The impact of ischemic preconditioning on hemodynamic, biochemical and inflammatory alterations induced by intra-abdominal hypertension: an experimental study in a porcine model

Avraamidou, Alexandra; Marinis, Athanasios; Asonitis, Spyridon; Περρέα, Δέσποινα; Polymeneas, G.; Voros, Dionysios; Αrgyra, Eriphili

doi:10.1007/s00423-012-0977-x

Cited by 16 publications

(10 citation statements)

References 40 publications

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“…Similar are the observations of Avraamidou et al, who reported increased urea and creatine serum levels in porcine model of IAP (30 mmHg maintained for 3 h). 16 Pancreatic amylase was not as sensitive as lipase and amylase activity was signifi cantly higher only in the group D exposed to 30 mmHg for 60 min. Interestingly, the values for some biochemical parameters (urea, lipase) found for group C (30 mm Hg/45 min) did not differ from those of the control group.…”

Section: Discussionmentioning

confidence: 87%

Biochemical Changes in Experimental Rat Model of Abdominal Compartment Syndrome

et al. 2017

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Background: Increased intra-abdominal pressure (IAP) causes tissue ischemia, subsequent hypoxia, and impairment of normal tissue metabolism. Elevation of IAP above 20 mmHg leads to progression of abdominal compartment syndrome (ACS) that is associated with organ dysfunction or failure not previously manifested. Aim: To evaluate the eff ects of diff erent grades and time of exposure to IAP on biochemical parameters and oxidative stress in organs aff ected by ischemia using previously developed rat model. Results: Three experimental groups exposed to diff erent IAP and time frames were tested for liver, kidney, and pancreas injury by measuring the activities of tissue specifi c enzymes in blood serum. Elevated activities of aspartate aminotransferase, pancreatic amylase, lipase, and higher concentrations of D-lactate, urea, and creatinine were found in some of the experimental groups compared to a control group of animals not subjected to increased IAP. Increased levels of biomarkers of oxidative stress as well as decrease in concentration of the major cellular antioxidant glutathione indicated the presence of oxidative injury as a result of elevated IAP. Conclusions: The developed rat model is appropriate to study the mechanism and manifestation of tissue injury during diff erent grades of elevated IAP but also to test approaches aimed to attenuate the detrimental eff ects of ACS. This study also underlines the necessity of using not a single but a set of biochemical parameters in order to assess the severity of tissue injury during elevated IAP and progression to ACS. BACKGROUND

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Section: Discussionmentioning

confidence: 87%

Biochemical Changes in Experimental Rat Model of Abdominal Compartment Syndrome

et al. 2017

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“…In a study it was shown that a 12-mm Hg pneumoperitoneum reduces both hepatic and gastric microcirculation and can cause splenic ischaemia [25]. Several studies have shown that liver function tests after LC are elevated and this may be due to hepatic hypoperfusion and ischaemia [26].…”

Section: Discussionmentioning

confidence: 99%

Relationship between clinical and histopathological features of patients undergoing cholecystectomy

Akbulut

Yağmur

Sakarya

et al. 2020

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Introduction: Cholelithiasis is most common disease of the gallbladder and cholecystectomy is the one of the most performed surgical procedure worldwide. Aim: To assess the relationship between the demographic, biochemical, and histopathological variables of patients who underwent cholecystectomy. Material and methods: Demographic, biochemical, and histopathological data of 5077 patients undergoing cholecystectomy were compared in terms of two different aspects: open cholecystectomy (OC group; n = 2090) versus laparoscopic cholecystectomy (LC group; n = 2987), and an elective group (n = 4814) versus an emergency group (n = 263). Results: A total of 5077 patients aged between 13 and 97 years were included in the study. Aspartate aminotransferase (AST) levels, alanine aminotransferase (ALT) levels, mean platelet volume, and prevalence of acute/chronic cholecystitis were significantly higher in the LC group than in the OC group. On the other hand, age, direct bilirubin level, thrombocyte count, and prevalence of gallbladder cancer/gangrenous cholecystitis were significantly higher in the OC group than in the LC group. Levels of AST, ALT, white blood cells, neutrophils, and some prevalence of acute/chronic active cholecystitis were higher in the emergency group than in the elective group. On the other hand, the lymphocyte count and prevalence of chronic cholecystitis/hyperplastic polyps were higher in the elective group than in the emergency group. Histopathological analysis identified 32 patients with malignant gallbladder cancer as follows: adenocarcinoma (n = 21), mucinous adenocarcinoma (n = 3), papillary adenocarcinoma (n = 3), adenosquamous carcinoma (n = 1), clear cell adenocarcinoma (n = 2), squamous carcinoma (n = 1), and hepatocellular carcinoma metastasis (n = 1). Conclusions: Even when the appearance of gallbladder specimens is normal, histopathological assessment allows for early diagnosis of many unusual findings such as gallbladder cancer.

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“…CRP, a biomarker of produced inflammatory response, seems to be affected in experimental models of RIPC. Avraamidou et al [47] found that CRP levels were attenuated after the application of ischemic preconditioning in a swine model of intra-abdominal hypertension. Similarly, in a rat model of myocardial infarction, myocardial CRP levels were significantly elevated in the nonpreconditioned IRI animals [48].…”

Section: Discussionmentioning

confidence: 99%

Remote Ischemic Preconditioning May Attenuate Renal Ischemia-Reperfusion Injury in a Porcine Model of Supraceliac Aortic Cross-Clamping

Athanasiadis

Kapelouzou²,

Martikos³

et al. 2015

J Vasc Res

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Aim: The effect of remote ischemic preconditioning (RIPC) in decreasing renal ischemia-reperfusion injury (IRI) during a suprarenal aortic cross-clamping was examined in a swine model. Materials and Methods: Four groups of pigs were examined: (a) ischemia-reperfusion (IR) group, renal IRI produced by 30 min of supraceliac aortic cross-clamping; (b) RIPC I group, the same renal IRI following RIPC by brief occlusion of the infrarenal aorta (15 min ischemia and 15 min reperfusion); (c) RIPC II group, the same renal IRI following RIPC by brief occlusion of the infrarenal aorta (3 cycles of 5 min ischemia and 5 min reperfusion); (d) sham group. Renal function was assessed before and after IRI by examining creatinine, neutrophil gelatinase-associated lipocalin (NGAL), TNF-α, malondialdehyde (MDA), cystatin C and C-reactive protein (CRP) from renal vein blood samples at specific time intervals. Results: Both RIPC groups presented significantly less impaired results compared to the IR group when considering MDA, cystatin C, CRP and creatinine. Between the two RIPC groups, RIPC II presented a better response with regard to CRP, NGAL, TNF-α, MDA and cystatin C. Conclusions: Remote IR protocols and mainly repetitive short periods of cycles of IR ameliorate the biochemical kidney effects of IRI in a model of suprarenal aortic aneurysm repair.

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The impact of ischemic preconditioning on hemodynamic, biochemical and inflammatory alterations induced by intra-abdominal hypertension: an experimental study in a porcine model

Abstract: Ischemic preconditioning seems to attenuate the pathophysiologic alterations of several hemodynamic, biochemical and inflammatory parameters observed during IAH.

Cited by 16 publications

References 40 publications

Biochemical Changes in Experimental Rat Model of Abdominal Compartment Syndrome

Biochemical Changes in Experimental Rat Model of Abdominal Compartment Syndrome

Relationship between clinical and histopathological features of patients undergoing cholecystectomy

Remote Ischemic Preconditioning May Attenuate Renal Ischemia-Reperfusion Injury in a Porcine Model of Supraceliac Aortic Cross-Clamping

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