The Importance of Antibacterial Surfaces in Biomedical Applications

Benčina, Metka; Mavrič, Tina; Junkar, Ita; Bajt, Aleksander; Krajnović, Aleksandra; Lakota, Katja; Žigon, Polona; Sodin‐Šemrl, Snežna; Kralj‐Iglič, Veronika; Iglič, Aleš

doi:10.1016/bs.abl.2018.05.001

Cited by 35 publications

(19 citation statements)

References 200 publications

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“…In particular, this electrical antibacterial effect has barely been studied in polymeric biomaterials, which presents an opportunity to complement several strategies developed to eradicate bacterial growth motivated by the increase in antibiotic resistance and the high cost of treating bacterial infections [17]. For example, osteomyelitis and other bacterial diseases associated with bone prostheses can bring serious consequences to patients, such as the removal of bone implants, lengthening the wound healing processes, and increasing the cost associated with surgery [17][18][19][20][21][22]. Therefore, several materials and methods have been developed to eradicate bacteria colonies from biomaterial surfaces before the formation of a biofilm, since it is harder to eliminate the consortium of bacterial colonies afterward [18].…”

Section: Introductionmentioning

confidence: 99%

Electroactive 3D Printed Scaffolds Based on Percolated Composites of Polycaprolactone with Thermally Reduced Graphene Oxide for Antibacterial and Tissue Engineering Applications

et al. 2020

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Applying electrical stimulation (ES) could affect different cellular mechanisms, thereby producing a bactericidal effect and an increase in human cell viability. Despite its relevance, this bioelectric effect has been barely reported in percolated conductive biopolymers. In this context, electroactive polycaprolactone (PCL) scaffolds with conductive Thermally Reduced Graphene Oxide (TrGO) nanoparticles were obtained by a 3D printing method. Under direct current (DC) along the percolated scaffolds, a strong antibacterial effect was observed, which completely eradicated S. aureus on the surface of scaffolds. Notably, the same ES regime also produced a four-fold increase in the viability of human mesenchymal stem cells attached to the 3D conductive PCL/TrGO scaffold compared with the pure PCL scaffold. These results have widened the design of novel electroactive composite polymers that could both eliminate the bacteria adhered to the scaffold and increase human cell viability, which have great potential in tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Electroactive 3D Printed Scaffolds Based on Percolated Composites of Polycaprolactone with Thermally Reduced Graphene Oxide for Antibacterial and Tissue Engineering Applications

et al. 2020

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“…In biomedical applications, bacterial infections can cause tissue destruction, premature device failure, and the spread of infection to other areas [143,144]. For instance, bone implants are always associated with risks of bacterial infection that leads to implant failure or, in critical cases, amputation or death of the patient [144,145]. In contact with the eye lens this process causes serious eye infections [146].…”

Section: Antimicrobial and Antifouling Polymers Based On Electricamentioning

confidence: 99%

“…In contact with the eye lens this process causes serious eye infections [146]. Other examples of fouling formation are in catheter-associated urinary tract infections [147,148], and dental implants cause periodontal diseases and gingivitis [144]. Therefore, it is of great importance to eradicate biofilm formation avoiding the reversible anchoring of bacterial colonies [149].…”

Section: Antimicrobial and Antifouling Polymers Based On Electricamentioning

confidence: 99%

Electroactive Smart Polymers for Biomedical Applications

2019

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The flexibility in polymer properties has allowed the development of a broad range of materials with electroactivity, such as intrinsically conductive conjugated polymers, percolated conductive composites, and ionic conductive hydrogels. These smart electroactive polymers can be designed to respond rationally under an electric stimulus, triggering outstanding properties suitable for biomedical applications. This review presents a general overview of the potential applications of these electroactive smart polymers in the field of tissue engineering and biomaterials. In particular, details about the ability of these electroactive polymers to: (1) stimulate cells in the context of tissue engineering by providing electrical current; (2) mimic muscles by converting electric energy into mechanical energy through an electromechanical response; (3) deliver drugs by changing their internal configuration under an electrical stimulus; and (4) have antimicrobial behavior due to the conduction of electricity, are discussed.

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“…The prolonged antimicrobial therapy can result in revision surgery and implant removal, which can be life threatening for patients. Thus it is highly important to develop biomaterial surfaces which would prevent bacterial invasion [ 9 ]. There are two major factors causing implant failure: (i) infection and (ii) aseptic loosening [ 10 ].…”

Section: The Use Of Ss In the Biomedical Fieldmentioning

confidence: 99%

“…Although antibiotic resistance evolves naturally via mutation, new resistance mechanisms are emerging and spreading globally, mainly due to the misuse and/or overuse of antibiotics, as well as improper infection prevention [ 9 ]. Antibiotic-resistant bacteria are considered as an emergent global disease and present a major public health care problem [ 29 ].…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Strategies for Improving Antimicrobial Properties of Stainless Steel

et al. 2020

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In this review, strategies for improving the antimicrobial properties of stainless steel (SS) are presented. The main focus given is to present current strategies for surface modification of SS, which alter surface characteristics in terms of surface chemistry, topography and wettability/surface charge, without influencing the bulk attributes of the material. As SS exhibits excellent mechanical properties and satisfactory biocompatibility, it is one of the most frequently used materials in medical applications. It is widely used as a material for fabricating orthopedic prosthesis, cardiovascular stents/valves and recently also for three dimensional (3D) printing of custom made implants. Despite its good mechanical properties, SS lacks desired biofunctionality, which makes it prone to bacterial adhesion and biofilm formation. Due to increased resistance of bacteria to antibiotics, it is imperative to achieve antibacterial properties of implants. Thus, many different approaches were proposed and are discussed herein. Emphasis is given on novel approaches based on treatment with highly reactive plasma, which may alter SS topography, chemistry and wettability under appropriate treatment conditions. This review aims to present and critically discuss different approaches and propose novel possibilities for surface modification of SS by using highly reactive gaseous plasma in order to obtain a desired biological response.

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The Importance of Antibacterial Surfaces in Biomedical Applications

Cited by 35 publications

References 200 publications

Electroactive 3D Printed Scaffolds Based on Percolated Composites of Polycaprolactone with Thermally Reduced Graphene Oxide for Antibacterial and Tissue Engineering Applications

Electroactive 3D Printed Scaffolds Based on Percolated Composites of Polycaprolactone with Thermally Reduced Graphene Oxide for Antibacterial and Tissue Engineering Applications

Electroactive Smart Polymers for Biomedical Applications

Strategies for Improving Antimicrobial Properties of Stainless Steel

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