The immune system as a victim and aggressor in chronic obstructive pulmonary disease

McGrath, Joshua J.C.; Stämpfli, Martin R.

doi:10.21037/jtd.2018.05.63

Cited by 15 publications

(10 citation statements)

References 38 publications

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“…Alveolar macrophages exposed to long-term tobacco smoke increased IL1A or MCP-1 production, similar to BCG-induced trained macrophages. Promotion of the antimicrobial inflammatory response by these trained macrophages contributes to the exacerbation of chronic obstructive pulmonary disease (COPD) [ 113 ]. Thus, the therapeutic strategies targeting metabolic and epigenetic reprogramming in trained monocytes or macrophages can reverse abnormal macrophages in chronic inflammatory diseases [ 108 ].…”

Section: Innate Immune Memory Of Macrophages In Human Diseasesmentioning

confidence: 99%

Two Faces of Macrophages: Training and Tolerance

et al. 2021

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Macrophages are present in almost all body tissues. They detect and quickly respond to “environmental signals” in the tissue. Macrophages have been associated with numerous beneficial roles, such as host defense, wound healing, and tissue regeneration; however, they have also been linked to the development of diverse illnesses, particularly cancers and autoimmune disorders. Complex signaling, epigenetic, and metabolic pathways drive macrophage training and tolerance. The induced intracellular program differs depending on the type of initial stimuli and the tissue microenvironment. Due to the essential roles of macrophages in homeostatic and their association with the pathogenesis of inflammatory diseases, recent studies have investigated the molecular mechanisms of macrophage training and tolerance. This review discusses the role of factors involved in macrophage training and tolerance, along with the current studies in human diseases.

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Section: Innate Immune Memory Of Macrophages In Human Diseasesmentioning

confidence: 99%

Two Faces of Macrophages: Training and Tolerance

et al. 2021

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“…The therapies explored include phosphodiesterase 4 inhibitors, kinase inhibitors, adenosine A2a-receptor agonists, and agents that interfere with adhesion molecules. [ 35 ] Still, there are concerns about the immune system dysfunction recently found in COPD patients, [ 36 ] because an impaired neutrophilic response may increase the susceptibility to infectious disease.…”

Section: Anti-neutrophilic Inflammatory Strategies For Copdmentioning

confidence: 99%

Sialic acid-binding immunoglobulin-like lectin 9 as a potential therapeutic target for chronic obstructive pulmonary disease

Chen

et al. 2021

Chinese Medical Journal

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Chronic obstructive pulmonary disease (COPD) has become the third-leading cause of death worldwide, which is a severe economic burden to the healthcare system. Chronic bronchitis is the most common condition that contributes to COPD, both locally and systemically. Neutrophilic inflammation predominates in the COPD airway wall and lumen. Logically, repression of neutrophilia is an essential fashion to COPD treatment. However, currently available anti-neutrophilic therapies provide little benefit in COPD patients and may have serious side effects. Thus, there is an urgent need to explore an effective and safe anti-neutrophilic approach that might delay progression of the disease. Sialic acid-binding immunoglobulin-like lectin (Siglec)-9 is a member of the Siglec cell surface immunoglobulin family. It is noteworthy that Siglec-9 is highly expressed on human neutrophils and monocytes. Ligation of Siglec-9 by chemical compounds or synthetic ligands induced apoptosis and autophagic-like cell death in human neutrophils. Furthermore, administration of antibody to Siglec-E, mouse functional ortholog of Siglec-9, restrained recruitment and activation of neutrophils in mouse models of airway inflammation in vivo . Given the critical role that neutrophils play in chronic bronchitis and emphysema, targeting Siglec-9 could be beneficial for the treatment of COPD, asthma, fibrosis, and related chronic inflammatory lung diseases.

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“…These inflammatory cells release proteolytic enzymes (matrix metalloproteinases, neutrophil elastase) contributing to the destruction of lung tissue, along with TGF-β1 that is involved in the processes of airway remodeling. 13 Using human bronchial cell culture, Pace et al have shown that TLR4/MyD88 signaling plays a key role in the initiation of immune response to exposure to cigarette smoke. The main result of the activation of this signaling pathway is the synthesis of the neutrophil chemoattractant C-X-C Motif Chemokine Ligand 8/interleukin-8 (CXCL8/IL-8).…”

Section: Tlr2 and Tlr4 In The Initiation Of Inflammation In Copdmentioning

confidence: 99%

“…They are involved in the pathogenesis of this disease in several ways. [10][11][12][13] The aim of the review is to analyze the modern views on the role of TLR2 and TLR4 in the pathogenesis of COPD.…”

Section: Introductionmentioning

confidence: 99%

<p>The Role of Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease</p>

Sidletskaya

Виткина

Denisenko

2020

COPD

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Currently, chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. The determination of immune mechanisms of inflammation in the disease presents an important challenge for fundamental medical research. According to modern views, Toll-like receptors (TLRs), among which TLR2 and TLR4 play a key role, are one of the essential components of inflammatory process in COPD. This review focuses on following aspects: the role of TLR2 and TLR4 in the initiation of inflammatory process in COPD; the mechanisms of influence of various exogenous factors (cigarette smoke, suspended particulate matter, and bacteria) on the expression of TLR2 and TLR4; the contribution of these TLRs to the T-helper (Th) immune response development in COPD, in particular to the Th17 immune response, which contributes to the progression of the disease and therapeutic implications of TLR2 and TLR4 in COPD.

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The immune system as a victim and aggressor in chronic obstructive pulmonary disease

Cited by 15 publications

References 38 publications

Two Faces of Macrophages: Training and Tolerance

Two Faces of Macrophages: Training and Tolerance

Sialic acid-binding immunoglobulin-like lectin 9 as a potential therapeutic target for chronic obstructive pulmonary disease

<p>The Role of Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease</p>

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