The Hydrogen Ion in Normal Metabolism: A Review

Analysis and Interpretation of Microplate-Based Oxygen Consumption and pH Data

“…This topic has been considered several times in the wider physiological contexts of exercising muscle (B€ oning, Strobel, Beneke, & Maassen, 2005;Kemp, 2005;Robergs, Ghiasvanad, & Parker, 2004;Robergs & Parker, 2005), general metabolism (Alberti & Cuthbert, 1982), the ischemic heart (Dennis, Gevers, & Opie, 1991;Gevers, 1977), and energy metabolism of lower organisms (Busa & Nuccitelli, 1984;Hochachka & Mommsen, 1983). This topic has been considered several times in the wider physiological contexts of exercising muscle (B€ oning, Strobel, Beneke, & Maassen, 2005;Kemp, 2005;Robergs, Ghiasvanad, & Parker, 2004;Robergs & Parker, 2005), general metabolism (Alberti & Cuthbert, 1982), the ischemic heart (Dennis, Gevers, & Opie, 1991;Gevers, 1977), and energy metabolism of lower organisms (Busa & Nuccitelli, 1984;Hochachka & Mommsen, 1983).…”

“…Intracellular pH is kept within the range of homeostatic buffering capacities and is therefore essentially constant (Alberti & Cuthbert, 1982;Hochachka & Mommsen, 1983;McConnell et al, 1992;Zilva, 1978). When glucose-derived pyruvate is coupled to oxidative phosphorylation, there is normally a tight coupling between H + production and consumption in vivo.…”

The influence of pH on the corrosion rate of high-purity Mg, AZ91 and ZE41 in bicarbonate buffered Hanks' solution

“…However, some pH fluctuations in the body may be possible. During exercise, the metabolism of glucose causes the release of hydrogen ions [55], which would tend to decrease the blood pH. This decrease is compensated by the repository buffer system.…”

Acid‐sensing ion channels in neurones of the rat suprachiasmatic nucleus

“…Indeed SCN neurones exhibit in‐phase oscillation of Na + /K + ‐ATPase pump activity and firing activity (Wang & Huang, 2004) as well as daily metabolic rhythms in glucose uptake (Schwartz & Gainer, 1997) and ATP contents (Yamazaki et al 1994). ATP hydrolysis during energy metabolism produces H + (Alberti & Cuthbert, 1982) and causes extracellular acidification (Dmitriev & Mangel, 2004 and references herein) that may have effects on the external H + targets including the ASIC channels.…”