2023
DOI: 10.1038/s41579-023-00934-x
|View full text |Cite|
|
Sign up to set email alerts
|

The highly diverse antiphage defence systems of bacteria

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

1
92
0
1

Year Published

2023
2023
2024
2024

Publication Types

Select...
5
3
2

Relationship

1
9

Authors

Journals

citations
Cited by 178 publications
(94 citation statements)
references
References 142 publications
1
92
0
1
Order By: Relevance
“…Although we were able to characterize the molecular underpinnings of major features of the interaction network, we also note that more phenotypic and genomic variation exists which we have yet to explain, further highlighting the complexity that can evolve rapidly (i.e., within 100 to 200 generations). Although the molecular mechanisms identified in our flasks will differ across vastly different taxa and ecological communities ( 24 , 34 ), our work demonstrates how inherent coevolutionary processes can give rise to complex patterns that abound in natural ecosystems.…”
Section: Discussionmentioning
confidence: 93%
“…Although we were able to characterize the molecular underpinnings of major features of the interaction network, we also note that more phenotypic and genomic variation exists which we have yet to explain, further highlighting the complexity that can evolve rapidly (i.e., within 100 to 200 generations). Although the molecular mechanisms identified in our flasks will differ across vastly different taxa and ecological communities ( 24 , 34 ), our work demonstrates how inherent coevolutionary processes can give rise to complex patterns that abound in natural ecosystems.…”
Section: Discussionmentioning
confidence: 93%
“…Phage and bacteria are engaged in a constant arms race leading to the evolution of a multitude of non-mutually exclusive antiphage defence mechanisms, including the well-understood phage receptor alteration, restriction-modification, abortive infection, CRISPR-Cas systems, as well as new defence systems 45,46 . It is well established that increased phage virulence selects for the evolution of host resistance if the costs associated with resistance are outweighed by the benefits of the capability to avoid infection 47,48 .…”
Section: Discussionmentioning
confidence: 99%
“…They regularly attack and predate on bacterial populations across different ecological settings with an estimated rate of infection per second in oceans alone on the order of 10 23 (Mushegian, 2020;Suttle, 2007). To counteract phages and other parasitic mobile elements, bacteria evolved a wide range of defence systems with various molecular mechanisms of action (Bernheim et al, 2021;Doron et al, 2018;Gao et al, 2020;Georjon & Bernheim, 2023;Millman et al, 2022). These include CRISPR-Cas systems, which provide adaptive immunity by storing information about past encounters with MGE (Makarova et al, 2020), restriction-modification (RM) systems that degrade foreign genetic material based on specific molecular patterns (Wilson, 1991), abortive infection mechanisms that limit the spread of phages in the bacterial population by inducing the suicide of infected cells (Lopatina et al, 2020), and multiple others.…”
Section: Introductionmentioning
confidence: 99%