The immune system is limited by oxidative stress: Dietary selenium promotes optimal antioxidative status and greatest immune defense in pacu Piaractus mesopotamicus

Biller-Takahashi, Jaqueline Dalbello; Takahashi, Leonardo Susumu; Mingatto, Fábio Ermínio; Urbinati, Elisabeth Criscuolo

doi:10.1016/j.fsi.2015.09.022

Cited by 90 publications

(58 citation statements)

References 53 publications

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“…In addition, MPX, a mediator of oxidative innate immune defense in zebrafish, is expressed in neutrophils during embryonic development in zebrafish, functioning as an ROS scavenger (van der Vaart et al, 2012). Moreover, SOD, CAT and GPx are antioxidants that repair or prevent ROS damage of macromolecular structures and participate in innate immune defense against immunostimulants (Biller-Takahashi et al, 2015;Liu et al, 2010). Previous study shows that anti-oxidant relevant genes may be induced in fish to fight infection , and this was confirmed by our results in F1 control larvae with bacterial and viral mimic exposure.…”

Section: Discussionmentioning

confidence: 99%

“…We selected the following genes that are expressed exclusively in the immune system: toll-like receptors (TLRs) and downstream signaling molecule mRNA such as myeloid differentiation factor 88 (MyD88), Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF), inflammatory cytokines including type I interferon (IFN), myxovirus-resistance gene (Mx), tumor necrosis factor α (TNFα) and interleukin-1β (IL-1β), and matrix metalloproteinases (MMP) (Li et al, 2017;Liao et al, 2016;Medzhitov, 2001). Oxidative defense is involved in immune response (Biller-Takahashi et al, 2015), so myeloperoxidase (MPX), and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) mRNA expression was measured. Recombination-activating genes (RAGs) in immature T and B lymphocytes were also measured.…”

Section: G R a P H I C A L Abstractmentioning

confidence: 99%

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Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity

Dong

Zhang

Meng

et al. 2018

Science of The Total Environment

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Transgenerational effects of environmental pollutants on humans and animals are complex. Thus, we used zebrafish to evaluate the effects of parental whole-life cycle exposure to bisphenol A and its analogs (bisphenol S and F) on offspring innate immunity. At adulthood, offspring were examined with/without continued chemicals treatment until 72h post-fertilization (hpf). To measure offspring immune function, larvae at 72 hpf were expose for 24h with/without the viral mimic polyinosinic-cytidylic acid (Poly I:C) or the bacterial mimic Pam3Cys-Ser-Lys4 (PAM3CSK4). Data show modified immunity in offspring. Specifically, lysozyme activity was significantly induced in F1 larvae and respiratory burst response and oxidative defense genes were inhibited. Genes of the innate immune system including Toll-like receptors and their downstream molecules and inflammatory cytokines were significantly down-regulated, whereas matrix metalloproteinases were up-regulated in larvae. In addition, recombination-activating genes in the immature adaptive immune system were significantly reduced. Thus, immune defense is diminished by exposing parental generations of zebrafish to environmentally relevant concentration of bisphenols and this suggests that fish chronically exposed to bisphenols in the wild may be vulnerable to pathogens.

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Section: Discussionmentioning

confidence: 99%

Section: G R a P H I C A L Abstractmentioning

confidence: 99%

Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity

Dong

Zhang

Meng

et al. 2018

Science of The Total Environment

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“…Alternatively, there may be mechanisms that limit immunological activity according to anti-oxidative capacity [57] (i.e., where anti-oxidative potential is low immune responses are curtailed in order to prevent oxidative self-damage). In this latter regard, one possible link to environmental variation might be through selenium intake in the diet, as this element can be present in limiting quantities in nature and is a cofactor for selenoprotein enzymes (including glutathione peroxidases) involved in anti-oxidative physiology [58, 59]. …”

