The Impact of Urinary Urgency and Frequency on Health-Related Quality of Life in Overactive Bladder: Results from a National Community Survey

Coyne, Karin S.; Payne, Chris; Bhattacharyya, Samir; Revicki, Dennis A.; Thompson, Christine; Corey, R; Hunt, Timothy

doi:10.1111/j.1524-4733.2004.74008.x

Cited by 320 publications

(256 citation statements)

References 25 publications

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“…OAB greatly affects physical and social functioning, including work, sleep, and sexual relationships. 10,11 Because of symptom frequency, OAB patients usually decrease water intake and limit daily activity to avoid the discomfort. 12 There is some controversy about the classification and diagnosis of OAB.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of overactive bladder symptoms and urinary incontinence in a tertiary care hospital in Egypt

Bahloul

Abbas

Abo-Elhagag

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONThe overactive bladder (OAB) is a highly prevalent disorder that impacts the lives of millions of people worldwide. Despite its high prevalence, many sufferers do not seek medical attention and are not aware that OAB is treatable.1 Micturation disorders are responsible for increased morbidity throughout the world. This morbidity ranges from worrisome symptoms to life-threatening renal failure. Disturbances in voiding may sign neurological, metabolic, inflammatory, or infectious diseases. Voiding dysfunction may also arise from injury, outlet obstruction, structure changes in the bladder and urethra or loss of their supporting structures with aging. 2Research on urinary storage problems has focused on incontinence in women, but during last years, other urinary storage problems (urgency, frequency, and nocturia) has commanded attention worldwide.3 The prevalence of OAB is variable ranging from 3% to 43%, depending on the population assessed and the definition used. 4 The prevalence of OAB increase with age because of neurological and musculoskeletal effects, degenerative ABSTRACT Background: The current study aims to estimate the prevalence of Overactive bladder (OAB) and urinary incontinence (UI) among women attending Assiut Woman's Health Hospital. Additionally, to explore the impact of UI and OAB on The Quality of Life (QOL) of women. Methods: A population-based survey included participants aged 18 years and older selected from Assiut Woman's Health Hospital and received The Bristol Female Lower Urinary Tract Symptoms Questionnaire (BFLUTSQ). OAB was defined in to two versions using the international continence society (ICS) definition of 2002 as either urgency sometimes or more alone (OAB1) or urgency sometimes or more with frequency more than eight times per day and /or nocturia once or more per night (OAB2). Incontinence and other LUTS were positive if answer scores ≥2 to BFLUTSQ question for incontinence and other LUTS. Results: The total prevalence of OAB was 39.0% (351 women). The prevalence of OAB dry and OAB wet was 26% (234 women) and 13% (117 women), respectively, which suggested that 66.7% suffer from OAB dry and 33.3% suffer from OAB wet. The prevalence of dry OAB is significantly higher than wet OAB. The overall prevalence of UI was 22.2% (201 women). The prevalence of stress UI, urge UI and mixed UI was 5.7%, 5.1% and 11.4%, respectively. Conclusions: OAB symptoms and UI are highly prevalent. Furthermore, both of them have severe effects on daily and sexual life as well as being related to psychological symptoms such as anxiety and depression.

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Section: Introductionmentioning

confidence: 99%

Prevalence of overactive bladder symptoms and urinary incontinence in a tertiary care hospital in Egypt

Bahloul

Abbas

Abo-Elhagag

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…La OAB ha un impatto profondo sulla qualità di vita di chi ne è affetto, poiché interessa, compromettendole, le funzionalità fisica, psicologica, sessuale, sociale e lavorativa [2]. Mentre è intuitivo che una condizione di incontinenza vescicale, così come la frequenza e la nicturia, compromettano la qualità di vita, è stato rilevato che anche l'urgenza urinaria per sé ha un notevole impatto, che può giungere all'autoemarginazione sociale [3], oltre a rappresentare un fattore di rischio di frattura negli anziani che, per l'impellenza del bisogno e la fretta nel tentativo di "arrivare in tempo", possono incorrere in cadute accidentali.…”

