The HLA association with Graves' disease is sex‐specific in Hong Kong Chinese subjects

Cavan, David; Penny, M. A.; Jacobs, K. H.; Kelly, M. A.; Jenkins, David; Mijovic, C.; Chow, Chung Mo; Cockram, Clive S.; Hawkins, B. R.; Barnett, Anthony

doi:10.1111/j.1365-2265.1994.tb02444.x

Cited by 60 publications

(39 citation statements)

References 12 publications

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“…In Asian populations, the association of HLA with GD is less clear-cut from the reports in Japanese and Chinese with rather small number of patients (mostly Ͻ100) studied [12][13][14][15][16]. In Japanese, association with HLA-A2, B46, DRB1*0803, DRB1*1403, and DPB1*0501 [12][13][14], whereas in Hong Kong Chinese, association with HLA-B46, DR9, and DQB1*0303 [15,16], have been reported.…”

Section: Introductionmentioning

confidence: 71%

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Association of HLA-DR and -DQ Genes with Graves Disease in Koreans

Park

Song

et al. 2005

Human Immunology

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Section: Introductionmentioning

confidence: 71%

“…In Japanese, association with HLA-A2, B46, DRB1*0803, DRB1*1403, and DPB1*0501 [12][13][14], whereas in Hong Kong Chinese, association with HLA-B46, DR9, and DQB1*0303 [15,16], have been reported. Recently, association with A*0207, B*2704, B*4601, and DRB1*0901 in Taiwanese has been reported [17].…”

Section: Introductionmentioning

confidence: 91%

Association of HLA-DR and -DQ Genes with Graves Disease in Koreans

Park

Song

et al. 2005

Human Immunology

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“…The primary susceptibility genes have been associated to the human leukocyte antigen (HLA) class II region on chromosome 6p21 (DR3 region) by diverse studies with different ethnic groups [9][10][11][12][13][14]. Another gene extensively studied is the cytotoxic T lymphocyte-associated-4 (CTLA4) region on chromosome 2q33.…”

Section: Introductionmentioning

confidence: 99%

Analysis of thyroglobulin gene polymorphisms in patients with autoimmune thyroiditis

Caputo

Rivolta

Mories

et al. 2010

Endocr

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The autoimmune thyroid disease is a complex disorder caused by a combination of genetic susceptibility and environmental factors, which are believed to initiate the autoimmune response to thyroid antigens. Identification of the susceptibility genes has found that unique and diverse genetic factors are in association with Graves' disease and autoimmune thyroiditis. The thyroglobulin gene is an identified thyroid-specific gene associated to autoimmune thyroid disease and, principally, with autoimmune thyroiditis. The aim of this work was to test for evidence of allelic association between autoimmune thyroiditis and thyroglobulin polymorphism markers. We studied six polymorphisms distributed throughout all the thyroglobulin gene: four microsatellites (Tgms1, Tgms2, TGrI29 and TGrI30), one insertion/deletion (Indel) polymorphism (IndelTG-IVS18) and one exonic single nucleotide polymorphism (SNP) (c.7589G>A) in 122 patients with autoimmune thyroiditis compared with 100 non-related normal subjects. No differences in allele and genotype distribution were observed between autoimmune thyroiditis cases and controls for Tgms1, Tgms2, TGrI30, IndelTG-IVS18 and c.7589G>A. However, when we analyzed the patients with the TGrI29 microsatellite we found a significant association between the 199-bp allele and AT (33.7% vs. 24.5% in control group) (P = 0.0372). In addition, a higher prevalence of the 201-bp allele has been observed in control subjects (47.5% vs. 38.1% in patients group), although not statistically significant (P = 0.0536). Our work shows the association between the thyroglobulin gene and autoimmune thyroiditis and reinforce that thyroglobulin is a thyroid-specific susceptibility gene for this disease.

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“…Variable associations of HLA class II DR, DQ, and DP, especially DRB1, DQA1, and DQB1 loci, have been reported with autoimmune endocrine diseases such as type 1 DM, Addison’s disease, Graves’ disease, and Hashimoto’s thyroiditis [9,10,11,12,13,14,15,16,17,18]. Patients with APS II/III, who develop more than two autoimmune disorders, may be related to a combination of at least two closely related genes (haplotypes).…”

Section: Introductionmentioning

confidence: 99%

Susceptibility Alleles and Haplotypes of Human Leukocyte Antigen DRB1, DQA1, and DQB1 in Autoimmune Polyglandular Syndrome Type III in Japanese Population

et al. 2005

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Background: It has been reported that HLA class II haplotypes DRB1*0405-DQA1*0303-DQB1*0401 and DRB1*0901-DQA1*0302-DQB1*0303 are major susceptibility haplotypes for type 1 diabetes mellitus (DM) in Japanese population. However, little has been reported on the susceptibility HLA class II haplotypes in Japanese patients with autoimmune polyglandular syndrome type II and type III (APS III). Patients and Methods: HLA class II haplotypes of DRB1-DQA1-DQB1 in 31 patients with APS III, 14 patients with Hashimoto’s thyroiditis alone, and 15 patients with Graves’ disease alone were examined in Japanese population. APS III patients were divided into three groups (A, B, and C) depending on the combination of autoimmune endocrine diseases. Results: In 13 APS III patients with both Hashimoto’s thyroiditis and type 1 DM (group A), the haplotype frequencies of the HLA DRB1*0802-DQA1*0401-DQB1*0402 and DRB1*0901-DQA1*0302-DQB1*0303 were significantly higher than in the controls. In patients with Hashimoto’s thyroiditis alone, the haplotype frequency of DRB1*0901-DQA1*0302-DQB1*0303 was significantly higher than in controls, whereas the frequency of DRB1*0802-DQA1*0401-DQB1*0402 did not differ significantly from those in the controls. In 11 APS III patients with both Graves’ disease and type 1 DM (group B), the haplotype frequencies of HLA DRB1*0405-DQA1*0303-DQB1*0401 and DRB1*0802-DQA1*0301-DQB1*0302 were significantly higher than in controls. In patients with Graves’ disease alone, the haplotype frequency of DRB1*0803-DQA1*0103-DQB1*0601 were significantly higher than those in controls, suggesting that the susceptibility haplotypes for group B APS III differed from those for Graves’ disease alone. In 7 APS III patients with both autoimmune thyroid diseases and pituitary disorders (group C), the haplotype frequency of HLA DRB1*0405-DQA1*0303-DQB1*0401 was significantly higher than in controls. Conclusions: Susceptible HLA class II haplotypes of DRB1-DQA1-DQB1 for APS III differ between the Japanese and Caucasian populations. More interestingly, the susceptible HLA class II haplotypes differ among the three types of Japanese APS III and are not merely a combination of susceptibility haplotypes of each endocrine disease.

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The HLA association with Graves' disease is sex‐specific in Hong Kong Chinese subjects

Abstract: These findings call in question the role of HLA genes in disease susceptibility but suggest a role for HLA in protection from Graves' disease.

Cited by 60 publications

References 12 publications

Association of HLA-DR and -DQ Genes with Graves Disease in Koreans

Association of HLA-DR and -DQ Genes with Graves Disease in Koreans

Analysis of thyroglobulin gene polymorphisms in patients with autoimmune thyroiditis

Susceptibility Alleles and Haplotypes of Human Leukocyte Antigen DRB1, DQA1, and DQB1 in Autoimmune Polyglandular Syndrome Type III in Japanese Population

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