2022
DOI: 10.1371/journal.pone.0277363
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The in silico and in vitro analysis of donepezil derivatives for Anopheles acetylcholinesterase inhibition

Abstract: Current studies on Anopheles anticholinesterase insecticides are focusing on identifying agents with high selectivity towards Anopheles over mammalian targets. Acetylcholinesterase (AChE) from electric eel is often used as the bioequivalent enzyme to study ligands designed for activity and inhibition in human. In this study, previously identified derivatives of a potent AChE, donepezil, that have exhibited low activity on electric eel AChE were assessed for potential AChE-based larvicidal effects on four Afric… Show more

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Cited by 2 publications
(1 citation statement)
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“…It is due to the limited regenerative capacity of the adult nervous system and the death or irreversible dysfunction of the neural cells (Achilleos & Trainor, 2012; Fauser et al, 2021; Matsubara et al, 2021). Currently, the drugs approved by the Food and Drug Administration (FDA) such as MDA receptor antagonists, levodopa, and donepezil are used to prolong neurodegeneration by supplementing neurotransmitters and neurotrophic factors (Gao et al, 2022; Honorio et al, 2022; Nagai et al, 2022; Osmaniye et al, 2023; Rants'o et al, 2022; Safarpour et al, 2022). Unfortunately, the adverse effects of these drugs have gradually been revealed (Audira et al, 2020; Hagiwara‐Nagasawa et al, 2021; Kurihara et al, 2022; Morris et al, 2021; Rus et al, 2022; Wang, Zong, et al, 2022).…”
Section: Introductionmentioning
confidence: 99%
“…It is due to the limited regenerative capacity of the adult nervous system and the death or irreversible dysfunction of the neural cells (Achilleos & Trainor, 2012; Fauser et al, 2021; Matsubara et al, 2021). Currently, the drugs approved by the Food and Drug Administration (FDA) such as MDA receptor antagonists, levodopa, and donepezil are used to prolong neurodegeneration by supplementing neurotransmitters and neurotrophic factors (Gao et al, 2022; Honorio et al, 2022; Nagai et al, 2022; Osmaniye et al, 2023; Rants'o et al, 2022; Safarpour et al, 2022). Unfortunately, the adverse effects of these drugs have gradually been revealed (Audira et al, 2020; Hagiwara‐Nagasawa et al, 2021; Kurihara et al, 2022; Morris et al, 2021; Rus et al, 2022; Wang, Zong, et al, 2022).…”
Section: Introductionmentioning
confidence: 99%