The Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal Master Regulator Twist

Domsch, Katrin; Schröder, Julia; Janeschik, Matthias; Schaub, Christoph; Lohmann, Ingrid

doi:10.1016/j.celrep.2020.108577

Cited by 9 publications

(4 citation statements)

References 47 publications

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“…When interacting with Pho, Ubx can stabilize lineage choice through suppressing the multipotency encoded in the genome [38]. Regulated by polycomb complex, Ubx is a repressor of alternative cell fates within the mesoderm, and it also maintains normal muscle differentiation by repressing Twi [39]. In this study, Ubx takes part in regulating fly sleep by cooperating with 14-3-3ε.…”

Section: Discussionmentioning

confidence: 77%

Integrative Role of 14-3-3ε in Sleep Regulation

Zhao

2021

IJMS

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Sleep is a crucial factor for health and survival in all animals. In this study, we found by proteomic analysis that some cancer related proteins were impacted by the circadian clock. The 14-3-3ε protein, expression of which is activated by the circadian transcription factor Clock, regulates adult sleep of Drosophila independent of circadian rhythm. Detailed analysis of the sleep regulatory mechanism shows that 14-3-3ε directly targets the Ultrabithorax (Ubx) gene to activate transcription of the pigment dispersing factor (PDF). The dopamine receptor (Dop1R1) and the octopamine receptor (Oamb), are also involved in the 14-3-3ε pathway, which in 14-3-3ε mutant flies causes increases in the dopR1 and OAMB, while downregulation of the DopR1 and Oamb can restore the sleep phenotype caused by the 14-3-3ε mutation. In conclusion, 14-3-3ε is necessary for sleep regulation in Drosophila.

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Section: Discussionmentioning

confidence: 77%

Integrative Role of 14-3-3ε in Sleep Regulation

Zhao

2021

IJMS

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“…In onychophorans, twist ( twi ), a conserved regulator of mesoderm development [ 117 – 122 ], is expressed in the mesoderm underlying the posterior pit (Fig. 7 ) [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

New insights into mesoderm and endoderm development, and the nature of the onychophoran blastopore

Janssen,

Budd

2024

Front Zool

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Background Early during onychophoran development and prior to the formation of the germ band, a posterior tissue thickening forms the posterior pit. Anterior to this thickening forms a groove, the embryonic slit, that marks the anterior–posterior orientation of the developing embryo. This slit is by some authors considered the blastopore, and thus the origin of the endoderm, while others argue that the posterior pit represents the blastopore. This controversy is of evolutionary significance because if the slit represents the blastopore, then this would support the amphistomy hypothesis that suggests that a slit-like blastopore in the bilaterian ancestor evolved into protostomy and deuterostomy. Results In this paper, we summarize our current knowledge about endoderm and mesoderm development in onychophorans and provide additional data on early endoderm- and mesoderm-determining marker genes such as Blimp, Mox, and the T-box genes. Conclusion We come to the conclusion that the endoderm of onychophorans forms prior to the development of the embryonic slit, and thus that the slit is not the primary origin of the endoderm. It is thus unlikely that the embryonic slit represents the blastopore. We suggest instead that the posterior pit indeed represents the lips of the blastopore, and that the embryonic slit (and surrounding tissue) represents a morphologically superficial archenteron-like structure. We conclude further that both endoderm and mesoderm development are under control of conserved gene regulatory networks, and that many of the features found in arthropods including the model Drosophila melanogaster are likely derived.

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“…It was recently shown that Ubx is involved in the muscle differentiation process by directly repressing the master mesodermal regulator twist (twi) (Domsch et al, 2021).…”

Section: Basics On Somatic/skeletal Muscle Developmentmentioning

confidence: 99%

“…It was recently shown that Ubx is involved in the muscle differentiation process by directly repressing the master mesodermal regulator twist ( twi ) ( Domsch et al, 2021 ). Here, a number of interesting points can be highlighted: (1) Ubx mesodermal downregulation interferes with abdominal embryonic muscle development because of failure to repress twi ; (2) twi repression is mediated by direct Ubx binding to the twi promoter region, competing with binding of the transcription factors Tinman (Tin) and Muscle enhancer factor 2 (Mef2), providing another promoter-based molecular evidence about the Hox muscle patterning mechanism; (3) even though Ubx binding displaces Tin on the twi promoter, Tin must be bound to the promoter for Ubx to be recruited, once again demonstrating a tight link between Hox and tissue-specific transcription factors for the correct patterning establishment.…”

Section: Somatic/skeletal Musculaturementioning

confidence: 99%

Hox Proteins in the Regulation of Muscle Development

Poliacikova

Maurel-Zaffran

Graba

et al. 2021

Front. Cell Dev. Biol.

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Hox genes encode evolutionary conserved transcription factors that specify the anterior–posterior axis in all bilaterians. Being well known for their role in patterning ectoderm-derivatives, such as CNS and spinal cord, Hox protein function is also crucial in mesodermal patterning. While well described in the case of the vertebrate skeleton, much less is known about Hox functions in the development of different muscle types. In contrast to vertebrates however, studies in the fruit fly, Drosophila melanogaster, have provided precious insights into the requirement of Hox at multiple stages of the myogenic process. Here, we provide a comprehensive overview of Hox protein function in Drosophila and vertebrate muscle development, with a focus on the molecular mechanisms underlying target gene regulation in this process. Emphasizing a tight ectoderm/mesoderm cross talk for proper locomotion, we discuss shared principles between CNS and muscle lineage specification and the emerging role of Hox in neuromuscular circuit establishment.

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The Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal Master Regulator Twist

Cited by 9 publications

References 47 publications

Integrative Role of 14-3-3ε in Sleep Regulation

Integrative Role of 14-3-3ε in Sleep Regulation

New insights into mesoderm and endoderm development, and the nature of the onychophoran blastopore

Hox Proteins in the Regulation of Muscle Development

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