The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development

Zhang, Jingyu; Wang, Xia; Chen, Bing; Xiao, Zhifeng; Li, Wenmei; Lü, Youyong

doi:10.3892/ol_00000081

Cited by 33 publications

(18 citation statements)

References 28 publications

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“…A similar result was found by Zhang et al. () in gastric cancer, correlating NANOG overexpression with the initial steps of gastric carcinogenesis (Zhang et al., ). Ye, Zhou, Cheng, Shen, and Chen () studied NANOG expression in normal cervical tissue, cervical tissue with dysplasia (mild, moderate, and severe), and cervical squamous cell carcinoma, and found higher expression of NANOG in dysplastic tissues than in normal tissues (Ye et al., ).…”

Section: Discussionsupporting

confidence: 87%

“…() found NANOG mainly located in the nucleus of rat embryonic cells (Liang et al., ). However, variations in intracellular distribution were found in different types of neoplasms as predominantly nuclear in OSCC, predominantly cytoplasmic in colorectal cancer cells, and both in gastric cancer cells (Chiou et al., ; Meng et al., ; Watanabe et al., ; Zhang et al., ). In this study, NANOG was found in both nucleus and cytoplasm with significant correlation between AC and LSCC cases, suggesting that nuclear and cytoplasmic expression would be coordinated and both would influence neoplastic progression.…”

Section: Discussionmentioning

confidence: 99%

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Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis

et al. 2018

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis

et al. 2018

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“…Due to and Nanog, reciprocal regulation of these proteins is suggested in governing pluripotency and self-renewal of ESCs . Interestingly, overexpression of OCT4 and Nanog has been shown in a gastric cell line and samples (Zhang et al, 2010;Huang et al, 2012). These data, along with SALL4 overexpression, which is reported here, lead us to hypothesize the existence of similar activated regulatory transcriptional networks in gastric cancer playing essential roles in proliferation and self-renewal characteristics of tumor cells.…”

Section: Discussionmentioning

confidence: 99%

ZNF797 plays an oncogenic role in gastric cancer

et al. 2014

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ABSTRACT. Human cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, selfrenewal. A complex network of transcription factors and signaling molecules are required for continuation of this trait. ZNF797 (SALL4) is a zinc finger transcriptional activator crucial for maintenance of self-renewal in stem cells; however, its expression level has not yet been elucidated in gastric tumor cells. Its expression was analyzed to determine this level and probable clinicopathological consequences. SALL4 expression in fresh tumor and distant tumor-free tissues from 46 colorectal samples was compared by real-time polymerase chain reaction. Greater than a 2-fold increase in SALL4 expression was detected in 89.5% of tumors vs normal related tissues. SALL4 expression was significantly correlated with tumor cell metastasis to lymph nodes, especially in moderately differentiated tumor samples (P < 0.05). Furthermore, higher levels of SALL4 mRNA expression were significantly associated with younger patients with tumor cells in stages I and II (P < 0.05). These results indicate a relationship between SALL4 expression and tumor cell metastasis to lymph nodes and consequent progression of tumors to advanced stages III and IV. Along with the promising evidence of its role in self-renewal in various cancers, SALL4 is introduced as a potentially interesting therapeutic target to reverse a number of aberrations that promote gastric tumor development and maintenance. This result may lead to new approaches for cancer therapy.

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“…It has been reported that 1-3 % of carcinogenic cells are CD133? and that these cells possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to their CD133-counterparts (Zhang et al 2010a). The present results support these observations, implying the potential of using CD133 as a CSC surface marker present on human tumoral specimens.…”

Section: Discussionmentioning

confidence: 97%

“…CD133 has been used as a marker to identify CSCs derived from primary solid tumors in the head and neck region (Zhang et al 2010a;Hsu et al 2011). Furthermore, expression of CD133 is a prognostic marker of survival in SCC (Zhang et al 2010b).…”

Section: W Limmentioning

confidence: 99%

Expression of cancer stem cell marker during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis

et al. 2014

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One of the theories regarding oral carcinogenesis is that the tumor growth is initiated from cancer stem cells (CSCs) that self-renew and give rise to differentiated tumor cells, like stem cells do in normal tissues. The most common methods of CSC identification are based on CSC marker expression in carcinogenesis. This study examined the expression of CD133 and CD44, the most commonly used CSC biomarkers in oral squamous cell sarcoma (SCC), with the goal of identifying molecular biomarkers whose expression is associated with the multistep oral carcinogenesis. The expression of CD133, CD44, proliferating cell nuclear antigen (PCNA), and Cytokeratin (CK) was examined by Western blot analysis and confirmed by immunohistochemistry in a 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis model. Also, the expression of aldehyde dehydrogenase 1 (ALDH1), OCT-4 and Nanog were investigated for alteration of cancer cell stemness by Western blot. Along with the progress of multistep carcinogenesis, there were slight increases of CD133 and CD44 expression in the dysplasia group compared with normal rats. However, CD133 protein level was significantly overexpressed in SCC. The expression of PCNA and CK were low in normal group, but sequentially increased in SCC. ALDH1, Nanog and OCT-4 expression were significantly increased according to SCC grade during carcinogenesis. The findings indicate that CD133 is useful in identifying oral CSCs, which suggests that CD133 may serve as a predictor to identify CSCs with a high risk of oral cancer development.

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The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development

Cited by 33 publications

References 28 publications

Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis

Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis

ZNF797 plays an oncogenic role in gastric cancer

Expression of cancer stem cell marker during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis

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