The importance of CD39, CD43, CD81, and CD95 expression for differentiating B cell lymphoma by flow cytometry

Abstract

In combination, CD39, CD43, CD81, and CD95 expressions appear to be helpful to distinguish CD10 BCL, particularly BL. Phenotypic distinction between FL and GCB DLBCL remains challenging and requires further studies. © 2017 International Clinical Cytometry Society.

From the Editor: Thank you! Remembrances and Issue Highlights

“…The initial contribution by Seegmiller, His and Craig [(3) & cover article] is a review of flow cytometry in the evaluation of mature B-cell neoplasms, a topic of regular interest to our readership as evidenced by these recent publications (3)(4)(5)(6)(7)(8). This is a joint effort of the ICCS and our Society's own Sa Wang and the Society of Hematopathology, represented by Magdalena Czader.…”

“…Wang and Czader are the Guest Editors of this series that will ultimately be collated and published by John Wiley as an open-access electronic book. The initial contribution by Seegmiller, His and Craig [(3) & cover article] is a review of flow cytometry in the evaluation of mature B-cell neoplasms, a topic of regular interest to our readership as evidenced by these recent publications (3)(4)(5)(6)(7)(8). The review by Drs.…”

Issue Highlights—May 2018 (94B3)

“…Chandra Cardoso et al from University Hospital of the Federal University of Santa Catarina in Florianopolis Brazil report on the expression of CD39, CD43, CD81, and CD95 on CD10+ B cell lymphomas in their manuscript entitled “ The Importance of CD39, CD43, CD81 and CD95 Expression for Differentiating B Cell Lymphoma by Flow Cytometry .” The study includes 27 patients. Eleven patients were diagnosed with diffuse large B cell lymphoma, nine with follicular lymphoma, and seven with Burkitt's Lymphoma.…”

Evaluation of CD307a expression patterns during normal B‐cell maturation and in B‐cell malignancies by flow cytometry

“…Currently, diagnosis of B-cell malignancies is based on WHO criteria, which combine immunophenotypic, morphological, clinical, molecular, and cytogenetic information for the correct subclassification of these disorders. In such cases, the investigation of novel immunophenotypic markers, which has been the subject of previous studies (5)(6)(7), takes on importance, as it might provide more precise panels to improve the diagnostic accuracy of B-cell lymphomas by flow cytometry. Histopathological analysis is necessary in such instances, as it provides key diagnostic information.…”

“…Additional investigations may be unfeasible due to economic limitations or the absence of accessible pathological tissue. In such cases, the investigation of novel immunophenotypic markers, which has been the subject of previous studies (5)(6)(7), takes on importance, as it might provide more precise panels to improve the diagnostic accuracy of B-cell lymphomas by flow cytometry.…”