The impact of chemotherapeutic treatment on the oral microbiota of patients with cancer: a systematic review

Villafuerte, Kelly Rocio Vargas; Martinez, Cristhiam de Jesus Hernandez; Dantas, Felipe Torres; Carrara, Hélio Humberto Angotti; Reis, Francisco José Cândido dos; Palioto, Daniela Bazan

doi:10.1016/j.oooo.2018.02.008

Cited by 28 publications

(21 citation statements)

References 49 publications

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“…However, this association was only reported in patients treated with surgery and chemoradiation as compared to patients treated with just surgical removal of the tumor and to healthy controls. This suggests that chemoradiation might cause the increased relative abundance of these bacteria, which is in line with the known presence of a more complex oral microbiota in cancer patients treated with chemotherapy [70]. The relative abundance of the genus Capnocytophaga was found decreased in saliva samples of healthy controls in an OSCC study [63].…”

Section: Streptococcussupporting

confidence: 54%

“…In some cases, such as the study by Olson et al [76], the selection criteria were so strict that from 281 approached patients, 80% were considered ineligible for various reasons, most importantly because they had been previously treated with chemotherapy. The previous history of treatment with neo-adjuvant chemotherapy or chemoradiation influences substantially the microbiome profile [70]. Therefore, all the criteria followed for the selection of patients and control subjects should be well-documented and taken into account when performing the statistical analyses of results.…”

Section: Phc Gac Crcmentioning

confidence: 99%

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Oral Microbiota Associated with Oral and Gastroenteric Cancer

Robayo¹,

Hernandez²,

Erira³

et al. 2020

TOMICROJ

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When the normal microbiota-host interactions are altered, the commensal microbial community evolves to a dysbiotic status resulting in some species becoming pathogenic and acting synergistically in the development of local and systemic diseases, including cancer. Advances in genetics, immunology and microbiology during the last years have made it possible to gather information on the oral and gastrointestinal microbiome and its interaction with the host, which has led to a better understanding of the interrelationship between microbiota and cancer. There is growing evidence in support for the role of some species in the development, progression and responses to treatment of various types of cancer. Accordingly, the number of studies investigating the association between oral microbiota and oral and gastrointestinal cancers has increased significantly during the last years. Here, we review the literature documenting associations of oral microbiota with oral and gastroenteric cancers.

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Section: Streptococcussupporting

confidence: 54%

Section: Phc Gac Crcmentioning

confidence: 99%

Oral Microbiota Associated with Oral and Gastroenteric Cancer

Robayo¹,

Hernandez²,

Erira³

et al. 2020

TOMICROJ

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“…A chemotherapy-induced increase in oral commensal bacterial burdens, particularly aciduric bacteria such as Lactobacilli and Streptococci has also been reported in a chemotherapy treated breast cancer cohort [42]. Moreover, a recent systematic review focusing on evaluation of the impact of chemotherapeutic treatment on the oral microbiota in patients with cancer showed that during chemotherapy, there is an increase in bacteria of the Enterobacteriaceae family and in Streptococcus species, potentially contributing to local oral manifestations, such as oral mucositis, or even systemic infections such as septicemia [43]. Finally, HIV infection was recently associated with lower richness and diversity estimates in the oral bacterial microbiome, with several taxa having increased abundance in this host background.…”

Section: Immunocompomised Hosts Have Altered Oral Bacterial Microbiommentioning

confidence: 87%

The Dysbiosis and Inter-Kingdom Synergy Model in Oropharyngeal Candidiasis, a New Perspective in Pathogenesis

