The Impact of Facial Aesthetic and Reconstructive Surgeries on Patients’ Quality of Life

Therapeutic potential of fibroblast growth factor-2 for hypertrophic scars: upregulation of MMP-1 and HGF expression

Identification and Characterization of Cartilage Oligomeric Matrix Protein as a Novel Pathogenic Factor in Keloids

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