The Human Body’s Own Language to be Considered for Safe and Effective Neurostimulation

Abstract

IntroductionThe general objective of this study was to provide an improved software for safer and more effective neurostimulation therapy.Materials and MethodsTulgar implants, employing combined modulation of stimulation synchronized with heart rate, breathing frequency, and position of the patient (HBP), were applied as vagus nerve stimulation (VNS) for the management of refractory epilepsy in 105 patients who were followed up for 1 year.ResultsFifty-nine out of 105 (56.19%) patients were seizure free, 34 (32.38%) patients had partial improvement in quality of life with a decrease in intensity and frequency of the seizures, and 12 (11.43%) patients did not respond to stimulation.DiscussionOther similar studies, undertaken with non-Tulgar equipment, reported a 10% full recovery, 60% partial improvement in quality of life, and 30% zero response. Comparisons of these results reveal an approximate fivefold increase in seizure freedom, and threefold decrease in the number of nonresponsive patients.ConclusionsThe findings of the present study imply that HBP-modulated mode of stimulation could be safer and more effective in neurostimulation, at least in VNS.

Vagus Nerve Stimulation for the management of depression: Rationale, anatomical and physiological basis of efficacy and future prospects

“…Metin Tulgar 1 , Erol Ozan 2* , Zafer Akan 3 Dear Editor, Treatment-resistant depression (TRD) is a major public health concern due to its high costs to society. One of the novel approaches for the treatment of depression is the Vagus Nerve Stimulations (VNS).…”

Sustainable Development of Polish Macroregions—Study by Means of the Kernel Discriminant Coordinates Method

“…If the authors of these papers chose, say, p features describing sustainable development of regions, then the obtained data were p -dimensional vectors or points in p-dimensional Euclidean space. Then, from these vectors numerical indicators (linear combinations) were constructed, considered to be the characteristics of the sustainable development of regions (Kontostanou-Karalivanou et al [ 10 ], United Nations [ 11 ], Streimikiene [ 12 ], Dočekalová et al [ 13 ], Jovovic et al [ 14 ], Roszkowska and Wyszkowska [ 15 ]). An extensive overview of sustainability performance evaluation, including a literature review and future directions, was presented by Büyüközkan and Karabulut [ 16 ], Krasławski et al [ 17 ].…”