Bertolini

Dongari-Bagtzoglou

2019

JoF

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As more information emerges on oral microbiota using advanced sequencing methodologies, it is imperative to examine how organisms modulate the capacity of each other to colonize or trigger infection. Most mouse models of oral C. albicans infection have focused on interactions with single bacterial species. Thus, little is known about the microbiome-mediated interactions that control the switch of C. albicans from commensalism to infection. Evidence is accumulating that in immunosuppression where mucosal candidiasis is more prevalent, there is an altered oral bacterial microbiome with reduced diversity, but not an altered mycobiome. Oropharyngeal candidiasis in immunosuppressed humans and mice is associated with a further reduction in oral bacterial diversity and a dysbiotic shift with significant enrichment of streptococcal and enterococcal species. Our recent studies in a cancer chemotherapy mouse model supported the combined profound effect of immunosuppression and C. albicans in reducing oral bacterial diversity and provided the first direct evidence that these changes contribute to pathogenesis, representing dysbiosis. There is still a gap in understanding the relationship between Candida and the oral bacterial microbiome. We propose that certain oral commensal bacteria contribute to fungal pathogenesis and we identify gaps in our understanding of the mechanisms involved in this cooperative virulence.

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“…Klebsiella spp. is the main bacterium in the oral flora during the immunosuppression of cancer patients, which may lead to severe local or systemic disease in these patients (114). We believe that the changes in the intestinal flora of patients with sporadic NPC can lead to the disruption of the immune function by promoting inflammation that triggers cancer and may also affect the liver function.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Flora Disruption and Novel Biomarkers Associated With Nasopharyngeal Carcinoma

Jiang

Zhang

et al. 2019

Front. Oncol.

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Background: Nasopharyngeal carcinoma (NPC) is a malignant nasopharyngeal disease with a complicated etiology that occurs mostly in southern China. Intestinal flora imbalance is believed to be associated with a variety of organ malignancies. Current studies revealed that the destruction of intestinal flora is associated with NPC, and many studies have shown that intestinal flora can be used as a biomarker for many cancers and to predict cancer.Methods: To compare the differences in intestinal flora compositions and biological functions among 8 patients with familial NPC (NPC_F), 24 patients with sporadic NPC (NPC_S), and 27 healthy controls (NOR), we compared the intestinal flora DNA sequencing and hematological testing results between every two groups using bioinformatic methods.Results: Compared to the NOR group, the intestinal flora structures of the patients in the NPC_F and NPC_S groups showed significant changes. In NPC_F, Clostridium ramosum, Citrobacter spp., Veillonella spp., and Prevotella spp. were significantly increased, and Akkermansia muciniphila and Roseburia spp. were significantly reduced. In NPC_S, C. ramosum, Veillonella parvula, Veillonella dispar, and Klebsiella spp. were significantly increased, and Bifidobacterium adolescentis was significantly reduced. A beta diversity analysis showed significant difference compared NPC_F with NOR based on Bray Curtis (P = 0.012) and Unweighted UniFrac (P = 0.0045) index, respectively. The areas under the ROC curves plotted were all 1. Additionally, the concentrations of 5-hydroxytryptamine (5-HT) in NPC_F and NPC_S were significantly higher than those of NOR. C. ramosum was positively correlated with 5-HT (rcm: 0.85, P < 0.001). A functional analysis of the intestinal flora showed that NPC_F was associated with Neurodegenerative Diseases (P = 0.023) and that NPC_S was associated with Neurodegenerative Diseases (P = 0.045) as well.Conclusion: We found that NPC was associated with structural imbalances in the intestinal flora, with C. ramosum that promoted the elevation of 5-HT and opportunistic pathogens being significantly increased, while probiotics significantly decreased. C. ramosum can be used as a novel biomarker and disease prediction models should be established for NPC. The new biomarkers and disease prediction models may be used for disease risk prediction and the screening of high-risk populations, as well as for the early noninvasive diagnosis of NPC.

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The impact of chemotherapeutic treatment on the oral microbiota of patients with cancer: a systematic review

Abstract: During chemotherapy, patients with cancer present a more complex oral microbiota under favorable conditions for their development during immunosuppression, and these may be responsible for different serious local or systemic pathologies.

Cited by 28 publications

References 49 publications

Oral Microbiota Associated with Oral and Gastroenteric Cancer

Oral Microbiota Associated with Oral and Gastroenteric Cancer

The Dysbiosis and Inter-Kingdom Synergy Model in Oropharyngeal Candidiasis, a New Perspective in Pathogenesis

Intestinal Flora Disruption and Novel Biomarkers Associated With Nasopharyngeal Carcinoma

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