The Immunologic and Genetic Basis of Psoriasis

Nickoloff, Brian J.

doi:10.1001/archderm.135.9.1104

Cited by 175 publications

(166 citation statements)

References 71 publications

(58 reference statements)

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“…In psoriasis, IL-6 enhances activation, proliferation and chemotaxis of T cells into psoriatic lesions (8). It is also a direct keratinocyte mitogen that could directly stimulate keratinocyte proliferation.…”

Section: Discussionmentioning

confidence: 99%

Possible association of psoriasis and reduced bone mineral density due to increased TNF-α and IL-6 concentrations

Kaštelan

Massari

et al. 2006

Medical Hypotheses

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Section: Discussionmentioning

confidence: 99%

Possible association of psoriasis and reduced bone mineral density due to increased TNF-α and IL-6 concentrations

Kaštelan

Massari

et al. 2006

Medical Hypotheses

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“…Son yirmi yıl içinde patogenezde T hücrelerinin anahtar rolü olduğu açıkça anlaşılmıştır. Günümüzde keratinosit proliferasyonunun sekonder biyolojik bir fenomen olduğu, asıl rolü kesin olarak tanımlanmamış antijenik uyarana karşı deriye infiltre olan T hücrelerinden salınan Interferon-gama (IFN-γ), tümör nekrozis faktör-α (TNF-α), IL (interlökin)-1, IL-2, IL-6, IL-8 ve IL-12 gibi çok sayıda proinflamatuvar sitokinin oynadığı kabul edilmektedir [1][2][3][4] . Neopterin, hücresel immün sistemin özgül olmayan bir belirleyicisi olarak kabul edilen pteridin ailesine mensup bir sitokindir 5 .…”

Section: Gi Riflunclassified

Psoriasisde Serum Neopterin ve TNF-α Düzeyleri ve Hastalık Şiddeti ile İlişkisi

Ceyhan¹,

Yıldırım²,

Ceyhan³

et al. 2012

Turkderm

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ÖzetAmaç: Psoriasis, henüz tam olarak tanımlanamamış bir antijenik uyarana yanıt olarak artmış keratinosit proliferasyonu ve aktive olmuş T hücre birikimi ile karakterize T hücre aracılı otoimmün bir deri hastalığıdır. Psoriatik lezyonun oluşumunda ve devamında tümör nekrozis faktör-α (TNF-α) oldukça önemli rol oynamaktadır. Neopterin hücresel immün aktivasyonun spesifik olmayan immünolojik belirteci olup; T lenfositlerden salınan interferon gama'nın oluşturduğu uyarıya yanıt olarak insan monosit ve makrofajlarında üretilmektedir. Bu çalışmada, psoriasisli hastalarda serum neopterin ve TNF-α düzeylerini araştırmayı ve PASI (Psoriasis Area and Severity Index) ile aralarında korelasyon olup olmadığını değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmaya 40 psoriasisli hasta ve 37 sağlıklı birey dahil edildi. Tüm bireylerde serum neopterin ve TNF-α düzeyleri Enzyme Immunoassay (ELİSA) yöntemi ile ölçüldü. Psoriasisli hastalarda PASI skorlaması yapıldı ve serum neopterin ve TNF-α düzeyleri ile PASI skoru arasında korelasyon araştırıldı. Bulgular: Psoriasisli hastalarda ortalama serum neopterin düzeyleri kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı şekilde yüksek idi (sırasıyla 11,04±5,42 nmol/L ve 5,44±2,40 nmol/L, p<0,001). Ortalama serum TNF-α konsantrasyonları da psoriasisli hastalarda (8,51±2,34) kontrol grubuna (7,09±1,77 pg/ml) kıyasla anlamlı olarak yüksek saptandı (p=0,013). Fakat serum neopterin ve TNF-α düzeyleri ile PASI skoru arasında anlamlı korelasyon yok idi (p>0,05 sırası ile r=-0,096 ve r=0,089). Serum neopterin düzeyleri ile serum TNF-α düzeyleri arasında da anlamlı bir korelasyon saptanmadı (p>0,05, r=0,214). Sonuç: Çalışmanın sonuçları serum neopterin ve TNF-α düzeylerinin psoriasisde hastalık şiddetini yansıtması açısından güvenilir bir laboratuvar belirteci olarak kullanılamayacağını göstermektedir. (Türk derm 2012; 46: 7-10) Anah tar Ke li me ler: Psoriasis, neopterin, TNF-α Sum maryBackground and Design: Psoriasis is a T cell-mediated autoimmune skin disease characterized by hyperproliferation of keratinocytes and accumulation of activated T cells responding to a hitherto unidentified antigenic stimulus. Tumor necrosis factor-α (TNF-α) plays an essential role in the induction and maintenance of psoriatic lesion. Neopterin is a non-specific immunological marker of cellular immune activation, which is produced by human monocytes/macrophages as a result of interferon-gamma secretion by activated T lymphocytes. The aim of the presented study was to determine the levels of serum neopterin and TNF-α in psoriatic patients and to evaluate whether Psoriasis Area correlated with Severity Index (PASI) and serum levels of neopterin and TNF-α. Materials and Methods: Forty patients with psoriasis and thirty-seven healthy controls were included in this study. Serum neopterin and TNF-α levels in all subjects were measured by the Enzyme Immunoassay (ELISA) method. The disease severity index was assessed in psoriatic patients by means of PASI and correlation of PASI scores with serum le...

