The Hypertension Optimal Treatment Study (The HOT Study): The Hot Study Group

Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer

“…Investigators reviewed 12 710 unique citations and 225 full-text articles for all KQs (Figure 2). Overall, 23 studies reported in 79 articles were included (N = 165 492 in RCTs; N = 870 660 in cohorts evaluating serious harms) . Three RCTs and 3 cohorts were newly identified in this update.…”

Behavioral Counseling to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors

“…Ninety-four randomized and cluster-randomized clinical trials reported in 227 publications were included (N = 52 174) (Figure 2; eTable 3 in the Supplement). Fifty-two trials were carried forward from the previous review…”