The immune system of cyprinid fish. Oxytetracycline and the regulation of humoral immunity in carp (Cyprinus carpio)

Rijkers, Ger T.; Oosterom, R.; Muiswinkel, W.B. van

doi:10.1016/0165-2427(81)90029-5

Cited by 90 publications

(58 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of earlier studies (Rijkers et al, 1980;Avtalion, 1981;Bly & Clem, 1992) predict that fish in cooler water would have lower immune responses than those of fish in warmer water. However, APC responses of fish collected in the Willamette River and Dexter Dam did not di#er even though temperatures varied from 11 to 21 C, and APC increased in fish transferred from Dexter Dam to OSU when water temperature was 12 C at both sites.…”

Section: Discussionmentioning

confidence: 89%

Immune and endocrine responses of adult chinook salmon during freshwater immigration and sexual maturation

Maule¹,

Schrock²,

Slater

et al. 1996

Fish & Shellfish Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 89%

Immune and endocrine responses of adult chinook salmon during freshwater immigration and sexual maturation

Maule¹,

Schrock²,

Slater

et al. 1996

Fish & Shellfish Immunology

View full text Add to dashboard Cite

“…Immunomodulating e#ects of OTC have been reported in fish, birds and mammals (Rijkers et al, 1980(Rijkers et al, , 1981Van den Bogert & Kroon, 1982;Siwicki et al, 1989). Rijkers et al (1980Rijkers et al ( , 1981 showed that the peak values of the humoral response were depressed and also the kinetics of the lymphoid cells involved were negatively influenced by OTC in carp.…”

Section: Discussionmentioning

confidence: 95%

Influence of oxytetracycline and oxolinic acid on the immune response of rainbow trout (Oncorhynchus mykiss)

Lundén

Miettinen

Lönnström

et al. 1998

Fish & Shellfish Immunology

View full text Add to dashboard Cite

“…In animals, tetracyclines have been shown to suppress the DTH. the rejection of transplants [8][9][10][11] and levels of serum immunoglobulin [9,12]. Furthermore, in vitro tetracyclines inhibited the proliferative response of human peripheral blood mononuclear cells (PBMC) to mitogens [13][14][15][16].…”

Section: Introdljctionmentioning

confidence: 99%

The influence of tetracyclines on T cell activation

Kloppenburg

Verweij

Miltenburg

et al. 1995

Clinical and Experimental Immunology

106

View full text Add to dashboard Cite

SUMMARYMinocycHne has been shown to have an anti-inflammatory effect in patients with rhetimatoid arthritis (RA). Since there is evidence thai RA is a T cell-mediated disease, we investigated Ihe efl'ect of minocycline on human T cell clones derived from the synovium of an RA patient. The T cells, when activated via the T cell receptor {TCR)/CD3 complex, were suppressed functioniiUy by minocyciine, resulting in a dose-dependent inhibition of T eell proliferation and reduction in production of lL-2. inlerferon-gamma (IFN-7) and tumour necrosis faetor-alpha (TNF-Q). Besides an inhibition of IL-2 production, mitiocycline exerted its effect on T cell proliferation by induction of a decreased IL-2 responsiveness. We showed that the ehelating capacity of minocycline plays a crucial role in the inhibitory effect on T eell function, since the inhibitory elTecl on T cell proliferation could be annulled hy addition of exogenous Ca^^. However, minocycline did nol markedly influence the typical TCR/CD3-induced intracellular Ca^* mobilization. Taken together. Ihe results elearly indicate that minocycline has immunomodulating effects on human T cells.

show abstract

The immune system of cyprinid fish. Oxytetracycline and the regulation of humoral immunity in carp (Cyprinus carpio)

Cited by 90 publications

References 19 publications

Immune and endocrine responses of adult chinook salmon during freshwater immigration and sexual maturation

Immune and endocrine responses of adult chinook salmon during freshwater immigration and sexual maturation

Influence of oxytetracycline and oxolinic acid on the immune response of rainbow trout (Oncorhynchus mykiss)

The influence of tetracyclines on T cell activation

Contact Info

Product

Resources

About