“…ZNFX-1 contains an RNA helicase domain and a cysteine-rich zinc finger domain, while WAGO-4 is an Argonaute (AGO) protein that associates with the CSR-1 class of 22G-RNAs [2,3,27]. The intrinsically disordered region (IDR) containing protein PID-2, was recently identified as a Z granule component through a screen for defective Piwi-interacting RNA (piRNA) silencing [28]. While ZNFX-1 and WAGO-4 localize to Z granules, neither one is necessary for the assembly of Z granules.…”