The impact of lymphovascular invasion in patients with prostate cancer following radical prostatectomy and its association with their clinicopathological features

Jiang, Wei; Zhang, Lijin; Wu, Bin; Zha, Zhenlei; Hu, Zhao; Jiang, Yuefang

doi:10.1097/md.0000000000013537

Cited by 24 publications

(27 citation statements)

References 41 publications

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“…Recently, mounting evidence has indicated that LVI is associated with poor prognosis for many types of tumors, such as liver, bladder, and prostate cancer (7,44). Jiang et al (6) reported that LVI is an independent prognostic factor for predicting worse progression in prostate cancer, and they recommended that LVI should be reported in the final pathological diagnosis after radical prostatectomy. Similarly, Canter et al (45) found that the presence of LVI in the final pathological reports for bladder cancer delivers significant risks for worse CSS and OS.…”

Section: Discussionmentioning

confidence: 99%

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The Prognostic Value of Lymphovascular Invasion in Patients With Upper Tract Urinary Carcinoma After Surgery: An Updated Systematic Review and Meta-Analysis

Zhang

Zha

et al. 2020

Front. Oncol.

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Background and Purpose: Although the prognostic value of lymphovascular invasion (LVI) for upper tract urinary carcinoma (UTUC) has been reported, there is a lack of consensus regarding the prognostic factor of LVI in UTUC after radical nephroureterectomy (RNU). The aim of the present study was to evaluate the contemporary role of LVI using systematic review and meta-analysis.Materials and Methods: Using Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, we performed a systematic search of Web of Science, PubMed, and EMBASE for all reports published up to July 2019. Cumulative analyses of hazard ratios (HRs)/odds ratios (ORs) and their corresponding 95% confidence intervals were conducted to assess the association between LVI and oncological outcomes and clinicopathological features.Results: Our meta-analysis included 31 eligible studies containing 14,653 patients with UTUC (81-1,363 per study). Our results indicated a significant correlation of LVI with worse cancer-specific survival (HR = 1.59, p < 0.001), overall survival (HR = 1.55, p < 0.001), recurrence-free survival (HR = 1.46, p < 0.001), cancer-specific mortality (HR = 1.25, p = 0.047), and recurrence (HR = 1.23, p = 0.026). LVI was also correlated with advanced tumor stage (III/IV vs. I/II: OR = 7.63, p < 0.001), higher tumor grade (3 vs. 1/2: OR = 5.61, p < 0.001), lymph node metastasis (yes vs. no: OR = 4.95, p < 0.001), carcinoma in situ (yes vs. no: OR = 1.92, p < 0.001), and positive surgical margin (yes vs. no: OR = 4.38, p < 0.001), but not related to gender (male vs. female: OR = 0.98, p = 0.825), and multifocality (multifocal vs. unifocal: OR = 1.09, p = 0.555). The funnel plot test indicated no significant publication bias.Conclusions: This study demonstrated that LVI was associated with aggressive clinicopathological features. LVI may serve as a poor prognostic factor for patients with UTUC after RNU.

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Section: Discussionmentioning

confidence: 99%

“…Lymphovascular invasion (LVI), which is defined as the presence of tumor cells within lymphatic or vascular channels, is a significant step in tumor distant metastasis (5,6). According to the recommended European urology guidelines, LVI is an independent prognostic factor for bladder cancer using cystectomy specimens (7).…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Value of Lymphovascular Invasion in Patients With Upper Tract Urinary Carcinoma After Surgery: An Updated Systematic Review and Meta-Analysis

Zhang

Zha

et al. 2020

Front. Oncol.

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“…Recently, mounting evidences have indicated that LVI is associated with poor prognosis for many kinds of tumors, such as liver, bladder, and prostate cancer [43,6]. Jiang et al [5] reported that LVI is an independent prognostic factor to predict worse progression in prostate cancer, and they recommended that LVI should be reported in the final pathological diagnosis after radical prostatectomy. Similarly, Canter et al [44] found that the presence of LVI in the final pathological reports for bladder cancer deliver significant risks for worse CSS and OS.…”

Section: Discussionmentioning

confidence: 99%

“…Lymphovascular invasion, which defined as the presence of tumor cells within lymphatic or vascular channels, is a significant and crucial step in tumor distant metastasis [4,5]. The prognostic value of LVI has been established for bladder cancer, and European guidelines recommend the description of LVI in cystectomy specimens as an independent prognostic factor [6].…”

Section: Introductionmentioning

confidence: 99%

The clinicopathological features and prognostic value of lymphovascular invasion in patients with upper tract urinary carcinoma after radical nephroureterectomy: an updated systematic review and meta-analysis.

