The House Mouse

Theiler, Karl

doi:10.1007/978-3-642-88418-4

Cited by 601 publications

(82 citation statements)

References 26 publications

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“…The gastrointestinal tract has diversified into the different organs--stomach, pancreas, duodenum, large and small intestine--by 14 days' gestation (see Theiler 1972). Thus, if Cdx-1 functions in intestinal tract cell differentiation, its action must be late in the terminal differentiation process.…”

Section: Discussionmentioning

confidence: 99%

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A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.

Duprey¹,

Chowdhury²,

Dressler³

et al. 1988

Genes & Development

196

112

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Section: Discussionmentioning

confidence: 99%

“…At 16 days p.c., the large and small intestines undergo pronounced cytodifferentiation. The villi of the small intestine increase in size and form columnar epithelium, whereas the villi of the large intestine form crypts (Theiler 1972). The phenotype of the intestinal epithelium must be maintained as these (Cheng and Leblond 1974).…”

Section: Discussionmentioning

confidence: 99%

A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.

Duprey¹,

Chowdhury²,

Dressler³

et al. 1988

Genes & Development

196

112

View full text Add to dashboard Cite

“…Pregnant females were killed by cervical dislocation and noon on the day of discovery of the vaginal plug was designated day 0.5 of development. Embryos were harvested, staged according to Theiler (1989) …”

Section: Experimental Procedures Animalsmentioning

confidence: 99%

Recombinant EDA or Sonic Hedgehog rescue the branching defect in Ectodysplasin A pathway mutant salivary glands in vitro

Wells

Mou

Headon

et al. 2010

Developmental Dynamics

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Hypohidrotic ectodermal dysplasia (HED) is characterized by defective ectodermal organ development. This includes the salivary glands (SGs), which have an important role in lubricating the oral cavity. In humans and mice, HED is caused by mutations in Ectodysplasin A (Eda) pathway genes. Various phenotypes of the mutant mouse Eda Ta/Ta , which lacks the ligand Eda, can be rescued by maternal injection or in vitro culture supplementation with recombinant EDA. However, the response of the SGs to this treatment has not been investigated. Here, we show that the submandibular glands (SMGs) of Eda Ta/Ta mice exhibit impaired branching morphogenesis, and that supplementation of Eda Ta/Ta SMG explants with recombinant EDA rescues the defect. Supplementation of Edar dlJ/dlJ SMGs with recombinant Sonic hedgehog (Shh) also rescues the defect, whereas treatment with recombinant Fgf8 does not. This work is the first to test the ability of putative Eda target molecules to rescue Eda pathway mutant SMGs. Developmental Dynamics 239:2674-2684,

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“…Sip1 flox(ex7)/ϩ ;␦EF1ϩ/Ϫ;Zp3-Cre female mice were crossed with doubleheterozygous males to obtain embryos with compound genotypes. Embryo stages are indicated according to Downs and Davies (1993) and Theiler (1989).…”

Section: Experimental Procedures Micementioning

confidence: 99%

Complementary expression pattern of Zfhx1 genes Sip1 and δEF1 in the mouse embryo and their genetic interaction revealed by compound mutants

Miyoshi

Maruhashi

Putte

et al. 2006

Developmental Dynamics

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In mouse embryos, the Zfhx1 transcription factor genes, Sip1 and ␦EF1, are expressed in complementary domains in many tissues. Their possible synergism in embryogenesis was investigated by comparing the phenotype of Sip1؊/؊;␦EF1؊/؊ double homozygotes with single homozygous embryos. Unexpectedly, in Sip1؊/؊ embryos ␦EF1 was ectopically activated, suggesting a negative regulation of ␦EF1 expression by Sip1. Sip1؊/؊;␦EF1؊/؊ embryos were similar to Sip1؊/؊ embryos in short somite production and developmental arrest around E8.5, but showed more severe defects in dorsal neural tube morphogenesis accompanied by a larger reduction of Sox2 expression, ascribable to the loss of the ectopic ␦EF1 expression. Sip1؉/؊;␦EF1؊/؊ embryos develop various morphological defects after E10 that were absent in ␦EF1؊/؊ embryos even in tissues without significant overlap of Sip1 and ␦EF1 expression, and arrested during mid gestation earlier than ␦EF1؊/؊ embryos. These findings indicate that complex synergistic interactions occur between Zfhx1 transcription factor genes during mouse embryogenesis. Developmental Dynamics 235: 1941-1952, 2006.

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The House Mouse

Cited by 601 publications

References 26 publications

A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.

A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.

Recombinant EDA or Sonic Hedgehog rescue the branching defect in Ectodysplasin A pathway mutant salivary glands in vitro

Complementary expression pattern of Zfhx1 genes Sip1 and δEF1 in the mouse embryo and their genetic interaction revealed by compound mutants

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