The Immune Function and Measles Virus Infection in Three Different Socioeconomic Child Populations in Karachi, Pakistan

Terao, Keiji; M, Shahid; Ochikubo, Fumiko; Ahmed, Akhtar; Amjad, Muhammad; Sa, Qasmi; Su, Kazmi; Ds, Akran; Agboatwalla, M; Takasu, Toshiaki

doi:10.7883/yoken1952.47.87

Cited by 1 publication

(1 citation statement)

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“…[2][3][4][5] Seroconversion rates are lower when the vaccine is given before one year of age, 6 and malnutrition, gender and socioeconomic factors could be associated with the differences in immune responses. [7][8][9] Pakistan is one of 47 countries identified by the World Health Organization (WHO) with a high measles burden. Of the 19.1 million infants worldwide that WHO estimates did not receive measles immunization in 2010, 600 000 were in Pakistan.…”

Section: Introductionmentioning

confidence: 99%

Immune response to 1 and 2 dose regimens of Measles vaccine in Pakistani children

Hussain

Akram²,

Chandir

et al. 2013

vaccines

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Measles is a significant problem in Pakistan despite vaccine coverage rates reported at 80%. The purpose of this study was to determine the serologic response in children after one dose of measles vaccine at 9 mo versus two doses at 9 and 15 mo of age. From March through December 2006, children were enrolled from immunization clinics and squatter settlements in Karachi. Blood samples were taken from children in Group A at 9-10 mo of age prior to measles vaccine and 8 to 11 weeks later; from children in Group B at 16-17 mo of age after receiving 2 doses of measles vaccine; and from children in Group C who had received at least one dose of measles vaccine by 5 y of age. After the first dose of measles vaccine, 107/147 (73%) of children in Group A were seropositive, 157/180 (87%) of children in Group B were seropositive after two doses and 126/200 (63%) of children in Group C were seropositive at 5 y of age. The post-vaccination geometric mean antibody concentrations were higher in females than males in groups A (irrespective of pre-vaccination antibody levels) and B. The serologic response to one and two doses of measles vaccine was lower in children in Karachi than has been reported in many other countries. Two doses of vaccine were significantly better than one dose. An in-depth investigation is needed to determine the reason for the lower-than-expected protection rates. Differences in immunogenicity between genders need to be further studied. Recent introduction of supplemental measles vaccine doses should help control measles in Pakistan.

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