Zhang

Zha

et al. 2019

Preprint

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Background and Purpose: Although the prognostic value of lymphovascular invasion (LVI) for upper tract urinary carcinoma (UTUC) have been described. There is lack of consensus regarding the prognostic factor of LVI in UTUC. The aim of present study was to evaluate the current evidence regarding the contemporary role of LVI through systematic review and meta-analysis according to the updated literatures. Materials and Methods: In the light of Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, a systematic search of Web of Science, PubMed and EMBASE was performed for all reports published until July 2019 that included detailed results on the predictors of LVI. Results: Our meta-analysis included thirty one eligible studies containing 14,653 UTUC patients (81-1,363 per study). According to our final results, there was a significant correlation of LVI with worse cancer-specific survival (CSS) (HR=1.62, 95 % CI: 1.49-1.76, p < 0.001), overall survival (OS) (HR=1.55, 95 % CI: 1.41-1.71, p < 0.001), recurrence-free survival (RFS) (HR=1.46, 95 % CI: 1.32-1.61, p < 0.001), cancer-specific mortality (CSM) (HR=1.25, 95 % CI: 1.00-1.56, p = 0.047) and recurrence(HR=1.23, 95 % CI: 1.03-1.48, p = 0.026). In addition, LVI was also correlated with advanced TNM stage (III/IV vs. I/II: OR = 7.63, 95% CI: 5.60–10.39, p < 0.001), higher tumor grade (3 vs. 1/2: OR = 5.61, 95% CI: 3.71–8.48, p < 0.001), lymph node metastasis (yes vs. no: OR = 4.95, 95% CI: 3.66–6.71, p < 0.001), carcinoma in situ (yes vs. no: OR = 1.92, 95% CI: 1.36–2.70, p < 0.001) and positive surgical margin (yes vs. no: OR = 4.38, 95% CI: 2.71–7.07, p < 0.001), but not related to gender (male vs. female: OR = 0.98, 95% CI: 0.80–1.19, p = 0.825) and multifocality (multifocal vs. unifocal: OR = 1.10, 95% CI: 0.82–1.47, p = 0.539). The funnel plot test indicated that no significant publication bias in the meta-analysis. Conclusions: This study demonstrated that LVI was associated with more aggressive clinicopathological features and could serve as a poor prognostic factor for patient with UTUC after radical nephroureterectomy.

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“…Although not all margin-positive patients experience BCR, the presence of a positive surgical margin is a well-established risk factor for BCR 29 . The presence of lymphovascular invasion is also considered as a potential risk factor for BCR 30 . However, after adjusting for all confounding factors, only the 'overweight' group showed significant correlation between lymphovascular invasion and BCR.…”

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Differences in risk factors for biochemical recurrence after radical prostatectomy stratified by the degree of obesity: Focused on surgical methods

Suh

Yoo

Park

et al. 2020

Sci Rep

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This study aims to evaluate differences in the risk factors for biochemical recurrence (BCR) for radical prostatectomy stratified by degree of obesity, focusing on the surgical method used. All 3099 patients who underwent radical prostatectomy in two medical centres from January 2008 to March 2018 were retrospectively reviewed. Patients were divided into three groups based on body mass index: 'normal', 'overweight', and 'obese'. Risk factors associated with biochemical recurrence were compared between different degrees of obesity. We analysed the contributing risk factors of BCRfree survival using univariate and multivariable Cox hazard models. There were 378 (12.2%) and 1815 (58.6%) patients in the 'obese' and 'overweight' groups, respectively. Accordingly, 1324 patients underwent retropubic radical prostatectomy (RRP), and 1775 underwent robotic-assisted laparoscopic prostatectomy (RALP). Multivariable analysis showed that patients who underwent RALP had significantly lower BCR free survival in the 'overweight' and 'obese' groups than those who underwent RRP, with adjusted hazard ratios of 0.75 (95% CI 0.59-0.95, p-value = 0.01) and 0.55 (95% CI 0.33-0.90, p-value = 0.02), respectively. The degree of obesity was not directly associated with BCR-free survival. Robotic prostatectomy showed greater benefits in BCR-free survival than open prostatectomy in the 'overweight' and 'obese' groups.

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The impact of lymphovascular invasion in patients with prostate cancer following radical prostatectomy and its association with their clinicopathological features

Abstract: Supplemental Digital Content is available in the text

Cited by 24 publications

References 41 publications

The Prognostic Value of Lymphovascular Invasion in Patients With Upper Tract Urinary Carcinoma After Surgery: An Updated Systematic Review and Meta-Analysis

The Prognostic Value of Lymphovascular Invasion in Patients With Upper Tract Urinary Carcinoma After Surgery: An Updated Systematic Review and Meta-Analysis

The clinicopathological features and prognostic value of lymphovascular invasion in patients with upper tract urinary carcinoma after radical nephroureterectomy: an updated systematic review and meta-analysis.

Differences in risk factors for biochemical recurrence after radical prostatectomy stratified by the degree of obesity: Focused on surgical methods

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