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“…Only very recently, the possible crucial involvement of components of the innate immune systems including natural killer characteristics of T cells has been brought to the awareness of the scientific community. 4,5,14 Moreover, the obvious clinical diver-sity of psoriasis and its variants lends support to the notion that heterogeneic pathomechanism may co-exist, as well as combinations thereof.…”

mentioning

confidence: 93%

“…[1][2][3][4][5][6][7] But there is a lot of at least indirect clinical and experimental evidence that speaks in favor of a predominantly immunological quality of its pathogenesis. Nowadays, autoantigen-directed mechanisms intermingled with microbial (super)-antigen-driven immune-activations are hypothesized to play major roles in psoriasis, with the primary relevance of T-cell actions prevailing over antibody-mediated processes.…”

mentioning

confidence: 99%

Suprabasal Overexpression of the hsRPB7 Gene in Psoriatic Epidermis as Identified by a Reverse Transcriptase-Polymerase Chain Reaction Differential Display Model Comparing Psoriasis Plaque Tissue with Peritonsillar Mucosa

Böckelmann

Neugebauer

Paseban

et al. 2001

The American Journal of Pathology

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In psoriasis an etiopathogenetic vicious circle is nowadays hypothesized that the disease is triggered by skin-specific autoantigen structures, the expression and accessibility of which are positively correlated with the intensity of the hyperproliferation and inflammation in the epidermopapillary compartment driven by autoreactive T cells. Despite the close microanatomical relation between skin and mucosa, clinicians have always been intrigued by the observation that psoriatic affection of the mucosa, if at all existing, is only seen as very rare events in the lips and tongue sparing buccopharyngeal sites. This prompted us to establish an experimental model system comparing psoriatic-involved skin and peritonsillar mucosa from tonsillectomies by a reverse transcriptase-polymerase chain reaction/differential display strategy. Among more than 60 cDNA species to be displayed in psoriasis, but missing in peritonsillar mucosa, one species was identified as coding for the RNA polymerase IIA seventh subunit (hsRPB7 gene) as a most critical factor for DNA to RNA transcription. Immunohistochemistry showed a hitherto unknown, distinctive pattern of hsRPB7 expression that was 1) tissue type-dependent with a surplus in skin keratinocytes and a near absence in peritonsillar mucosa, 2) tightly regulated by the keratinocyte differentiation process with a sharp suprabasal up-regulation in contrast to a basal down-regulation, and 3) substantially augmented in psoriatic-involved skin as compared to normal and psoriatic uninvolved skin. Keratinocytes of actinic keratoses also showed a strong hsRPB7 expression that however did not strictly spare the basal cell layer presumably reflecting the disturbed intraepidermal stratification because of the premalignant status of these precancerous lesions. The etiology of psoriasis is still unknown.

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The Immunologic and Genetic Basis of Psoriasis

Cited by 175 publications

References 71 publications

Possible association of psoriasis and reduced bone mineral density due to increased TNF-α and IL-6 concentrations

Possible association of psoriasis and reduced bone mineral density due to increased TNF-α and IL-6 concentrations

Psoriasisde Serum Neopterin ve TNF-α Düzeyleri ve Hastalık Şiddeti ile İlişkisi

Suprabasal Overexpression of the hsRPB7 Gene in Psoriatic Epidermis as Identified by a Reverse Transcriptase-Polymerase Chain Reaction Differential Display Model Comparing Psoriasis Plaque Tissue with Peritonsillar Mucosa

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