The Immun System Response İn Covıd-19 Infectıon İn Polycystıc Ovary Syndrome

Abstract

COVID-19, globally affecting people's lives, is a respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which reaches the pandemic state. People who are vulnerable and not immunocompromised are known to suffer severe COVID-19 complications and are at a relatively high risk of death. Risk factors include age, male gender, cardiovascular comorbidities including hypertension, history of cardiovascular disease, insulin resistance, diabetes, and obesity. Emerging data also linked the risk of severe COVID-19 to certain factors such as hyper inflammation, low vitamin D levels, and hyperandrogenism. Androgens play a key role in the pathophysiology of this infection. Therefore requires risk assessment of women with the polycystic ovarian syndrome (PCOS), the most common endocrinopathy in women of reproductive age with a prevalence of 8-13%, suffering from hyperandrogenism and characterized by most metabolic diseases. In this article, possible pathophysiological mechanisms related to the risk of COVID-19 in women with PCOS will be discussed. More scientific research is needed to understand which women are most at risk of becoming infected or developing complications, what causal mechanisms are possible to intervene, and what the long-term consequences will be.

Polycystic ovary syndrome and risks for COVID-19 infection: A comprehensive review

“…The pre-existing inflammatory condition in PCOS renders patients more susceptible to activating proinflammatory pathways in response to infections [198], irrespective of total fat mass [199]. Central obesity in PCOS with dysfunctional adipocytes correlates with marked adipose tissue overproduction of cytokines [17] and the chronic inflammatory state [18], favoring COVID-19 in women with PCOS [200].…”