2024
DOI: 10.1021/acsptsci.4c00192
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The Hidden Hand in White Matter: Pericytes and the Puzzle of Demyelination

Siddharth Raj,
Priyabrata Sarangi,
Divya Goyal
et al.

Abstract: Disruption of myelin, the fatty sheath-insulating nerve fibers in the white matter, blocks or slows the rapid transmission of electrical signals along nerve cells and contributes to several neurodegenerative diseases such as multiple sclerosis. Traditionally, research has focused on neuronal dysfunction as the primary factor, including autoimmunity, infections, inflammation, and genetic disorders causing demyelination. However, recent insights emphasize the critical role of pericytes, non-neuronal cells that r… Show more

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