The IgE and IgG subclass antibody response to foods in babies during the first year of life and their relationship to feeding regimen and the development of food allergy

Kemeny, David M.; Price, J. F.; Richardson, V F; Richards, David F.; Lessof, M. H.

doi:10.1016/0091-6749(91)90413-i

Cited by 44 publications

(22 citation statements)

References 30 publications

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“…Durante o primeiro ano de vida, o sistema imune expõe-se a uma ampla variedade de antígenos, sobretudo alimentares, os quais podem ativar a resposta imune mediada por IgG, IgA, IgM e IgE 42,43 . Além disso, a falta de atuação protetora da IgA secretora, ainda que transitória, também eleva o risco de exposição a tais antígenos, possibilitando atopia subseqüente 16 .…”

Section: Linfócitos Bunclassified

Imunidade relacionada à resposta alérgica no início da vida

Correa¹,

Zuliani²

2001

J. Pediatr. (Rio J.)

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Objective: given that the most common allergic manifestations (asthma, rhinitis, dermatitis, food allergies) occur during childhood, because the immune system can be induced into sensitization rather than into allergenic tolerance at the beginning of life, we analyzed the main immunological aspects of fetuses and infant in terms of allergic sensitization and response.Methods: detailed bibliographic revision concerning nonspecific immune response (physical and chemical barriers, myeloid cells) and specific immune response (T and B lymphocytes, cytokines) of the fetus and infant, with special attention to studies carried out in the last fifteen years.Results: various compartments of the immune system in fetuses and infants are different from those present in older children and adults. Thus, developmental aspects of nonspecific and specific immunity may contribute to atopic disease.Conclusions: atopic predisposition is determined at the beginning of life and seems to originate not only from genetic factors, but also from intrauterine environment and initial stage of childhood, inducing the immune system to increase the synthesis of IgE.J Pediatr (Rio J) 2001; 77 (6): 441-6: hypersensitivity, autoimmunity, natural immunity, cellular immunity, antibody formation. ResumoObjetivo: considerando-se que é na infância que as manifestações alérgicas mais comuns (asma, rinite, dermatite, alergia alimentar) ocorrem, porque é no início da vida que o sistema imune pode ser induzido à sensibilização ao invés de tolerância alergênica, analisamos as principais peculiaridades imunológicas do feto e da criança jovem, inerentes à sensibilização e resposta alérgica.Métodos: os autores realizaram revisão literária detalhada concernente à resposta imune inespecífica (barreiras físico-químicas, células mielóides) e específica (linfócitos T e B, citocinas) do feto e de crianças mais jovens, enfatizando os estudos mais relevantes nos últimos quinze anos.Resultados: vários compartimentos do sistema imune do feto e de crianças mais jovens são diferentes daqueles da criança maior e do adulto. Conseqüentemente, aspectos relativos ao desenvolvimento da imunidade inespecífica e específica, podem contribuir para a geração de atopia.Conclusões: a predisposição atópica determina-se no início da vida e parece originar-se, além dos fatores genéticos, por aqueles ocorridos no ambiente intra-uterino e fase inicial da infância, os quais influenciam o sistema imune à síntese elevada de IgE.J Pediatr (Rio J) 2001; 77 (6): 441-6: hipersensibilidade, autoimunidade, imunidade natural, imunidade celular, formação de anticorpos. Imunidade relacionada à resposta alérgica no início da vidaImmunity related to allergic response at the beginning of life Joaquina M.M. Correa 1 , Antonio Zuliani 2 As alergopatias resultam de uma conjunção de fatores genéticos (produção de células, citocinas e imunoglobulina E, por exemplo) e ambientais específicos (alérgenos) ou inespecíficos (tabagismo, infecções, exercícios, alterações psicossociais, tratamento e outros). T...

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Section: Linfócitos Bunclassified

Imunidade relacionada à resposta alérgica no início da vida

Correa¹,

Zuliani²

2001

J. Pediatr. (Rio J.)

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“…Optimal conditions for the ELISA method were established by various chessboard titrations following technical protocols published elsewhere (34).…”

Section: Patient Detailsmentioning

confidence: 99%

Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus

Oyama¹,

Chan²,

Neill³

et al. 2004

J. Clin. Invest.

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Lichen sclerosus is a common, acquired chronic inflammatory skin disease of unknown etiology, although circulating autoantibodies to the glycoprotein extracellular matrix protein 1 (ECM1) have been detected in most patients' sera. We have examined the nature of ECM1 epitopes in lichen sclerosus sera, developed an ELISA system for serologic diagnosis, and assessed clinicopathological correlation between ELISA titer and disease. Epitope-mapping studies revealed that lichen sclerosus sera most frequently recognized the distal second tandem repeat domain and carboxyl-terminus of ECM1. We analyzed serum autoantibody reactivity against this immunodominant epitope in 413 individuals (95 subjects with lichen sclerosus, 161 normal control subjects, and 157 subjects with other autoimmune basement membrane or sclerosing diseases). The ELISA assay was highly sensitive; 76 of 95 lichen sclerosus patients (80.0%) exhibited IgG reactivity. It was also highly specific (93.7%) in discriminating between lichen sclerosus and other disease/control sera. Higher anti-ECM1 titers also correlated with more longstanding and refractory disease and cases complicated by squamous cell carcinoma. Furthermore, passive transfer of affinity-purified patient IgG reproduced some histologic and immunopathologic features of lichen sclerosus skin. This new ELISA is valuable for the accurate detection and quantification of anti-ECM1 autoantibodies. Moreover, the values may have clinical significance in patients with lichen sclerosus.

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“…В дальнейшем выраженный иммун-ный ответ на БКМ и другие пищевые белки отмечается в первые месяцы жизни. Повышение уровня IgG, в том числе подкласса IgG1, является физиологической реак-цией на введение чужеродного белка [15,16]. Уровень специфических IgG-антител повышается в течение нескольких недель после введения в питание молочных смесей и достигает пика через 3-4 мес [15,16].…”

Section: в практику педиатраunclassified

“…Повышение уровня IgG, в том числе подкласса IgG1, является физиологической реак-цией на введение чужеродного белка [15,16]. Уровень специфических IgG-антител повышается в течение нескольких недель после введения в питание молочных смесей и достигает пика через 3-4 мес [15,16]. Спе ци-фи ческие IgE в небольшом количестве также являются частью физиологической реакции на чужеродные белки коровьего молока [17].…”

Section: в практику педиатраunclassified