The Human Electromyogram in Response to Nerve Stimulation and the Conduction Velocity of Motor Axons

Hodes, Robert; Larrabee, Martin G.; German, William McKee

doi:10.1001/archneurpsyc.1948.02310040011002

Cited by 264 publications

(93 citation statements)

References 17 publications

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“…Motor conduction was measured by using a similar technique to that of Hodes, Larrabee, and German (1948). The main median nerve trunk was stimulated at the wrist and the potentials, evoked from motor and sensory fibres (mixed conduction), were recorded at the elbow (Dawson and Scott, 1949).…”

Section: Stimulationmentioning

confidence: 99%

Electrodiagnosis of the carpal tunnel syndrome.

Kemble¹

1968

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Stimulationmentioning

confidence: 99%

Electrodiagnosis of the carpal tunnel syndrome.

Kemble¹

1968

Journal of Neurology, Neurosurgery & Psychiatry

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“…It is quite true that different shaped action potentials are recorded from different parts of large muscles when surface electrodes are used (13) and from different parts of small muscles when needle electrodes are used (14). However, we do not believe this to be an important factor in the present study since the surface electrodes we used practically covered the entire belly of the adductor pollicis muscle.…”

Section: Intraimus-cular Neostigmine (Lower 2 Lines)mentioning

confidence: 84%

Alterations in Muscle Tension Without Similar Changes in Electrical Activity in Patients With Myasthenia Gravis 1

Botelho¹

1955

J. Clin. Invest.

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Certain discrepancies between the electrical and mechanical activity of skeletal muscle in patients with myasthenia gravis have been pointed out previously ( 1 ). However, simultaneously recorded action potentials and tension have been reported only once in patients with this disorder (2) and no quantitative analysis has been made of the relationship between electrical and mechanical activity of skeletal muscle of patients with myasthenia gravis. The results of the present study of simultaneously recorded electrical and mechanical activity of intact muscle in six patients with myasthenia gravis indicate that changes in tension reflect more accurately the degree of muscle weakness than do changes in electrical activity and changes in contractile ability of the muscle can occur, both before and after neostigmine, without similar changes detectable in neuromuscular transmission. APPARATUS AND METHODSThe method and apparatus have been described in detail elsewhere (3). In brief, we recorded simultaneously action potentials from and isometric tension developed by the adductor pollicis muscle, which was induced to contract by supramaximal, percutaneous stimulation of the ulnar nerve at the elbow. We are cognizant of the fact that movements of the thumb are complex and therefore we might not be recording mechanical and electrical activity from the same group of muscles. However, an electrode on the belly of the adductor pollicis was certainly picking up electrical activity of muscles which are innervated by the ulnar nerve. When supramaximal stimuli were used potentials of duplicate single twitches, successive twitches with 3/sec. and successive responses with 30/sec. did not vary more than 10 per cent in 48 normal subjects. The same was true of tension. When the ulnar nerve is stimulated at the elbow, the hypothenar,

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“…La segunda fase del examen tuvo como objeto la medición de la velocidad de conducción motora y latencia residual en el nervio mediano; para ello se siguió la técnica descripta por Hodes, Larrabee y German (1948) 12 , utilizando un impulso cuadrado de 0,5ms de duración con intensidad supramáxima para la respuesta muscular evocada, liberado desde un electroestimulador Multistin modelo 13G04.…”

Section: Materials Y Métodosunclassified

Estudio electrofisiologico en la neuropatia por Vincristina

Sanz¹,

Colombi²,

Somoza³

et al. 1975

Arq. Neuro-Psiquiatr.

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El efecto tóxico de la vincristina y vinblastina sobre el nervio periférico es una de las complicaciones que más asiduamente se observa desde la introducción terapéutica de estas drogas como agentes citotóxicos 1 . 13 .Varios autores han analizado el tema desde ángulos diferentes observando una serie de hechos que apuntan hacia la presencia de participación del sistema nervioso en pacientes tratados con estas drogas 4 > 5 . 17 > 19 . Se describen como alteraciones precoces: pérdida de los reflejos tendinosos, generalmente acompañada de parestesias y disminución de la fuerza muscular. Bradley y col.4 > 5 observaron cambios electromicroscópicos en músculos proximales con disminución de su fuerza en pacientes en los cuales no había •evidencias electrofisiológicas de desorden muscular.Por lo tanto, de acuerdo a los autores citados, estas drogas tendrían más de un efecto a nivel fisiológico siendo difícil arrojar conclusiones sobre sus mecanismos de acción; sin embargo existen pruebas suficientes como para aceptar la acción de estos fármacos sobre el flujo axoplásmico. Bensch y Malawista 2 -3 observaron que la vinblastina y la vincristina interactúan con las proteínas microtubulares formando agregados paracristalinos interrumpiendo de esta manera el flujo trófico.El presente trabajo analiza, por métodos electrofisiológicos, el compromiso de la unidad motora en pacientes intoxicados con vincristina. MATERIAL Y MÉTODOSSe estudiaron dos mujeres y ocho hombres cuyas edades oscilaron entre los 28 y 57 años, con síntomas y signos de neuropatía periférica. Todos ellos se hallaban en tratamiento con vincristina en el momento del examen. El tiempo de recepción de la droga varió entre 1 y 36 meses; la dosis recibida osciló entre 7 y 48 mg.

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The Human Electromyogram in Response to Nerve Stimulation and the Conduction Velocity of Motor Axons

Cited by 264 publications

References 17 publications

Electrodiagnosis of the carpal tunnel syndrome.

Electrodiagnosis of the carpal tunnel syndrome.

Alterations in Muscle Tension Without Similar Changes in Electrical Activity in Patients With Myasthenia Gravis 1

Estudio electrofisiologico en la neuropatia por Vincristina

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