The Impact of Donor Type on Long-Term Health Status and Quality of Life after Allogeneic Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Leucémie de l'Enfant et de L'Adolescent Study

Visentin, Sandrine; Auquier, Pascal; Bertrand, Yves; Baruchel, André; Tabone, Marie‐Dominique; Pochon, Cécile; Jubert, Charlotte; Poirée, Maryline; Gandemer, Virginie; Sîrvent, Anne; Bonneau, Jacinthe; Paillard, Catherine; Freyçon, Claire; Kanold, Justyna; Villes, Virginie; Berbis, Julie; Oudin, Claire; Garrigue, Claire; Pellier, Isabelle; Plat, Geneviève; Chambost, Hérvè; Leverger, Guy; Dalle, Jean‐Hugues; Gautier, Michel

doi:10.1016/j.bbmt.2016.08.004

Cited by 15 publications

(27 citation statements)

References 40 publications

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“…162 One study showed that the risk of AVN was elevated after cord blood transplantation, but graft source had a limited influence on other long-term health status and QOL. 163 …”

Section: Introductionmentioning

confidence: 99%

Late effects of blood and marrow transplantation

Inamoto¹,

2017

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Hematopoietic cell transplantation is a curative treatment for a variety of hematologic diseases. Advances in transplantation technology have reduced early transplant-related mortality and expanded application of transplantation to older patients and to a wider variety of diseases. Management of late effects after transplantation is increasingly important for a growing number of long-term survivors that is estimated to be half a million worldwide. Many studies have shown that transplant survivors suffer from significant late effects that adversely affect morbidity, mortality, working status and quality of life. Late effects include diseases of the cardiovascular, pulmonary, and endocrine systems, dysfunction of the thyroid gland, gonads, liver and kidneys, infertility, iron overload, bone diseases, infection, solid cancer, and neuropsychological effects. The leading causes of late mortality include recurrent malignancy, lung diseases, infection, secondary cancers and chronic graft-versus-host disease. The aim of this review is to facilitate better care of adult transplant survivors by summarizing accumulated evidence, new insights, and practical information about individual late effects. Further research is needed to understand the biology of late effects allowing better prevention and treatment strategies to be developed.

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“…162 One study showed that the risk of AVN was elevated after cord blood transplantation, but graft source had a limited influence on other long-term health status and QOL. 163 …”

Section: Introductionmentioning

confidence: 99%

Late effects of blood and marrow transplantation

Inamoto¹,

2017

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“…A few studies that have investigated quality of life show inconsistent results. A Swedish (Lof, Winiarski, Giesecke, Ljungman, & Forinder, 2009) and a French (Visentin et al, 2016) study report a poorer quality of life for almost all dimensions among adult long-term survivors who had undergone allo-SCT during childhood, while a Danish study showed similar levels of quality of life compared to the general population (Jensen et al, 2016).…”

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confidence: 99%

“…Additionally, reviews report that these paediatric patients are at a high risk of psychological distress such as anxiety and depression and lower social well-being, which can have a negative impact on quality of life both during and a long time after the allo-SCT (Tanzi, 2011;Visentin et al, 2016). Additionally, reviews report that these paediatric patients are at a high risk of psychological distress such as anxiety and depression and lower social well-being, which can have a negative impact on quality of life both during and a long time after the allo-SCT (Tanzi, 2011;Visentin et al, 2016).…”

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confidence: 99%

“…Additionally, reviews report that these paediatric patients are at a high risk of psychological distress such as anxiety and depression and lower social well-being, which can have a negative impact on quality of life both during and a long time after the allo-SCT (Tanzi, 2011;Visentin et al, 2016). A Swedish (Lof, Winiarski, Giesecke, Ljungman, & Forinder, 2009) and a French (Visentin et al, 2016) study report a poorer quality of life for almost all dimensions among adult long-term survivors who had undergone allo-SCT during childhood, while a Danish study showed similar levels of quality of life compared to the general population (Jensen et al, 2016). A few studies that have investigated quality of life show inconsistent results.…”

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confidence: 99%

“…). Additionally, reviews report that these paediatric patients are at a high risk of psychological distress such as anxiety and depression and lower social well-being, which can have a negative impact on quality of life both during and a long time after the allo-SCT (Tanzi, 2011;Visentin et al, 2016). The treatment's impact on cognitive function is unclear (Baker, Bresters, & Sande, 2010;Tanzi, 2011), but one study has indicated that only those receiving total body radiation demonstrate a lower level of cognitive functioning (Willard, Leung, Huang, Zhang, & Phipps, 2014).…”

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confidence: 99%

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Occupational status among adult survivors following allogeneic stem cell transplantation in childhood

et al. 2018

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This study examined occupational status and factors associated with sick leave and disability pension among adult long-term survivors previously treated with allogeneic stem cell transplantation (allo-SCT) during childhood. Moreover, occupational status was compared to that of a reference group. Data were collected with questionnaires and from medical records. The SCT group included 59 adults (18-45 years old: response rate 63%) treated with allo-SCT in childhood with a median of 17 (range 3-28) years earlier. The reference group included 296 individuals randomly selected from the general population. The results show that 54% of the long-term survivors were working part- or full-time and that 19% were on sick leave or disability pension. A larger proportion of the SCT group was on sick leave or disability pension (19% vs. 6%: p < .001) than of the reference group. The logistic regression analysis revealed that being on sick leave or disability pension among long-term survivors was associated with late effects related to the allo-SCT (OR 12.28: 95% CI 1.3-111.6: p = .03). The results underscore that long-term survivors' engagement in paid work is influenced many years after treatment and highlights the need to include vocational assistance in the rehabilitation following allo-SCT in childhood.

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Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Larsen

Amidi

Ghith

et al. 2023

Intl Journal of Cancer

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Advances in diagnostics and treatment of childhood cancer during the past few decades have substantially increased survival, resulting in a growing population of survivors of childhood cancer. Somatic and mental late effects of the cancer and the treatment may impact the quality of life (QoL). Previous reviews of QoL in survivors of childhood cancer have shown contradictory findings across studies and the majority of studies included have been based on data from North America and may not be directly comparable to a European setting. The aim of our study was to critically evaluate and summarise the latest evidence on the QoL of childhood cancer survivors in Europe and to identify survivors at particular risk. The eligible studies were published between 2008 and 2022, conducted in Europe and included participants who had survived at least 5 years after diagnosis of a childhood cancer. The main outcome of interest was QoL of survivors which was measured with validated qualitative and quantitative QoL questionnaires. A systematic literature search conducted in PubMed, EMBASE, PsycINFO and CINALH resulted in inclusion of 36 articles with a total of 14 342 survivors of childhood cancer. The majority of included studies found that childhood cancer survivors reported poorer QoL than comparisons. Female gender, treatment with haematopoietic stem cell transplantation and a brain tumour diagnosis were associated with lower QoL. With a growing population of childhood cancer survivors with many years ahead of them, targeted interventions and optimal follow‐up care are important to improve the QoL of survivors.

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The Impact of Donor Type on Long-Term Health Status and Quality of Life after Allogeneic Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Leucémie de l'Enfant et de L'Adolescent Study

Cited by 15 publications

References 40 publications

Late effects of blood and marrow transplantation

Late effects of blood and marrow transplantation

Occupational status among adult survivors following allogeneic stem cell transplantation in childhood

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

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