The human biomonitoring study in Serbia: Background levels for arsenic, cadmium, lead, thorium and uranium in the whole blood of adult Serbian population

Stojsavljević, Aleksandar; Borković-Mitić, Slavica; Vujotić, Ljiljana; Grujičić, Danica; Gavrović-Jankulović, Marija; Manojlović, Dragan

doi:10.1016/j.ecoenv.2018.11.043

Cited by 33 publications

(19 citation statements)

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“…(2020) 10:3816 | https://doi.org/10.1038/s41598-020-60774-0 www.nature.com/scientificreports www.nature.com/scientificreports/ literature (0.014-0.015 µg/L) 33 . Our previous study showed the healthy Serbian population had 0.03 to 0.20 µg/L of U in whole blood samples 34 . Dodorov et al 35 reported U concentrations of 0.14 to 0.80 µg/L in the blood of veterans exposed to depleted U in Gulf War I. Al-Hamzaei et al 36 analyzed whole blood samples from inhabitants from several locations that were centers of intensive military activities during Gulf wars.…”

Section: Effects Of Toxic Metals On Brain Homeostasis This Study Demmentioning

confidence: 94%

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Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Stojsavljević

Vujotić

Rovčanin

et al. 2020

Sci Rep

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The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex-and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis. The importance of trace metals in the neurosciences has become more compelling during the first decade of the 21 st century 1 , as there is considerable interest in finding the relationships between trace metals and various neurological diseases, including central nervous system (CNS) malignancies. Metals show their harmful effects at the first stage of cancerogenesis (initiation) 2. Initiation can affect normal biochemical reactions, leading to alterations in metal profiles. Considering that trace metals play a significant role in neoplastic processes, the metal contents in neoplastic samples can differ from the composition in control ones 3. Homeostasis of metals within tight physiological limits is maintained through the mechanisms of uptake, distribution, accumulation, and secretion. Each breakdown has deleterious effects on metal-regulated metabolic pathways and can be a crucial step in the pathogenesis of various diseases. The most important pathway in metal-induced cancerogenesis is the ability of a metal to modulate gene expression by interfering with signal transduction pathways, leading to the deregulation of cell proliferation, activation of numerous transcription factors, disruption of cell cycle course, and apoptosis 4. Metal homeostasis is critical for the proper functioning of the brain 5. The brain is a target organ for toxic environmental pollutants 6. The balance of metals within the brain is regulated through the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier. In physiological conditions, these barriers regulate CNS homeostasis

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Section: Effects Of Toxic Metals On Brain Homeostasis This Study Demmentioning

confidence: 94%

“…The shaded fields indicate the place of residence of the individuals as well as the potential causes of U exposure. The image was modified according to Stojsaljević et al34 using Adobe Photoshop CS5 (Adobe Systems Incorporated, San Jose, CA, USA). (2020) 10:3816 | https://doi.org/10.1038/s41598-020-60774-0…”

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confidence: 99%

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Stojsavljević

Vujotić

Rovčanin

et al. 2020

Sci Rep

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“…Arsenic is a metal belonging to the nitrite group that is widely distributed in nature. It belongs to the toxic compounds to which most people from highly developed and/or developing countries, where economies are based largely on metallurgy, mining and agriculture, are exposed to (BIZOŃ et al, 2013;KULIK-KUPKA et al, 2016;STOJSAVLJEVIĆ et al, 2019). This is due to the fact that arsenic in minerals gets into the water, and the development of industry intensifies this process.…”

Section: Arsenicmentioning

confidence: 99%

The influence of high and low levels of arsenic in the human body on the process of carcinogenesis, based on function, expression and genetic polymorphisms in the genes encoding the two arsenic transporters - water channels AQP and glucose transporters glut (SLC2A)

et al. 2020

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Arsenic is a metallic element commonly found in soil, water and plants, and thereby can easily enter the food chain. When arsenic enters the body through food consumption, it subsequently passes into the cells through water channels (AQP) and glucose transporters (GLUT), where it may exert a various metabolic alterations including genotoxicity, which may finally promote carcinogenesis. However, there are human populations showing a reduced adverse effects of arsenic. This is mainly due to a natural selection caused by a long-term environmental exposure to a large doses of arsenic. Aquaporins AQP3, AQP7, AQP9, AQP10 and glucose transporters SLC2A1 (GLUT1), SLC2A4 (GLUT4) are considered as the candidate genes associated with resistance to arsenic in the carcinogenesis process as they are closely related to the occurrence of a various types of cancers, while their products are associated with arsenic transport.

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“…Typical biological matrices used for human biomonitoring are blood and urine, both for assessing occupational scenarios [7,8] and the general population [9][10][11]. In the last few decades, scalp hair has become an interesting bioindicator in various disciplines, such as the biological, medical, environmental, and forensic fields [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Occupational Exposure Assessment of Major and Trace Elements in Human Scalp Hair Among a Group of Eritrean Workers

Protano¹,

Astolfi

Marconi³

et al. 2019

Biol Trace Elem Res

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The aim of the study was to evaluate occupational exposure to 40 elements among a group of Eritrean adults employed at the Medeber metal market by analysing human scalp hair samples and by investigating the role of some predictors (gender, age, and body mass index-BMI) on their levels. Scalp hair samples were collected from 60 subjects (32 subjects working at the Medeber metal market and 28 subjects not working at Medeber and not employed in other industrial or artisanal activities) and were analysed through inductively coupled plasma mass spectrometry to determine the contents of 40 major and trace elements. Information on participants was collected via questionnaire. Significant differences were found in the hair levels of certain elements between subjects working at the Medeber metal market and subjects not exposed. In particular, working at the Medeber metal market increased hair levels of Be, B, Cu, Zn, Mo, Cd, Sb, Tl, Pb, and Fe from 25 to 100%, while reduced Na, K, and Rb levels from 30 to 50%. With multivariate adjustment for age, gender, and BMI, the results confirm that working at Medeber significantly increased the hair levels of Cu, Zn, Sb, Pb, and Fe. This finding reveals the need for more accurate and routine biomonitoring surveys and the necessity of health promotion campaigns both for local decision-makers and workers to increase health promotion and safety in this workplace.

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The human biomonitoring study in Serbia: Background levels for arsenic, cadmium, lead, thorium and uranium in the whole blood of adult Serbian population

Cited by 33 publications

References 33 publications

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

The influence of high and low levels of arsenic in the human body on the process of carcinogenesis, based on function, expression and genetic polymorphisms in the genes encoding the two arsenic transporters - water channels AQP and glucose transporters glut (SLC2A)

Occupational Exposure Assessment of Major and Trace Elements in Human Scalp Hair Among a Group of Eritrean Workers

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