The impact of vitamin D deficiency on behaviour and brain function in rodents

Overeem, Kathie; Eyles, Darryl W.; McGrath, John J.

doi:10.1016/j.cobeha.2015.11.012

Cited by 5 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin D modulates different processes, such as neurogenesis, cell proliferation, differentiation, and neurotransmitter metabolism (Eyles et al, 2013 , 2014 ; Cui et al, 2015 ). By exposing fetal animals to vitamin D deficiency, an evident alteration of dopamine and NMDA circuitries can be observed, with clear consequences for altered behavior, memory and motor assessment (Becker et al, 2005 ; Turner et al, 2013 ; Eyles et al, 2014 ; Cui et al, 2015 ; Overeem et al, 2016 ). On the other hand, the exposition of previously normally developed brains to vitamin D deficiency seems to result in memory impairment, with major conduct alterations and with less executive possibilities (Byrne et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D, Homocysteine, and Folate in Subcortical Vascular Dementia and Alzheimer Dementia

Moretti

Caruso

Ben

et al. 2017

Front. Aging Neurosci.

View full text Add to dashboard Cite

Dementia is a worldwide health problem which affects millions of patients; Alzheimer's disease (AD) and subcortical vascular dementia (sVAD) are the two most frequent forms of its presentation. As no definite therapeutic options have been discovered, different risk factors for cognitive impairment have been searched for potential therapies. This report focuses on the possible evidence that vitamin D deficiency and hyper-homocysteinemia can be considered as two important factors for the development or the progression of neurodegenerative or vascular pathologies. To this end, we assessed: the difference in vascular risk factors and vitamin D-OH25 levels among groups of sVAD, AD, and healthy age-matched controls; the association of folate, B12, homocysteine, and vitamin D with sVAD/AD and whether a deficiency of vitamin D and an increment in homocysteine levels may be related to neurodegenerative or vessel damages. The commonly-considered vascular risk factors were collected in 543 patients and compared with those obtained from a healthy old volunteer population. ANOVA group comparison showed that vitamin D deficiency was present in demented cases, as well as low levels of folate and high levels of homocysteine, more pronounced in sVAD cases. The statistical models we employed, with regression models built, and adjustments for biochemical, demographic and neuropsychiatric scores, confirmed the association between the three measures (folate decrease, hyperhomocysteinemia and vitamin D decrease) and dementia, more pronounced in sVAD than in AD.

show abstract

Section: Discussionmentioning

confidence: 99%

Vitamin D, Homocysteine, and Folate in Subcortical Vascular Dementia and Alzheimer Dementia

Moretti

Caruso

Ben

et al. 2017

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…The knock-out model of VDR-/-has an accelerated aging process in all the organs, and in the brain [17][18], with a significant in-brain decrease of NGF [19] and of other neurotransmitters, such as acetylcholine [20][21][22][23][24]. Congenital deficiency of vitamin D significantly reduces the activity of glutamic acid decarboxylase (GAD) 65/67 (key enzymes in GABAergic inter-neurons) and the levels of glutamate and glutamine in brain tissue [25].…”

Section: Methabolism and Biological Actions Of Vitamin Dmentioning

confidence: 99%

“…One study investigated cognitive effects of IU/day may be started when the deficiency has been corrected, and at once in case of vitamin D insufficiency (20)(21)(22)(23)(24)(25)(26)(27)(28)(29) ng/mL). Since current evidence also suggests both obstetric and pediatric benefit from vitamin D against the risk of developing MS, vitamin D supplementation in children and pregnant women at risk of developing or being affected by MS should be considered [144].…”

