The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians

Cyrus, Cyril; Vatte, Chittibabu; Al-Nafie, Awatif; Chathoth, Shahanas; Alali, Rudaynah A; Alshehri, Abdullah; Akhtar, Mohammed; Almansori, Mohammed; Al-Muhanna, Fahad; Keating, Brendan J.; Al-Ali, Amein K.

doi:10.1186/s40246-016-0065-3

Cited by 21 publications

(20 citation statements)

References 46 publications

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“…Lp(a) has been reported to be an independent risk factor for CAD in Asians44 and Caucasians 45. In agreement with our finding, Cyrus et al 46 also reported an increased risk of CAD in A allele carriers of the rs2230806 polymorphism.…”

Section: Discussionsupporting

confidence: 92%

Effects of ABCA1 gene polymorphisms on risk factors, susceptibility and severity of coronary artery disease

Wang

Jia

et al. 2020

Postgraduate Medical Journal

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BackgroundThe relationships between the rs1800976, rs4149313 and rs2230806 polymorphisms in ATP binding cassette protein A1 and severity of coronary artery disease (CAD) remain unclear.MethodsFour hundred and forty-two patients with CAD and 217 CAD-free subjects were enrolled in this study. The rs1800976, rs4149313 and rs2230806 polymorphisms were genotyped by PCR-RFLP. Severity of CAD was evaluated by Gensini score system, number of stenotic coronary vessels and extent of coronary stenosis.ResultsC allele of the rs1800976 polymorphism, G allele of the rs4149313 polymorphism and A allele of the rs2230806 polymorphism were found to be risk alleles for CAD (p<0.05 for all). In patients with CAD, C allele of the rs1800976 polymorphism was associated with high levels of hypersensitive C reactive protein (hs-CRP) and cystatin c (CysC), and its frequency increased with percentiles of Gensini score, number of stenotic coronary vessels and extent of coronary stenosis (p<0.05 for all). The subjects with GA genotype of the rs4149313 polymorphism had higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B and hs-CRP than those with AA genotype (p<0.05 for all). The subjects with AA genotype of the rs2230806 polymorphism had higher levels of TC, LDL-C and uric acid than those with GA genotype (p<0.05 for all). No associations between the rs4149313 or rs2230806 polymorphism and severity of CAD were detected.ConclusionsThe rs1800976 polymorphism is significantly associated with the occurrence and severity of CAD, which is possibly mediated by hs-CRP and CysC.

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Section: Discussionsupporting

confidence: 92%

Effects of ABCA1 gene polymorphisms on risk factors, susceptibility and severity of coronary artery disease

Wang

Jia

et al. 2020

Postgraduate Medical Journal

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“…The study selection process is detailed in Figure 1 . Through a comprehensive retrieval and evaluation, 45 studies from 44 papers with 20,866 cases and 21,298 controls met the inclusion criteria to assess the association between the CETP TaqIB polymorphism and the composite ischemic CVD [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. The selected study characteristics and data are listed in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

Guo

Yao

Ding

et al. 2016

IJERPH

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Background: Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods: We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results: Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions: The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

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“…The data on a number of world populations show that carriers of the G allele of the CETP polymorphic locus (G1264A, rs5882) reduce transfer protein activity and therefore increase HDL (Thompson et al, 2008) as well as decreased triglycerides compared to АА homozygotes (HosseiniEsfahani et al, 2019). In a number of studies, inverse associations of the 1264G allele increasing a risk of atherosclerosis have been found (Thompson et al, 2008;Cyrus et al, 2016). A twin study of European population showed that GG homozygotes have lower body mass index, fat mass, and subcutaneous fat thickness, while АА homozygotes demonstrated a faster weight gain under overnutrition (Teran-Garcıa et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of lipid exchange genes in some populations of South and East Siberia

et al. 2020

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Lipid metabolism disorders underlie the pathogenesis of a number of diseases. Indigenous peoples of Siberia have a specific genetically determined type of metabolism supporting such lipid blood parameters that favor increased consumption (in comparison with Caucasians) of animal products. At the same time, indigenous Siberian ethnic groups are less susceptible to metabolic diseases. The objective of the presented study was to investigate the allele frequencies of lipid metabolism genes in indigenous populations of Siberia to identify the ethnic features of allele frequency distribution for polymorphic variants in genes CETP (G1264A, rs5882), LPL (C1791G, rs328) and FTO (C83401A, rs8050136) in the samples taken from Buryats, Teleuts and Russians of Eastern Siberia, and to compare them with data on world populations. Samples of the Eastern (N = 132) and Western (N = 278) Buryats, Teleuts (N = 120), Russians (N = 122) and persons of mixed Buryat-Russian origin (N = 56) were genotyped by real-time PCR using competitive TaqMan-probes. The obtained results have for the first time demonstrated that the CETP and FTO allele frequencies in the Buryat samples are intermediate between European and East Asian populations. Significantly lower incidence of the obesity-assossiated 83401A allele of the FTO gene has been shown in Buryats, compared with Russians, which is consistent with lower susceptibility of the indigenous ethnic groups to metabolic disorders. There have been no population differences in the distribution of LPL gene polymorphic variants associated with dyslipidemia, which means they probably do not contribute to the ethnic characteristics of the lipid profile. The intermediate frequencies of the CETP 1264G and FTO 83401A alleles found in the metis group demonstrate that the metabolic disorders associated with these variants can be rather expected in the descendants of mixed marriages than among Buryats. It has also been demonstrated that Teleuts differ by FTO 83401A allele frequency from some of the European groups and have the lowest detected frequency of the allele CETP 1264G associated with the favorable lipid blood parameters.

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The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians

Cited by 21 publications

References 46 publications

Effects of ABCA1 gene polymorphisms on risk factors, susceptibility and severity of coronary artery disease

Effects of ABCA1 gene polymorphisms on risk factors, susceptibility and severity of coronary artery disease

Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

Polymorphism of lipid exchange genes in some populations of South and East Siberia

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