The impact of pesticides on oxidative stress level in human organism and their activity as an endocrine disruptor

Jabłońska-Trypuć, Agata; Wołejko, Elżbieta; Wydro, Urszula; Butarewicz, Andrzej

doi:10.1080/03601234.2017.1303322

Cited by 48 publications

(34 citation statements)

References 49 publications

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“…This alteration of dopaminergic pathways might contribute to Parkinson's disease, for which exposure to pesticides is suspected to be a risk factor . In the same way, the in vitro inhibition of steroid hormone transport by pesticides may theoretically participate in their in vivo endocrine disruptive effects, even if in vivo endocrine disruption by most pesticides remains rather incompletely documented to date.…”

Section: Modulation Of Drug Transporter Activity By Pesticidesmentioning

confidence: 99%

Implication of human drug transporters to toxicokinetics and toxicity of pesticides

Guéniche

Bruyère

Vée

et al. 2019

Pest Management Science

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Human membrane drug transporters are recognized as major actors of pharmacokinetics. Pesticides also interact with human drug transporters, which may have consequences for pesticide toxicokinetics and toxicity. The present review summarizes key findings about this topic. In vitro assays have demonstrated that some pesticides, belonging to various chemical classes, modulate drug transporter activity, regulate transporter expression and/or are substrates, thus bringing the proof of concept for pesticide‐transporter relationships. The expected low human concentration of pesticides in response to environmental exposure constitutes a key‐parameter to be kept in mind for judging the in vivo relevance of such pesticide‐transporter interactions and their consequences for human health. Existing data about interactions of pesticides with drug transporters remain, however, rather sparse; more extensive and systematic characterization of pesticide‐transporter relationships, through the use of high throughput in vitro assays and/or in silico methods, is, therefore, required. In addition, consideration of transporter polymorphisms, pesticide mixture effects and physiological and pathological factors governing drug transporter expression may help to better define the in vivo relevance of pesticide‐transporter interactions in terms of toxicokinetics and toxicity for humans. © 2019 Society of Chemical Industry

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Section: Modulation Of Drug Transporter Activity By Pesticidesmentioning

confidence: 99%

Implication of human drug transporters to toxicokinetics and toxicity of pesticides

Guéniche

Bruyère

Vée

et al. 2019

Pest Management Science

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“…OCPs disrupt human metabolism by increasing oxidative stress (OS) levels (9)(10)(11)(12). The loss of balance between the formation of reactive oxygen species (ROS) or nitrogen species (RNS) such as nitric oxide (NO) and the antioxidant defense mechanisms leads to a phenomenon called oxidative stress (OS) (6).…”

Section: Introductionmentioning

confidence: 99%

Association between Organochlorine Pesticides and Thyroid Tumors; an in-silico and in-vivo Case Control Study

Salimi

Asadikaram

Abolhassani

et al. 2020

Preprint

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Purpose: In this study, we aimed to investigate the role of organochlorine pesticides (OCPs), in the development of thyroid tumors. Method: Seven derived OCPs measured by gas chromatography (GC), and enzyme activities of acetylcholinesterase (AChE), superoxide dismutase3 (SOD3), catalase (CAT), glutathione peroxidase3 (GPx3) and paraoxonase1 (PON1) and also malondialdehyde (MDA), total antioxidant capacity (TAC), protein carbonyl (PC), and nitric oxide (NO), as oxidative stress (OS) biomarkers were assessed in the blood of 61 patients with papillary thyroid carcinoma (PTC), 70 patients with benign thyroid nodules (BTN), and 73 healthy individuals. Furthermore, all the studied enzymes were docked against the measured OCPs. Results: The results revealed that β-HCH, γ-HCH, 2,4 DDE, 4,4 DDE, 2,4-DDT, and 4,4-DDT levels along with MDA, NO and PC levels were elevated, while AChE, SOD3, GPx3, CAT, and PON1 activities and TAC levels were decreased in the PTC and BTN groups compared with the control group. Conclusion: The results of present study indicated that OCPs might play a major role in the development of thyroid tumors by disturbing the thyroid gland through several mechanisms including generation of OS. Importantly, in-silico analysis confirmed the in vivo findings.

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“…Recent studies have suggested oxidative stress as one of the mechanisms for the adverse health effects of pesticides exposure; the alteration of the physiological balance bring to the excess of oxidant species, resulting in severe damage to cellular components and macromolecules, especially the DNA [[17], [18], [19], [20], [21]]. Moreover, pesticides exposure may induce the modulation of cells functionality, especially that of the immune system (e.g.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms as determinants of pesticide toxicity: Recent advances

et al. 2019

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The impact of pesticides on oxidative stress level in human organism and their activity as an endocrine disruptor

Cited by 48 publications

References 49 publications

Implication of human drug transporters to toxicokinetics and toxicity of pesticides

Implication of human drug transporters to toxicokinetics and toxicity of pesticides

Association between Organochlorine Pesticides and Thyroid Tumors; an in-silico and in-vivo Case Control Study

Genetic polymorphisms as determinants of pesticide toxicity: Recent advances

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