The imbalanced expression of matrix metalloproteinases in nephrogenic systemic fibrosis

Kelly, Brent; Markle, Leslie Scroggins; Vickers, Jennifer; Petitt, Matthew; Raimer, S.; McNeese, Catherine

doi:10.1016/j.jaad.2009.09.006

Cited by 22 publications

(19 citation statements)

References 45 publications

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“…Lanthanides, like gadolinium, have been shown to enhance the polymerization of skin collagen (34,35). Reduced expression of the matrix metalloproteinase MMP-1 (interstitial collagenase), together with enhanced expression of its inhibitor (TIMP-1), has recently been proposed (36).…”

Section: Discussionmentioning

confidence: 99%

Skin Gadolinium Following Use of MR Contrast Agents in a Rat Model of Nephrogenic Systemic Fibrosis

Haylor

Schroeder²,

Wagner³

et al. 2012

Radiology

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Section: Discussionmentioning

confidence: 99%

Skin Gadolinium Following Use of MR Contrast Agents in a Rat Model of Nephrogenic Systemic Fibrosis

Haylor

Schroeder²,

Wagner³

et al. 2012

Radiology

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“…A recent article suggested that TGF-β1 activation may also occur by transglutaminase 2, which showed increased expression in NSF samples. 12 Other fibrosing conditions have been shown to express an imbalance in matrix metalloproteinase (MMP) expression and their corresponding inhibitors. 12 In a previous immunohistochemistrical study; while the MMP-1 expression was found to be nearly absent in all tested biopsy samples of the 16 NSF cases, MMP-2 and MMP-9 expression was variable but was increased compared to normal skin.…”

Section: Discussionmentioning

confidence: 99%

“…12 Other fibrosing conditions have been shown to express an imbalance in matrix metalloproteinase (MMP) expression and their corresponding inhibitors. 12 In a previous immunohistochemistrical study; while the MMP-1 expression was found to be nearly absent in all tested biopsy samples of the 16 NSF cases, MMP-2 and MMP-9 expression was variable but was increased compared to normal skin. 13 Thus targeting some of these cytokines may be important for the discovery of the future treatment options.…”

Section: Discussionmentioning

confidence: 99%

A Moderate Response to Plasmapheresis in Nephrogenic Systemic Fibrosis

Üstüner

Köse

Güleç

et al. 2011

Clinics and Practice

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Nephrogenic systemic fibrosis (NSF) is a recently identified idiopathic cutaneous fibrosing disorder that occurs in the setting of renal failure. The disease initially called nephrogenic fibrosing dermopathy is closely linked to exposure to gadolinium-based contrast media used during magnetic resonance imaging in patients with renal insufficiency. Although little is known about the pathogenesis of this disease, the increased expression of transforming growth factor-beta has been demonstrated recently. Herein, we present a case of NSF was partially treated due to a moderate and temporary response to plasmapheresis with no recurrence for 6 months, but returned at the end of 6th month.

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“…Metaloproteinazy macierzy pozakomórkowej i ich substraty [39][40][41] TIMP-2, TIMP-3, TIMP-4) i niespecyficznych inhibitorów (α2-makroglobuliny, α1-antytrypsyny, inhibitora plazminogenu 1) [45][46][47][48][49][50][51][52][53][54]. Szczególne znaczenie w formowaniu keloidów mają kolagenaza 1 (MMP-1) i żelatynazy (MMP-2 i MMP-9).…”

Section: Czynnik Wzrostu Tkanki łąCznejunclassified

Review papers Some molecular aspects of the fibroproliferative process in keloids

Antończak¹,

Jurzak²,

Adamczyk³

et al. 2015

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StreSzczenieProcesy naprawcze (reperatywne) uszkodzonych tkanek należą do podstawowych procesów biologicznych zapewniających utrzymanie homeostazy organizmu. Zasadniczo obejmują fazę zapalną, proliferacyjną oraz przebudowy. Końcowym efektem gojenia się uszkodzonych tkanek jest powstanie blizny. Nieprawidłowości w przebiegu gojenia się ran mogą być przyczyną tworzenia keloidów (bliznowców). W patofizjologii keloidów obserwuje się zarówno nieprawidłowości w migracji, proliferacji i apoptozie komórek, jak i w syntezie oraz sekrecji białek, cytokin, enzymów proteolitycznych degradujących składniki macierzy pozakomórkowej, a także ich inhibitorów. Dotychczasowo stosowane terapie nie przynoszą zadowalających efektów kosmetycznych. Obecnie prowadzone badania skupiają się na poszukiwaniu metod bezpośredniego hamowania procesu fibroproliferacyjnego poprzez modulowanie ekspresji cytokin, hamowanie proliferacji fibroblastów oraz regulowanie biosyntezy i degradacji składników macierzy pozakomórkowej. AbStrActReparation of damaged tissues is an essential biological process that ensures maintenance of homeostasis. Basically it includes phases of inflammation, proliferation and remodeling. The result of healing of damaged tissues is scar formation. Abnormalities in the course of wound healing may lead to keloid formation. The pathophysiology of keloids is characterized by improper migration, proliferation and apoptosis of cells as well as imbalanced synthesis and secretion of proteins, cytokines, proteolytic enzymes and their inhibitors. To date, applied therapeutic methods do not lead to satisfactory cosmetic results of the treatment. Current research focuses on developing methods for direct inhibition of the fibroproliferative process, mainly through modulation of cytokine expression and in consequence suppression of fibroblast proliferation and balancing of synthesis and degradation of extracellular matrix components.

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The imbalanced expression of matrix metalloproteinases in nephrogenic systemic fibrosis

Cited by 22 publications

References 45 publications

Skin Gadolinium Following Use of MR Contrast Agents in a Rat Model of Nephrogenic Systemic Fibrosis

Skin Gadolinium Following Use of MR Contrast Agents in a Rat Model of Nephrogenic Systemic Fibrosis

A Moderate Response to Plasmapheresis in Nephrogenic Systemic Fibrosis

Review papers Some molecular aspects of the fibroproliferative process in keloids

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