mentioning

confidence: 99%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

View full text Add to dashboard Cite

It is widely known that vitamin D receptors have been found in neurons and glial cells and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. The vitamin D helps the regulation of neurotrophin, neural differentiation and maturation, through the control operation of growing factors synthesis (ie NGF and GDNF), the trafficking of the septo-hyppocampal pathway, and the control of the synthesis process of different neuromodulators (such as Ach, DA, and GABA).Based on these assumptions, we have written this review in order to summarize the potential role of vitamin D in neurological pathologies. The work could be titanic, and might result very fuzzy and even incoherent, if we would not have conjectured to taper our first intentions and devoted our interests towards three mainstreams: demyelinating pathologies, vascular syndromes and neurodegeneration.Due to the lack of effective therapeutic options, a part from the disease modifying strategies, the role of different risk factors should be investigated in neurology, as far as their correction may lead to the improvement of the cerebral conditions.We have explored the relationships between the gene-environmental influence and long term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation. Peer-reviewed version available at Int. J. Mol. Sci. 2018, 19, 2245 doi:10.3390/ijms19082245 3 SEARCH STRATEGY AND SELECTION CRITERIAWe searched MEDLINE using the search terms: "vitamin D central nervous system" , both "vitamin D" and "central nervous system"; "vitamin D immune system/response", both "vitamin D" and "immune system" or "immune response"; "vitamin D multiple sclerosis risk", both "vitamin D" and "multiple sclerosis risk"; "vitamin D multiple sclerosis relapse", both "vitamin D" and "multiple sclerosis relapse"; "vitamin D multiple sclerosis magnetic resonance imaging", both "vitamin D" and "multiple sclerosis magnetic resonance imaging"; "vitamin D multiple sclerosis disability", both "vitamin D" and "multiple sclerosis disability"; "vitamin D supplementation/therapy/treatment multiple sclerosis", both "vitamin D supplementation" or "vitamin D therapy" or "vitamin D treatment" and "multiple sclerosis"; "vascular dementia", both as -vascular-and -dementia-, "subcortical vascular dementia", both assubcortical-and -dementia-, "Alzheimer's disease", "pathogenesis neurodegeneration" "amyloid", "cholinergic afferents", "arteriolosclerosis", "cerebral flow regulation", "stroke". Publications were selected mostly form the past 20years, but did not exclude frequently referenced and highly regarded older publications. . Congress abstracts and isolated case reports were not considered. We searched the reference lists of articles identified by this search strategy and selected those we judged relevant. Review articles and book chapters are cited to provide with ...

show abstract

“…For example, brain structural abnormalities include an enlarged brain at birth, increased lateral ventricle volumes, increased overall cell proliferation and altered neurotransmission [61,68]. In behavioural domains the most replicated finding is hyperlocomotion, increased sensitivity to N-methyl-Daspartate (NMDA) antagonists and reduced cognitive functions [61,69,70].…”

Section: Animal Models Of Vitamin D Deficiency and The Developing Brainmentioning

confidence: 99%

Developmental vitamin D deficiency and autism: Putative pathogenic mechanisms

Ali

Cui

Eyles

2018

The Journal of Steroid Biochemistry and Molecular Biology

View full text Add to dashboard Cite

Autism is a neurodevelopmental disease that presents in early life. Despite a considerable amount of studies, the neurobiological mechanisms underlying autism remain obscure. Both genetic and environmental factors are involved in the development of autism. Vitamin D deficiency is emerging as a consistently reported risk factor in children. One reason for the prominence now being given to this risk factor is that it would appear to interact with several other epidemiological risk factors for autism. Vitamin D is an active neurosteroid and plays crucial neuroprotective roles in the developing brain. It has important roles in cell proliferation and differentiation, immunomodulation, regulation of neurotransmission and steroidogenesis. Animal studies have suggested that transient prenatal vitamin D deficiency is associated with altered brain development. Here we review the potential neurobiological mechanisms linking prenatal vitamin D deficiency and autism and also discuss what future research targets must now be addressed.

show abstract

The impact of vitamin D deficiency on behaviour and brain function in rodents

Cited by 5 publications

References 45 publications

Vitamin D, Homocysteine, and Folate in Subcortical Vascular Dementia and Alzheimer Dementia

Vitamin D, Homocysteine, and Folate in Subcortical Vascular Dementia and Alzheimer Dementia

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Developmental vitamin D deficiency and autism: Putative pathogenic mechanisms

Contact Info

Product

Resources

About