The HLA-C*06 allele as a possible genetic predisposing factor to psoriasis in South Indian Tamils

Abstract

Psoriasis is a multi-factorial heritable prototypical immune-mediated inflammatory disease, characterized by hyperproliferation of keratinocytes in the affected skin. There are no studies till date, to the best of our knowledge, about the association of HLA-C*06, the risk variant in the PSORS 1 susceptibility locus that confers the greatest risk for early onset of psoriasis, with the disease in South Indian Tamil patients with psoriasis. The present study was performed to determine the association of HLA-C*06 with psoriasis in the South Indian Tamil ethnic population. Three hundred and fifty-five cases of psoriasis and 360 healthy controls were included in this case-control study. Severity grading according to psoriasis area severity index (PASI) scoring was done in patients with psoriasis. PCR assays with sequence-specific primers (PCR-SSP) were used for specific detection of HLA-C*06. PCR with analysis of restriction fragment length polymorphism was used to distinguish between patients homozygous and heterozygous for HLA-C*06. We observed that those with the HLA-C*06-positive allele had a 3.5 times higher odds of having psoriasis compared to those without, [p < 0.0001, OR 3.5, 95 % CI (2.59-4.79)]. Among cases of psoriasis, it was noted that there was a significant association of HLA-C*06 positivity with female psoriatics [p = 0.006; OR 2.49 (1.28-4.87)] and early age of onset of psoriasis [p = 0.002; OR 2.04 (1.29-3.20)]. Our results suggest that the HLA-C*06 allele is positively associated with susceptibility to psoriasis, female gender and early onset of psoriasis in South Indian Tamils.

HLA-Cw6 and psoriasis

“…The worldwide HLA‐Cw6 allele frequency varies greatly and can range from 14·1% to 59·1%, whereas the percentage of patients with psoriasis carrying HLA‐Cw6 ranges from 10·5% to 77·2% (Table ) . Such wide ranges may be attributed to small sample sizes, ethnic diversity and differences in inclusion criteria.…”

“…They also have a significantly higher incidence of the Koebner phenomenon. In contrast, dystrophic nail changes and scalp involvement have been reported to be significantly less common in HLA‐Cw6 ‐positive patients . Interestingly, a recent meta‐analysis indicated that scalp lesions and nail psoriasis were associated with increased risk of developing PsA .…”

Benign Migratory Glossitis: Case Report and Literature Review

“…[7] Our patient demonstrated typical appearance and location of BMG, though it may occur on other sites of oral mucosa than on the dorsum of the tongue where it is called geographic stomatitis. [7,8] BMG is usually asymptomatic. However, itching, foreign body sensation, mild pain and mild to severe burning sensation, which may occasionally interfere with eating or sleeping, have also been reported.…”

Benign Migratory Glossitis: Case Report and Literature Review

“…Our patient demonstrated typical appearance and location of BMG, though it may occur on other sites of oral mucosa than on the dorsum of the tongue where it is called geographic stomatitis [7,8]. BMG is usually asymptomatic.…”