The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins [published erratum appears in J Cell Biol 1991 Feb;112(3):following 513]

Abstract

Abstract. The present study was undertaken to determine the relationship between the hyaluronate receptor and CD44 (H-CAM), cell-surface glycoproteins of similar molecular weights that have been implicated in cell adhesion. In initial experiments, a panel of monoclonal antibodies directed against CD44 were tested for their ability to cross react with the hyaluronate receptor. These antibodies immunoprecipitated [3H]hyaluronate binding activity from detergent extracts of both mouse and human cells, indicating that the hyaluronate receptor is identical to CD44. In addition, one of these antibodies (KM-201 to mouse CD44) directly blocked the binding of labeled hyaluronate to the receptor and inhibited hyaluronate dependent aggregation of SV-3T3 cells.

Podoplanin-mediated cell adhesion through extracellular matrix in oral squamous cell carcinoma

“…In contrast, the expression of CD44, a hyaluronan receptor of the cell membrane 29 and a possible interacting partner for PDPN, 18 at gene (Figure 4a) and protein (Figures 4b and c) levels, was obviously lower in siPDPN than that in the controls. As the change in expression levels for CD44 was in parallel with that of PDPN, we speculated that PDPN was also involved in hyaluronan-mediated cell adhesion.…”

Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study

“…It can directly increase proliferation, migration and activation of mesothelial cells to injured area 21 . A possible receptor for hyaluronic acid-mesothelial interaction is cluster of differentiation 44 22 . Hyaluronic acid also may influence the mesothelial fibrinolytic capacity in response to monocyte-macrophage system and tumor necrosis factor alpha 23,24 .…”

CD44: A Multitude of Isoforms with Diverse Functions

“…Several functions have been attributed to the CD44 standard molecule, like binding to high endothelial venules (HEV; Jalkanen et al, 1988), binding to collagen and fibronectin (Carter and Wayner, 1988;Jalkanen and Jalkanen, 1992) and binding to hyaluronic acid (HA; Aruffo et al, 1990;Culty et al, 1990;Miyake et al, 1990). …”

“…Studies with monoclonal antibodies revealed similarity, and most likely identity among these molecules (Omary et al, 1988;Gallatin et al, 1989;Picker et al, 1989;Aruffo et al, 1990;Miyake et al, 1990;Culty et al, 1990). When the human, baboon and murine cDNA sequences were established identity was confirmed.…”