The <i>ADAM33</i> S2 Polymorphism Is Associated with Susceptibility to Pediatric Asthma in the Chinese Han Population

Fan, Jingang; Wang, Zhaoan; Zhao, Hong-Xiang

doi:10.1089/gtmb.2014.0332

Cited by 5 publications

(5 citation statements)

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“…Eight ADAM33 SNPs, including rs44707/T2, rs511898/F+1, rs528557/S2, rs612709/Q-1, rs2280089/T+1, rs2280091/T1, rs2787094/V4 and rs3918396/S1 have been reported to be associated with asthma in many of the world's mainland areas, and the majority of studies were performed on Caucasians and Asian individuals (10,11,(19)(20)(21). In the present study, genotyping of these eight ADAM33 SNPs was performed to evaluate the association with asthma in a Chinese Li population.…”

Section: Resultsmentioning

confidence: 99%

“…At present, >100 single-nucleotide polymorphisms (SNPs) of the ADAM33 gene have been reported to be associated with asthma or BHR (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). However, the data that demonstrate the association of ADAM33 SNPs with asthma were obtained from individuals living in mainland areas, who were predominantly Caucasian and Asian (10,11,(19)(20)(21) (22)(23)(24)(25). Therefore, in the present study, the prevalence and types of ADAM33 polymorphisms in the asthmatic individuals of the Li population were determined and compared with those in the control subjects.…”

Section: Introductionmentioning

confidence: 99%

“…At present, >100 single-nucleotide polymorphisms (SNPs) of the ADAM33 gene have been reported to be associated with asthma or BHR (7-18). However, the data that demonstrate the association of ADAM33 SNPs with asthma were obtained from individuals living in mainland areas, who were predominantly Caucasian and Asian (10,11,(19)(20)(21) …”

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ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population

et al. 2017

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Abstract. A disintegrin and metalloprotease 33 (ADAM33)is an asthma susceptibility gene that has been proven to be present in certain human populations. The Li population is a minority ethnic group, most of whom maintain a distinctive lifestyle on Hainan Island in southern China. To the best of our knowledge, no previous study has established whether ADAM33 polymorphisms are associated with asthma in the Li population. Therefore, the ADAM33 polymorphisms in a Li population were investigated in the present study. A total of 150 asthma patients and 100 healthy subjects were enrolled in the present study, and their DNA samples were evaluated to analyze eight single-nucleotide polymorphisms (SNPs) on the ADAM33 gene. Asthma patients were subcategorized into low and high severity groups, and their SNP data were compared with the data of the control subjects. Single-marker and haplotype association was analyzed to demonstrate the association between ADAM33 SNPs and asthma using multiple genetic statistic tests. The results indicated significant differences in allele frequencies at the SNPs rs44707/T2 (P=0.008), rs2787094/V4 (P=0.028) and rs2280089/T+1 (P=0.021) between asthma patients and control subjects. The SNP rs44707/T2 was also found to be associated with the high severity group (P=0.024), although SNPs rs2787094/V4 were associated with the low severity group (P=0.019). Two haplotypes, GGAGAGT and GAAGGGT, were significantly associated with asthma (P=0.003 and 0.008, respectively). To the best of our knowledge, this is the first time that SNP rs2280089/T+1 has been reported to be associated with asthma in an Asian population. These data confirm that ADAM33 polymorphisms are associated with asthma susceptibility in the Li population and confirm the uniqueness of the Li minority population within China. IntroductionAsthma is a chronic inflammatory disease of the airway. More than 100 million people across the globe suffer from this disorder (Global strategy for asthma management and prevention; http://www.ginasthma.org). Airway inflammation, bronchial hyperresponsiveness (BHR), and reversible airflow obstruction are the primary characteristics of asthma. Among these, airway inflammation is most closely associated with the clinical symptoms. Currently, genetic and environmental factors have been found to be involved in the generation of asthma pathologies. Thus, the potential contribution of genetic factors is considered to be an interesting area of clinical and basic research.The A disintegrin and metalloprotease 33 (ADAM33) gene is an asthma susceptibility gene, which was first reported by Van Eerdewegh et al (1). The ADAM33 gene is mapped to the short arm of chromosome 20p13 in the human genome, and is predominantly expressed in airway smooth-muscle cells and lung fibroblast cells, but not in epithelial cells, T cells or inflammatory leukocytes (2-6). ADAM proteins are involved in cell-cell and cell-matrix interactions (5), cell migration (2,3), cell-cell adhesion and signal transduction (4). The following are c...