Section: Introduzioneunclassified

Solifenacin in overactive bladder syndrome: pharmacoeconomic analysis

Iannazzo

Pradelli

2008

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The overactive bladder (OAB) syndrome can be treated with behavioural, surgical and/or pharmaceutical interventions, mainly represented by antimuscarinic drugs. Solifenacin is a new antimuscarinic with selectivity for the bladder and it demonstrated good effectiveness, safety and tolerability. Scope of the present study is to investigate the pharmacoeconomic performance of the treatment with solifenacin, when compared to tolterodine and placebo, in Italian patients with OAB. The economic evaluation is performed with a simulation model, based on a Markov chain. The time horizon of the simulation is 52 weeks, with a 1-week cycle. The model simulates the outcomes and costs of the treatment with solifenacin (5 mg/die), tolterodine ER (4 mg/die) and no treatment in a cohort representative of the Italian population with OAB (estimated in about 1,400 thousands patients). The cost analysis is conducted mainly in the perspective of the patient, since drugs for the treatment of OAB are currently not included in the Italian reimbursement list. The results show that both treatments produce significative improvements in symptoms and quality of life, with an increase in costs of about 540-640 Euro/year with solifenacin and of 680-780 Euro/year with tolterodine. In the cost-utility analysis, solifenacin dominates tolterodine since it results more effective and less costly, and its cost cost-utility ratio with respect to no treatment is in the range 7,600-18,600 Euro/QALY. In the subgroup of patients incontinent at baseline and who best respond to the therapy (responders), the increase in costs with solifenacin results of about 100-400 Euro/year and the cost-utility ratio is 600-4,200 Euro/QALY. A supplementary scenario has been elaborated to explore the consequences of a hypothetical reimbursement decision by the Italian NHS. In this scenario, the NHS cost perspective is considered and the antimuscarinic drugs are assumed to be reimbursed at a half of the current retail price only to incontinent and responder OAB patients. The overall expenditure of such a decision, which yields clear health outcomes, is estimated in about 23 millions Euro, with a cost-utility ratio of about 600-2,400 Euro/year, suggesting an efficient allocation of sanitary resources. Keywords: solifenacin, tolterodine, OAB, overactive bladder, Markov model Solifenacina nella terapia della sindrome da vescica iperattiva: valutazione farmacoeconomicaSergio Iannazzo (1) , Lorenzo Pradelli (1) Farmeconomia e percorsi terapeutici 2008; 9(1): 5-14 do lo sfintere uretrale intrinseco (costituito da muscolatura striata, sotto controllo volontario) finché non si ritiene giunto il momento adatto allo svuotamento, che viene iniziato mediante attivazione delle vie parasimpatiche (acetilcolinergiche) e contemporanea inibizione delle vie ortosimpatiche. Ne risultano rilassamento di sfinteri e piano pelvico e contrazione detrusoriale, mantenuta fino a svuotamento completato, cui segue la chiusura del collo vescicale, che completa il ciclo. La presenza di contrazi...

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“…Entonces, la prevalencia de vejiga hiperactiva no difiere entre ambos géneros, sin embargo, las diferencias anatómicas entre hombre y mujer, permiten que con el tiempo, se exprese con síntomas de urgencia miccional, con mayor frecuencia entre mujeres (3). Por otro lado, la vejiga hiperactiva, con o sin incontinencia de urgencia, posee un alto impacto en la calidad de vida, calidad de sueño y salud mental, para ambos géneros (4).…”

Section: Introductionunclassified

Neuromodulación Periférica en El Tratamiento De La Incontinencia De Orina: Efecto De La Estimulación Transcutánea Del Nervio Tibial Posterior Sobre La Vejiga Hiperactiva

et al. 2008

Rev. chil. obstet. ginecol.

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RESUMENObjetivo: Demostrar la efectividad de la neuromodulación con el sistema de estimulación transcutánea del nervio tibial posterior, en la inhibición de las contracciones no inhibidas del detrusor, en paciente con urgeincontinencia refractaria a tratamiento. Paciente: Se presenta un caso de incontinencia de orina mixta, con solución al componente de esfuerzo mediante TVT-Secur. El componente de urgencia, dado por vejiga hiperactiva, se trata mediante neuromodulación transcutánea del nervio tibial posterior, refractario al tratamiento medicamentoso y fisioterapia. Se demuestra objetivamente la acción de la neuromodulación, mediante la realización de una cistometría (urodinamia monocanal) durante la estimulación de nervio tibial (estímulos en modo continuo a 20 Hz y 200 milisegundos), comparada con la realizada sin estimulación. Resultados: Las contracciones no inhibidas del detrusor se inhibieron al realizar la neuromodulación con el sistema de estimulación transcutáneo del nervio tibial posterior, demostrado objetivamente por la desaparición de las contracciones durante la fase de llenado vesical. La capacidad cistométrica máxima, aumentó durante la neuromodulación y la sensación urgencia miccional disminuyó. Conclusión: La neuromodulación con el sistema de estimulación transcutánea del nervio tibial posterior, es efectiva en el tratamiento de la vejiga hiperactiva, lo que es posible de objetivar mediante la realización de una cistometría con urodinamia monocanal. Esta terapia ofrece una alternativa de tratamiento, con todas las características de mínima invasión.PALABRAS CLAVE: Incontinencia de orina, detrusor hiperactivo, vejiga hiperactiva, urge-incontinencia, urodinamia SUMMARYObjective: To demonstrate objectively the efficiency of the neuromodulation with the transcuteneous posterior tibial nerve stimulation in overactive bladder, in a patient with urge incontinence, refractory to traditional treatments. Patient: A case of urinary mixed incontinence is presented. The TVT-Secur was used for the stress urinary incontinence. The urge-incontinence due to overactive bladder was treated by transcutaneous tibial nerve neuromodulation when refractory appearing to the treatment with medicines and physiotherapy by thirty days. The action of the neuromodulation is demonstrated objectively by cystometry. Monochannel urodynamic equipment was used. The Biomed 2000 equipment was used for the transcutaneous neuromodulation, with stimuli in continuos way to 20 Hertz and 200 milliseconds. Results: The transcutaneous tibial 209 REV CHIL OBSTET GINECOL 2008; 73(3): 209 -213

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The Impact of Urinary Urgency and Frequency on Health-Related Quality of Life in Overactive Bladder: Results from a National Community Survey

Abstract: The experience of urinary urgency has a significant negative effect on HRQL and increases symptom bother, an effect that, in this community sample, is greater than that of incontinence, frequency, or nocturia.

Cited by 320 publications

References 25 publications

Prevalence of overactive bladder symptoms and urinary incontinence in a tertiary care hospital in Egypt

Prevalence of overactive bladder symptoms and urinary incontinence in a tertiary care hospital in Egypt

Solifenacin in overactive bladder syndrome: pharmacoeconomic analysis

Neuromodulación Periférica en El Tratamiento De La Incontinencia De Orina: Efecto De La Estimulación Transcutánea Del Nervio Tibial Posterior Sobre La Vejiga Hiperactiva

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