The I2C family from the wilt disease resistance locus I2 belongs to the nucleotide binding, leucine-rich repeat superfamily of plant resistance genes.

Ori, Naomi; Eshed, Yuval; Paran, Ilan; Presting, Gernot G.; Aviv, D.; Tanksley, S. D.; Zamir, Dani; Fluhr, Robert

doi:10.1105/tpc.9.4.521

Cited by 288 publications

(165 citation statements)

References 38 publications

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“…Some nucleotide-binding site/leucine-rich repeat (NBS/LRR)-type genes have been shown to confer a partial resistance (Ori et al 1997;Wang et al 1998). Calenge et al (2005) mapped 53 resistance gene analogues (RGAs) belonging to the NBS/LRR class of resistance genes (HammondKosack and Jones 1997) in apple.…”

Section: Discussionmentioning

confidence: 99%

Identification of a major QTL together with several minor additive or epistatic QTLs for resistance to fire blight in apple in two related progenies

Calenge¹,

Drouet²,

Denancé³

et al. 2005

Theor Appl Genet

120

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Although fire blight, caused by the bacterium Erwinia amylovora, is one of the most destructive diseases of apple (Malus · domestica) worldwide, no major, qualitative gene for resistance to this disease has been identified to date in apple. We conducted a quantitative trait locus (QTL) analysis in two F 1 progenies derived from crosses between the cultivars Fiesta and either Discovery or Prima. Both progenies were inoculated in the greenhouse with the same strain of E. amylovora, and the length of necrosis was scored 7 days and 14 days after inoculation. Additive QTLs were identified using the MAPQTL software, and digenic epistatic interactions, which are an indication of putative epistatic QTLs, were detected by two-way analyses of variance. A major QTL explaining 34.3-46.6% of the phenotypic variation was identified on linkage group (LG) 7 of Fiesta in both progenies at the same genetic position. Four minor QTLs were also identified on LGs 3, 12 and 13. In addition, several significant digenic interactions were identified in both progenies. These results confirm the complex polygenic nature of resistance to fire blight in the progenies studied and also reveal the existence of a major QTL on LG7 that is stable in two distinct genetic backgrounds. This QTL could be a valuable target in marker-assisted selection to obtain new, fire blight-resistant apple cultivars and forms a starting point for discovering the function of the genes underlying such QTLs involved in fire blight control.

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Section: Discussionmentioning

confidence: 99%

Identification of a major QTL together with several minor additive or epistatic QTLs for resistance to fire blight in apple in two related progenies

Calenge¹,

Drouet²,

Denancé³

et al. 2005

Theor Appl Genet

120

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“…Since then, several natural examples of plant-pathogen interactions resulting in resistance without cell death have been reported, in particular the potato Rx and barley Rrs1 disease resistance genes. [117][118][119][120][121][122][123][124] Additionally, suppressing caspase-like activities (unrelated to metacaspases) in plants inhibits pathogen-induced cell death without affecting disease resistance. 89,125 As described above, elimination of the metacaspase AtMC1 results in drastically reduced HR after infection with incompatible pathogens, but bacterial growth restriction remains unaffected in this mutant.…”

Section: The Type I Metacaspase Regulatory Module In Hrmentioning

confidence: 99%

Programmed cell death in the plant immune system

2011

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Cell death has a central role in innate immune responses in both plants and animals. Besides sharing striking convergences and similarities in the overall evolutionary organization of their innate immune systems, both plants and animals can respond to infection and pathogen recognition with programmed cell death. The fact that plant and animal pathogens have evolved strategies to subvert specific cell death modalities emphasizes the essential role of cell death during immune responses. The hypersensitive response (HR) cell death in plants displays morphological features, molecular architectures and mechanisms reminiscent of different inflammatory cell death types in animals (pyroptosis and necroptosis). In this review, we describe the molecular pathways leading to cell death during innate immune responses. Additionally, we present recently discovered caspase and caspase-like networks regulating cell death that have revealed fascinating analogies between cell death control across both kingdoms.

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“…The co-linear region of tomato chromosome 11 harbors the I2 locus conferring resistance to race 2 of F. oxysporum f. sp. lycopersici (Ori et al 1997;Simons et al 1998;Huang et al 2005). The Rm locus reported here was at a close genetic distances of 0.8 cM from the marker GP250.…”

Section: Discussionmentioning

confidence: 56%

“…The PVM resistance gene Rm is therefore a new member of this resistance gene cluster located on potato chromosome XI and the first one conferring resistance to a virus. Sequence analysis of the I2 locus in tomato (Ori et al 1997;Simons et al 1998) and the R3a locus in potato (Huang et al 2005) revealed a complex structure of clustered resistance gene homologs. Based on its position, the gene Rm could be another member of these gene families.…”

Section: Discussionmentioning

confidence: 99%

Potato chromosomes IX and XI carry genes for resistance to potato virus M

et al. 2006

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Two new loci for resistance to potato virus M (PVM), Gm and Rm, have been mapped in potato. The gene Gm was derived from Solanum gourlayi, whereas, Solanum megistacrolobum is the source of the gene Rm. Gm confers resistance to PVM infection after mechanical inoculation. Rm induces a hypersensitive response in potato plants. Two diploid populations segregating for Gm and Rm, bulked segregant analysis (BSA) using random amplified polymorphic DNA (RAPD) and inter-simple sequence repeat (ISSR), and available potato molecular maps were instrumental for mapping the resistance loci. The novel locus Gm was mapped to a central region on potato chromosome IX. The locus Rm was placed on the short arm of chromosome XI, close to the marker loci GP250 and GP283, where a hotspot for monogenic and polygenic resistance to diverse pathogens is located in the potato and tomato genome.

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The I2C family from the wilt disease resistance locus I2 belongs to the nucleotide binding, leucine-rich repeat superfamily of plant resistance genes.

Cited by 288 publications

References 38 publications

Identification of a major QTL together with several minor additive or epistatic QTLs for resistance to fire blight in apple in two related progenies

Identification of a major QTL together with several minor additive or epistatic QTLs for resistance to fire blight in apple in two related progenies

Programmed cell death in the plant immune system

Potato chromosomes IX and XI carry genes for resistance to potato virus M

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