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population

et al. 2017

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“…The included studies were published between 2010 and 2020 and conducted in 11 countries: China, Indian, Egypt, Jordan, Poland, Mexico, Saudi Arabia, Colombia, Chile, Turkey, and Tunisia. A total of 18 polymorphisms in 7 genes were identified for data synthesis: IL-13 +2044G/A (rs20541), [ 10 – 15 ] IL-13 -1112C/T (rs1800925), [ 11 , 13 , 15 – 19 ] IL-13 +1923C/T (rs1295686), [ 20 – 22 ] IL-4 - 590C/T (rs2243250), [ 12 , 15 – 19 , 21 , 23 – 28 ] ADRB2 -46 G /A (rs1042713), [ 11 , 15 , 21 , 29 – 37 ] ADRB2 -79G/C (rs1042713), [ 29 , 31 – 35 , 38 ] ADAM33 F+1 (rs511898), [ 39 – 42 ] ADAM33 V4 (rs2787094), [ 39 , 40 , 43 – 45 ] ADAM33 S2 (rs528557), [ 15 , 39 , 41 , 44 , 45 ] ADAM33 T2 (rs2280090), [ 40 , 43 – 46 ] ADAM33 T1 (rs2280091), [ 40 , 41 , 44 , 45 ] ADAM33 ST+4 (rs44707), [ 39 , 47 , 48 ] ORMDL3 rs7216389, [ 49 – 52 ] VDR Apa I (rs7975232), [ 53 – 59 ] VDR Fok I (rs2228570), [ 53 – 55 , 57 , 58 , 60 , 61 ] VDR ...…”

Section: Resultsmentioning

confidence: 99%

Asthma susceptible genes in children

et al. 2020

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“…The included studies were published between 2010 and 2020 and were conducted in ten countries: China, Indian, Egypt, Jordan, Poland, Mexico, Saudi Arabia, Colombia, Turkey and Tunisia. A total of 18 polymorphisms in 7 genes were identi ed for data synthesis: IL-13 + 2044G/A (rs20541) 10-14 , IL-13 -1112C/T(rs1800925) 11,13,15−18 , IL-13 + 1923C/T (rs1295686) 19,20 , IL-4 -590C/T (rs2243250) 12,15-18,20−25 , ADRB2 -46 G /A(rs1042713) 11,20,26−31 , ADRB2 -79G/C (rs1042713) 26,28−32 , ADAM33 F + 1(rs511898) 33-36 , ADAM33 V4 (rs2787094) 33,34,37−39 , ADAM33 S2(rs528557) 33,35,38,39 , ADAM33 T2 (rs2280090) 34,37−39 , ADAM33 T1(rs2280091) 34,35,38,39 , ADAM33 ST + 4 (rs44707) 33,40,41 , ORMDL3 rs7216389 42-44 , VDR Apa (rs7975232) [45][46][47][48][49] , VDR Fok (rs2228570) 45-47,49−51 ,VDR Bsm (rs1544410) [46][47][48][49]51 , VDR Taq (rs731236) [45][46][47]49 , and CTLA-4 + 49 G/A (rs231775) [52][53][54] . The detailed characteristics of included studies are given in Table 1.…”

Section: Study Inclusion and Characteristicsmentioning

confidence: 99%

Asthma susceptible genes in children: A meta-analysis

Ruan

Shi

Zhang

et al. 2020

Preprint

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Background: During the last decade, a number of studies have evaluated the potential association between some genetic polymorphisms and childhood asthma risk, however, the results of published studies appeared conflicts. The aim of the present study was to investigate association between genetic polymorphisms and pediatric asthma. Methods: Relevant studies were searched in PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang and Weipu database. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to access the strength of the associations. Results: 45 case-control studies were finally included in this meta-analysis. Eighteen SNPs were identified. Ten polymorphisms were found to be associated with asthma risk: IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4, ORMDL3 rs7216389, VDR ApaⅠ, VDR FokⅠ, VDR BsmⅠ. After subgroup analysis, IL-13 +2044G/A, ADAM33 T2, ADAM33 T1, VDR ApaⅠ, VDR BsmⅠ polymorphisms were associated with increased risk of asthma among Asian populations. IL-4 -590C/T polymorphisms may be related to asthma risk in Chinese children.Conclusions: This meta-analysis found that IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4, ORMDL3 rs7216389, VDR ApaⅠ, VDR FokⅠ and VDR BsmⅠ polymorphisms might be risk factors for childhood asthma. Further study with large population and more ethnicities is needed to estimate the associations.

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The ADAM33 S2 Polymorphism Is Associated with Susceptibility to Pediatric Asthma in the Chinese Han Population

Cited by 5 publications

References 33 publications

ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population

ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population

Asthma susceptible genes in children

Asthma susceptible genes in children: A meta-analysis

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