Section: Discussionmentioning

confidence: 99%

Changing expression of vertebrate immunity genes in an anthropogenic environment: a controlled experiment

et al. 2016

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BackgroundThe effect of anthropogenic environments on the function of the vertebrate immune system is a problem of general importance. For example, it relates to the increasing rates of immunologically-based disease in modern human populations and to the desirability of identifying optimal immune function in domesticated animals. Despite this importance, our present understanding is compromised by a deficit of experimental studies that make adequately matched comparisons between wild and captive vertebrates.ResultsWe transferred post-larval fishes (three-spined sticklebacks), collected in the wild, to an anthropogenic (captive) environment. We then monitored, over 11 months, how the systemic expression of immunity genes changed in comparison to cohort-matched wild individuals in the originator population (total n = 299). We found that a range of innate (lyz, defbl2, il1r-like, tbk1) and adaptive (cd8a, igmh) immunity genes were up-regulated in captivity, accompanied by an increase in expression of the antioxidant enzyme, gpx4a. For some genes previously known to show seasonality in the wild, this appeared to be reduced in captive fishes. Captive fishes tended to express immunity genes, including igzh, foxp3b, lyz, defbl2, and il1r-like, more variably. Furthermore, although gene co-expression patterns (analyzed through gene-by-gene correlations and mutual information theory based networks) shared common structure in wild and captive fishes, there was also significant divergence. For one gene in particular, defbl2, high expression was associated with adverse health outcomes in captive fishes.ConclusionTaken together, these results demonstrate widespread regulatory changes in the immune system in captive populations, and that the expression of immunity genes is more constrained in the wild. An increase in constitutive systemic immune activity, such as we observed here, may alter the risk of immunopathology and contribute to variance in health in vertebrate populations exposed to anthropogenic environments.Electronic supplementary materialThe online version of this article (doi:10.1186/s12862-016-0751-8) contains supplementary material, which is available to authorized users.

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“…To neutralize the harmful effects of ROS, fish have developed a complex antioxidant system that includes antioxidant enzymes (Halliwell & Gutteridge, ), minerals and vitamins. Fish species may acquire antioxidant compounds they cannot synthesize, such as selenium (Se) and vitamin E, through their feed (Biller‐Takahashi, Takahashi, Mingatto, & Urbinati, ; Li, Lian, Chen, Wang, & Sang, ). Moreover, coping with chronic stress condition imposes an energy and metabolic cost that may interfere with the needs of the immune function in farmed fish, and therefore, the chances of an disease may be increased (Andrade et al, ; Nardocci et al, ; Tort, ).…”

Section: Introductionmentioning

confidence: 99%

Interactive effects of dietary Nano selenium and vitamin E on growth, haematology, innate immune responses, antioxidant status and muscle composition of rainbow trout under high rearing density

et al. 2019

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A 60‐day feeding trial was conducted to evaluate effects and interactions of dietary Nano selenium (Nano Se) and vitamin E on performance of rainbow trout under high rearing density (80 kg/m3). Fish (42.6 ± 2.3 g) were stocked into 12 tanks: Control group fed basal diet and three treatment groups fed basal diet supplemented with 1 mg/kg Nano selenium (Nano Se group), 500 mg/kg vitamin E (Vit E group) and both micronutrients (Combination group). Results showed that growth, feed intake, lysozyme activity and agglutination antibody titre were significantly higher in Vit E and Combination groups. The lowest haematocrit, haemoglobin and cortisol levels and highest serum total protein and muscle crude protein were observed in Combination group. Serum globulin content was higher and albumin: globulin ratio was lower in treatment groups compared with Control. Also, the highest muscle catalase, superoxide dismutase and glutathione peroxidase activities and lowest malondialdehyde content were observed in Combination group compared with Control. In conclusion, combined supplementation of Nano Se and vitamin E provides a synergistic interaction in preventing the immunosuppressive action of oxidative stress caused by high density and significantly improved antioxidant and immune systems, health status and growth of fish under intensive culture.

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The immune system is limited by oxidative stress: Dietary selenium promotes optimal antioxidative status and greatest immune defense in pacu Piaractus mesopotamicus

Cited by 90 publications

References 53 publications

Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity

Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity

Changing expression of vertebrate immunity genes in an anthropogenic environment: a controlled experiment

Interactive effects of dietary Nano selenium and vitamin E on growth, haematology, innate immune responses, antioxidant status and muscle composition of rainbow trout under high rearing density

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