The Human Intestinal Microbiota and Microbiome

Koren, Omry; Ley, Ruth E.

doi:10.1002/9781118512074.ch32

Cited by 2 publications

(2 citation statements)

References 99 publications

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“…Acknowledgements.-We thank Peter Denton, Walter Winter, and an anonymous referee for useful comments. This work is supported by the Alfred P. As the manuscript was being completed, we became aware of a related but independent work [126].…”

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confidence: 99%

Neutrino Echoes from Multimessenger Transient Sources

Murase¹,

Shoemaker

2019

Phys. Rev. Lett.

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The detection of the high-energy neutrino event, IceCube-170922A, demonstrated that multimessenger particle astrophysics triggered by neutrino alerts is feasible. We consider time delay signatures caused by secret neutrino interactions with the cosmic neutrino background and dark matter and suggest that these can be used as a novel probe of neutrino interactions beyond the Standard Model (BSM). The tests with BSM-induced neutrino echoes are distinct from existing constraints from the spectral modification and will be enabled by multimessenger observations of bright neutrino transients with future experiments such as IceCube-Gen2, KM3Net, and Hyper-Kamiokande. The constraints are complementary to those from accelerator and laboratory experiments and powerful for testing various particle models that explain tensions prevailing in the cosmological data.

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confidence: 99%

Neutrino Echoes from Multimessenger Transient Sources

Murase¹,

Shoemaker

2019

Phys. Rev. Lett.

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“…Falcon polishes used SMRTlink 3.1 on the DNAnexus platform. Canu polishes used SMRTlink 3.1.1 on an SGE grid; see [66]. The N50 statistic shows the length of the shortest contig such that contigs of equal or greater length span at least half of some total, usually the assembly size.…”

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confidence: 99%

Analysis of theAedes albopictusC6/36 genome provides insight into cell line adaptations toin vitroviral propagation

Miller

Koren

Dilley

et al. 2017

Preprint

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BackgroundThe 50-year old Aedes albopictus C6/36 cell line is a resource for the detection, amplification, and analysis of mosquito-borne viruses including Zika, dengue, and chikungunya. The cell line is derived from an unknown number of larvae from an unspecified strain of Aedes albopictus mosquitoes. Toward improved utility of the cell line for research in virus transmission, we present an annotated assembly of the C6/36 genome.ResultsThe C6/36 genome assembly has the largest contig N50 (3.3 Mbp) of any mosquito assembly, presents the sequences of both haplotypes for most of the diploid genome, reveals independent null mutations in both alleles of the Dicer locus, and indicates a male-specific genome. Gene annotation was computed with publicly available mosquito transcript sequences. Gene expression data from cell line RNA sequence identified enrichment of growth-related pathways and conspicuous deficiency in aquaporins and inward rectifier K+ channels. As a test of utility, RNA sequence data from Zika-infected cells was mapped to the C6/36 genome and transcriptome assemblies. Host subtraction reduced the data set by 89%, enabling faster characterization of non-host reads.ConclusionsThe C6/36 genome sequence and annotation should enable additional uses of the cell line to study arbovirus vector interactions and interventions aimed at restricting the spread of human disease.

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The Human Intestinal Microbiota and Microbiome

Cited by 2 publications

References 99 publications

Neutrino Echoes from Multimessenger Transient Sources

Neutrino Echoes from Multimessenger Transient Sources

Analysis of theAedes albopictusC6/36 genome provides insight into cell line adaptations toin vitroviral propagation

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