2019
DOI: 10.1097/mou.0000000000000625
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The importance of developing relevant animal models to assess existing and new materials

Abstract: Purpose of reviewWe summarize the recent literature on the use of different animal models for testing existing and new materials for treatment of pelvic organ prolapse. Recent findingsA wide spectrum of animal models is being used in urogynecology, both for the study of physiologic and pathophysiologic processes, training in surgical procedures, yet mainly to study the host response to implant materials. The quality of studies is variable, and procedures, read-outs, and reporting are not standardized. This mak… Show more

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Cited by 2 publications
(5 citation statements)
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“…Meta‐analysis could only include 11% of the outcomes due to the infrequent and qualitative nature of outcome reporting. We, therefore, conclude that animal studies on host response after vaginal mesh surgery are highly heterogeneous, confirming previous observations in narrative reviews 16,17 …”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…Meta‐analysis could only include 11% of the outcomes due to the infrequent and qualitative nature of outcome reporting. We, therefore, conclude that animal studies on host response after vaginal mesh surgery are highly heterogeneous, confirming previous observations in narrative reviews 16,17 …”
Section: Discussionsupporting
confidence: 89%
“…We, therefore, conclude that animal studies on host response after vaginal mesh surgery are highly heterogeneous, confirming previous observations in narrative reviews. 16 , 17 …”
Section: Discussionmentioning
confidence: 99%
“…Rats 32 40 were used; however, due to its small body size studies at vaginal level are very difficult to be performed. The same for mice 18 , where most studied materials are implanted subcutaneously, rather than vaginally 41 43 .…”
Section: Discussionmentioning
confidence: 99%
“…Published studies show that several models can be used, and there is no animal that is perfect for this purpose. Each one has its own benefits and weakness 16 18 .…”
Section: Introductionmentioning
confidence: 99%
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